Abstract:The mutant hKv1.3_V388C channel shows inward current at potentials more negative than 100 mV when the central apore is closed (Pruetting et al., JBC 286:20031-20042). We believe that the V388C mutation in hKv1.3 channels opens a new pathway (s-pore) behind the K þ conducting apore. The entry of the spore from the extracellular side is presumably located at the backside of Y395 (Shaker position 445) and F384 (Shaker position 434). One spore seems to be formed between two neighboring S6 subunits and it runs par… Show more
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