A neglected disease. Human sporotrichosis in a densely populated urban area in São Paulo, Brazil: clinical–epidemiological and therapeutic aspects

Bittencourt, Amanda Azevedo; Oyafuso, Luiza Keiko; Cavalin, Roberta Figueiredo; Palhares, Renata Bacic; Benard, Gil; Gimenes, Viviane Mazo Fávero; Negro, Gilda Maria Bárbaro Del; Siqueira, Lumena Pereira Machado; Xavier, Roseli Santos de Freitas; Lópes-Bezerra, Leila M.; Buccheri, Renata; Lindoso, José Ângelo Lauletta

doi:10.1007/s42770-022-00713-5

Cited by 8 publications

(17 citation statements)

References 38 publications

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“…This study evaluated 255 cases of human sporotrichosis admitted to the Infectious Diseases reference hospital of São Paulo city. As described earlier for the epidemic that arose in Rio de Janeiro, Brazil, 25 years ago, the transmission route was exclusively zoonotic, through exposure to infected cats 6,9,27 . Similar to previously reported in this state, 34.35 middle‐aged women were predominantly affected, likely due to the highest incidence occurring among caregivers of sick animals, a role usually assumed by women 27 .…”

Section: Discussionsupporting

confidence: 78%

“…However, in 2015 the number of human cases sharply raised: from three cases in 2014 to 14 cases in 2015, which then escalated in 2016. We previously described this outbreak's clinical and epidemiological data 27 …”

Section: Discussionmentioning

confidence: 99%

“…All patients had cutaneous lesions specimens collected by biopsy for laboratory diagnosis by direct microscopy and fungus culture. Most parts of the patients included in the present were the subject of a prior publication on clinical, demographic, and therapeutic features of the São Paulo outbreak of sporotrichosis 27 . Sporothrix ssp.…”

Section: Methodsmentioning

confidence: 99%

“…Most parts of the patients included in the present were the subject of a prior publication on clinical, demographic, and therapeutic features of the São Paulo outbreak of sporotrichosis. 27 Sporothrix ssp. was identified based on its morphological characteristics through direct microscopic examination (DME) and culture.…”

Section: Introductionmentioning

confidence: 99%

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Seasonality of sporotrichosis in Brazil: A modelled analysis of the epidemic in São Paulo, 2011–2020

de Freitas,

Rocha,

Ribeiro

et al. 2023

Mycoses

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Background: Sporotrichosis is an endemic subcutaneous mycosis classically caused by the Sporothrix schenckii species complex. Recently, sporotrichosis has emerged in Brazil as a cat-transmitted epidemic caused by a new species, Sporothrix brasiliensis. Objectives: To survey the clinical-epidemiological profile of all sporotrichosis cases diagnosed between 2011 and 2020 at a reference hospital in São Paulo metropolitan area and evaluate the annual distribution of cases in relation to seasonality. Methods: Patients' demographic and clinical-epidemiological data were surveyed. A generalized linear model was fitted to relate the quarterly number of sporotrichosis cases detected between 2015 and 2019 with precipitation and temperature series. Prediction of the number of cases from 2011 to 2014 was attempted based on the fitted model without the trend component that appears from 2015.Results: Among 271 suspected cases admitted during 2011-2020, 254 were confirmed by fungal isolation and/or clinical-epidemiological criteria. We observed that 2015 onwards the number of cases regularly increased during Autumn and Winter, the driest and coldest stations of the year. We verified that temperature series affected the number of cases (p = .005) because an increase of 1°C in the temperature series was associated with a 14.24% decrease in the average cases number, with the average number of cases increasing by 10.96% (p < .0001) every quarter, corresponding to an annual increase of 52%. Between 2011 and 2014, the predicted number of sporotrichosis cases averaged 10-12 per year, with 33%-38% occurring in the winter. Conclusion:We hypothesize that sporotrichosis seasonality is associated with the felines' oestrus cycle, which may provide alternative, cat-directed approaches to the sporotrichosis epidemic control.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Seasonality of sporotrichosis in Brazil: A modelled analysis of the epidemic in São Paulo, 2011–2020

de Freitas,

Rocha,

Ribeiro

et al. 2023

Mycoses

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“…Lymphocutaneous (LC) ‒ It is the most common clinical form, accounting for 46% to 92% of cases. 36 Clinically, it starts with the appearance, days to a few months after the trauma, of a small erythematous papule or pustule at the site of fungus inoculation. It is also called sporotichotic or inoculation chancre and usually is asymptomatic, tends to increase in size in a few weeks, and becomes nodular.…”

Section: Resultsmentioning

confidence: 99%

Human sporotrichosis: recommendations from the Brazilian Society of Dermatology for the clinical, diagnostic and therapeutic management

Orofino-Costa

Freitas²,

Bernardes-Engemann

et al. 2022

Anais Brasileiros de Dermatologia

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Emerging Cases of Cat-Transmitted Sporotrichosis Driven by Sporothrix brasiliensis in Northeast Brazil

de Oliveira,

de Carvalho,

Costa

et al. 2024

Mycopathologia

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A neglected disease. Human sporotrichosis in a densely populated urban area in São Paulo, Brazil: clinical–epidemiological and therapeutic aspects

Cited by 8 publications

References 38 publications

Seasonality of sporotrichosis in Brazil: A modelled analysis of the epidemic in São Paulo, 2011–2020

Seasonality of sporotrichosis in Brazil: A modelled analysis of the epidemic in São Paulo, 2011–2020

Human sporotrichosis: recommendations from the Brazilian Society of Dermatology for the clinical, diagnostic and therapeutic management

Emerging Cases of Cat-Transmitted Sporotrichosis Driven by Sporothrix brasiliensis in Northeast Brazil

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