A near infrared singlet oxygen probe and its applications in in vivo imaging and measurement of singlet oxygen quenching activity of flavonoids

Liang, Dong; Zhang, Yuannian; Wu, Zhiyuan; Chen, Yong Jun; Yang, Xin; Sun, Mingtai; Ni, Runyan; Bian, Jin-Song; Huang, Dejian

doi:10.1016/j.snb.2018.03.024

Cited by 25 publications

(14 citation statements)

References 32 publications

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“…In our previous works on silica-coated fluorescent polystyrene microspheres and silica-coated nanoparticles of Cd compounds, the fluorescence of both silica-coated particles diminished more slowly than that of the particles before the silica coating [31][32][33]. Oxygen molecules in the singlet state, that is, at the exited stage, decompose dye molecules [39,40]. QDs suffer from oxidation that takes place at their surface under exposure to oxygen molecules in air, solvent, and light [13][14][15][16][17], which decreases the fluorescence intensity of QDs.…”

Section: Fluorescence Propertiesmentioning

confidence: 93%

Silica coating of indium phosphide nanoparticles by a sol–gel method and their photobleaching properties

et al. 2019

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Indium phosphide (InP) nanoparticles face at problems such as aggregation and photobleaching, and formation of core-shell structure is promising to solve the problems. This paper examined the method of coating the InP nanoparticles with silica via sol-gel reaction in reverse micelles. Fabrication of silica-coated InP (InP/SiO 2) nanoparticles was performed by using the reverse microemulsion method, in which the sol-gel reaction of tetraethyl orthosilicate and water with ammonia is performed in reverse micelles composed of polyoxyethylene (5) nonylphenylether, branched in cyclohexane containing InP nanoparticles. The InP nanoparticles did not aggregate because of physical barriers of silica shells. The silica coating controlled photobleaching of the InP nanoparticles; the colloid solution of InP/SiO 2 nanoparticles emitted more stable fluorescence than that of the shell-free InP nanoparticles, even after the InP/SiO 2 nanoparticles were placed in a dark box in an atmosphere set to room temperature.

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Section: Fluorescence Propertiesmentioning

confidence: 93%

Silica coating of indium phosphide nanoparticles by a sol–gel method and their photobleaching properties

et al. 2019

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“…The probe produced a peroxy bond (OO) by the oxidation reaction with 1 O 2 ( Figure ), resulting in a fluorescence enhancement with good selectivity over other ROS. Following on from this, an anthracene‐fused probe was developed for the detection of 1 O 2 . The probe showed an enhanced fluorescence intensity through the formation of a peroxy‐bond by 1 O 2 in acetonitrile.…”

Section: Fluorescent Probes For the Detection Of Ros‐related Diseasesmentioning

confidence: 99%

“…The probe targeted mitochondria in cells, but not at a high dosage. Moreover, Huang and co‐workers reported a probe which could form a peroxy bond with 1 O 2 , inducing a fluorescence change. The probe was used for the imaging of 1 O 2 in vivo in mice with the help of PDT agent rose Bengal and light irradiation ( Figure ).…”

Section: Fluorescent Imaging Agents For Diagnosis Of Ros‐relevant Dismentioning

confidence: 99%

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Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

et al. 2019

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Reactive oxygen species (ROS) consist of a diverse range of oxidative small molecular ions and free radicals that are produced throughout the body during certain biological processes. Due to their high reactivity, these molecules result in the damage of tissues and cells. Therefore, ROS have been implicated in an array of diseases including cancer, inflammation, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Owing to the simplicity, sensitivity, and selectivity of fluorescence‐based strategies, many small‐molecular sensors or imaging agents have been developed to sense and visualize ROS both in vitro and in vivo. Likewise, activatable drug delivery and prodrug systems that can be triggered by ROS for disease theranostics (diagnostic and therapeutic combined) have been developed. Herein, recently developed fluorescence‐based sensing and imaging agents for the detection of ROS both intracellularly and in vivo are summarized. In addition, drug delivery, which require activation by ROS to achieve disease theranostics is also discussed.

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“…As mediators of oxidative stress, reactive oxygen species (ROS), including superoxide radical anion (O 2 •− ), hydroxyl radical (·OH), singlet oxygen ( 1 O 2 ) and hydrogen peroxide, have been regarded as the main reason leading to many diseases [1]. As the first excited state 1 Δ g of molecular oxygen, 1 O 2 is considered as one of the most active classes involved in chemical and biochemical reactions, since it can easily react with a large number of biological molecules, such as DNA, proteins and lipids [2]. 1 O 2 mediated DNA damage can lead to neurological disorders like Alzheimer’s and Parkinson’s disease, and even increased risk of cancer [3].…”

Section: Introductionmentioning

confidence: 99%

Carbon-Carbon Double Bond and Resorcinol in Resveratrol and Its Analogues: What Is the Characteristic Structure in Quenching Singlet Oxygen?

et al. 2019

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Stilbenes, particularly resveratrol and resveratrol dimers, could effectively quench singlet oxygen (1O2). It was reported that both resorcinol and carbon-carbon double bond quenching 1O2 can participate in the mechanism. However, it is still not clear which structure plays a dominant role in quenching 1O2. To investigate the characteristic structure in the mechanism of quenching 1O2, the resveratrol, pterostilbene and piceatannol quenching 1O2 abilities were compared by UHPLC-QTOF-MS2 and UHPLC-QQQ-MS2. Results showed that catechol, carbon-carbon double bond and resorcinol participated in the quenching of 1O2. Catechol ring plays a leading role in the mechanism, and the contribution of the structures in quenching 1O2 activity are as follows: catechol ring > carbon-carbon double bond > resorcinol ring, which is supported by the calculation of energy. Our findings will contribute to the future screening of stilbenes with higher activity, and those stilbenes may have great therapeutic potential in 1O2-mediated diseases.

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A near infrared singlet oxygen probe and its applications in in vivo imaging and measurement of singlet oxygen quenching activity of flavonoids

Cited by 25 publications

References 32 publications

Silica coating of indium phosphide nanoparticles by a sol–gel method and their photobleaching properties

Silica coating of indium phosphide nanoparticles by a sol–gel method and their photobleaching properties

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

Carbon-Carbon Double Bond and Resorcinol in Resveratrol and Its Analogues: What Is the Characteristic Structure in Quenching Singlet Oxygen?

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