A near-infrared phthalocyanine dye-labeled agent for integrin αvβ6-targeted theranostics of pancreatic cancer

Gao, Duo; Gao, Liquan; Zhang, Chenran; Líu, Hao; Jia, Bing; Zhu, Zhenggang; Wang, Fan; Liu, Zhaofei

doi:10.1016/j.biomaterials.2015.02.093

Cited by 37 publications

(27 citation statements)

References 35 publications

(40 reference statements)

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“…It was found through in vitro, in vivo, and ex vivo fluorescence and optical imaging and ex vivo PET scans that the targeted phthalocyanine system did successfully bind to αvβ 6 integrin, which is widely upregulated in cancers, especially pancreatic cancer. 178 In another investigation, silica nanoparticles with encapsulated salicylaldehyde were surface modified with a DNA aptamer that selectively binds to nucleolin. MCF-7 cancer cells, which overexpress nucleolin, in comparison with normal MCF-10A cells were used to evaluate the targeting efficiency of the functionalized nanoparticles.…”

Section: Targetingmentioning

confidence: 99%

Mini-review: fluorescence imaging in cancer cells using dye-doped nanoparticles

2016

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Fluorescence imaging has gained increased attention over the past two decades as a viable means to detect a variety of cancers. Fluorescence imaging has the potential to provide physicians with high resolution images with enhanced contrast, which will allow them to be able to better diagnose and treat patients with cancer. Early detection and treatment are key to erradicating cancer in a patient, and fluorescence imaging has the ability to identify non-advanced, even pre-cancerous, tumors where imaging based on white light or radiation overlooked them. Several fluorescent dyes have been identified as possible fluorophores for enhanced fluorescence imaging, such as cyanine, squaraine, porphyrin, phthalocyanine, and borondipyrromethane dyes. These dyes have high fluorescence quantum yields, which provides a high target to background ratio; however, these dyes are often plagued by low water solubility. This low solubility can be ameliorated by conjugating or covalently attaching these dyes to polymeric crosslinked micelles, polymersomes, or polymer-core nanoparticles. These particle & dye systems then can become platforms on which secondary components can be attached to enhance the systems functionality. For example, dyes attached to these nanocarriers can target tumors through passive targeting; however, active targeting can be achieved by further modifying these nanocarriers with ligands that have a binding affinity for receptors overexpressed in tumor cells, cell surface receptors located on the tumor cell membrane, or endothelium. Fluorescence activation of the probes is another promising technology for the early detection of cancer. Activation requires that there be a change in fluorescence, whether it be an emission wavelength change or a fluorescence "on/off" signal when in the presence of some external stimuli. Activation increase the target to background ratio and enhances the contrast of the obtained image. This review serves to highlight the recent developments of (1) improved fluorescent dyes for the detection of cancer, with a specific focus on dyes that are being coupled to nanocarriers; (2) dye & nanocarrier systems that target, both actively and passively, tumors, and (3) fluorescence activation of these fluorophore systems for better image quality.

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Section: Targetingmentioning

confidence: 99%

Mini-review: fluorescence imaging in cancer cells using dye-doped nanoparticles

2016

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“…Integrin alphavbeta6 (αvβ 6 ) is one of cell surface receptors low expressed in the mature tissue, but significantly up-regulated in PDAC, which was considered to be a promising target for diagnostic imaging and therapy [21,22]. i)Peptide NAVPNLRGDLQVLAQKVART (A20FMDV2) was derived from foot-and-mouth disease virus with 20 amino acids, which presented a potent inhibition of αvβ6 ( IC 50 3 nmol/L) was identified by the Hausner group [20].…”

Section: Targeting αVβ 6 Integrinmentioning

confidence: 99%

PET Imaging in Pancreatic Cancer

Li¹,

Wang²

2019

SDRP-JFST

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Early accurate detection of pancreatic cancer is still a challenge for current medicine. Compared to conventional anatomical imaging techniques, PET can provide information on tumor function, and PET/CT is increasingly used in detecting and staging of cancer as single "one stop shop" method. In this review, we summarize current PET molecular imaging tracers or probes for pancreatic cancer detection, and a perspective of the future trend of pancreatic cancer target-specific probes in the clinic is also provided.

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“…The HSA NIRF imaging probe was prepared according to a previously described protocol (30,31). Briefly, HSA was mixed with IRDye800-N-hydroxysuccinimide (NHS) (LI-COR, Inc.) at a molar ratio of 1: 10 in sodium bicarbonate solution (pH 8.4).…”

Section: Macrophage Sorting and Adoptive Transfermentioning

confidence: 99%

Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy

et al. 2017

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Increased recruitment of tumor-associated macrophages (TAM) to tumors following chemotherapy promotes tumor resistance and recurrence and correlates with poor prognosis. TAM depletion suppresses tumor growth, but is not highly effective due to the effects of tumorigenic mediators from other stromal sources. Here, we report that adoptive macrophage transfer led to a dramatically enhanced photodynamic therapy (PDT) effect of 2-(1-hexyloxyethyl)-2-devinyl pyropheophor-bide-alpha (HPPH)-coated polyethylene glycosylated nanographene oxide [GO(HPPH)-PEG] by increasing its tumor accumulation. Moreover, tumor treatment with commonly used chemotherapeutic drugs induced an increase in macrophage infiltration into tumors, which also enhanced tumor uptake and the PDT effects of GO(HPPH)-PEG, resulting in tumor eradication. Macrophage recruitment to tumors after chemotherapy was visualized noninvasively by near-infrared fluorescence and single-photon emission CT imaging using F4/80-specific imaging probes. Our results demonstrate that chemotherapy combined with GO(HPPH)-PEG PDT is a promising strategy for the treatment of tumors, especially those resistant to chemotherapy. Furthermore, TAM-targeted molecular imaging could potentially be used to predict the efficacy of combination therapy and select patients who would most benefit from this treatment approach. .

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A near-infrared phthalocyanine dye-labeled agent for integrin αvβ6-targeted theranostics of pancreatic cancer

Cited by 37 publications

References 35 publications

Mini-review: fluorescence imaging in cancer cells using dye-doped nanoparticles

Mini-review: fluorescence imaging in cancer cells using dye-doped nanoparticles

PET Imaging in Pancreatic Cancer

Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy

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