A negatively-charged region within carboxy-terminal domain maintains proper CTCF DNA binding
Lian Liu,
Yuanxiao Tang,
Qiang Wu
Abstract:SUMMARYAs an essential regulator of higher-order chromatin structures, CTCF is a highly-conserved DNA binding protein with a central DNA-binding domain of 11 tandem zinc fingers, which are flanked by N- and C-terminal domains of intrinsically disordered regions. The N-terminal domain interacts with cohesin complex and the central zinc finger domains recognize a large range of diverse genomic sites. However, the function of unstructured C-terminal domain remains unknown. Here we report that CRISPR deletion of t… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.