A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death

Mbaveng, Armelle T.; Ndontsa, Blanche Laure; Kuete, Victor; Nguekeu, Yves Martial Mba; Çelik, İlhami; Mbouangouere, Roukayatou; Tane, Pierre; Efferth, Thomas

doi:10.1016/j.phymed.2018.03.035

Cited by 98 publications

(67 citation statements)

References 40 publications

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“…In conclusion, this is the first report on the bioassay of saponin XII. The results indicate that this compound inhibits the cell growth of OCI-AML cells by an increase of apoptosis—a known effect of saponins that is exerted through caspase 3/8/9 activation [ 13 , 21 ]. This effect is shown in particular by Dipsacus saponins as previous studies demonstrate that Dipsacus saponins decrease apoptosis by increasing the anti-apoptotic molecule Bcl-2, decreasing the expression of pro-apoptotic molecules Bax, caspase-9 and caspase-8 [ 22 ], and by decreasing proliferation.…”

Section: Resultsmentioning

confidence: 99%

“…Recent pharmacological studies demonstrate that the main saponin constituents isolated from the Dipsacus genus possess potent cytotoxic activities against tumor cell lines (A549, H157, HepG2 and MCF-7) and several additional promising activities [ 12 , 13 , 14 ]. The triterpenoid saponins, particularly those isolated from member of the Dipsacus genus, have demonstrated various pharmacological activities, such as antinociceptive and cardioprotective cytotoxic activities [ 12 , 13 , 14 ]. Among saponins, saponin XII was first isolated from Dipsacus asper Wall and its biological activities were unclear [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Cell Growth Inhibition of Saponin XII from Dipsacus japonicus Miq. on Acute Myeloid Leukemia Cells

et al. 2020

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In previous studies, we isolated the known compound saponin XII from the roots of Dipsacus japonicus Miq. Here, we show that this compound reduced the number of acute myeloid leukemia OCI-AML3 cells as evaluated by a hemocytometer. Flow cytometry analyses demonstrated that the reported activity was associated with a significant increase of apoptosis and of cells in the G0/G1 phase of the cell cycle, with a decrease of cells in the S and G2/M phases. Thus, the inhibition of cell growth in OCI-AML3 cells was due to antiproliferative and pro-apoptotic effects. Interestingly, the bioactivity of saponin XII exerted its effect at a concentration as low as 1 µg/mL.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cell Growth Inhibition of Saponin XII from Dipsacus japonicus Miq. on Acute Myeloid Leukemia Cells

et al. 2020

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“…In order to relieve the oxidative injury of conventional chemotherapeutic agents on BM hematopoietic tissues, research is underway to screen and develop natural components and biological products with antitumor effects, such as catechins, parthenolide, curcumin, and resveratrol [116][117][118][119][120][121][122][123][124][125][126][127][128][129][130][131][132][133][134][135] . The role of these natural antitumor drugs in inducing the apoptosis of tumor cells is also related to ROS.…”

Section: Oxidative Injury Of Hscs Caused By Pro-oxidative Treatmentmentioning

confidence: 99%

Oxidative resistance of leukemic stem cells and oxidative damage to hematopoietic stem cells under pro-oxidative therapy

et al. 2020

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Leukemic stem cells (LSCs) and hematopoietic stem cells (HSCs) are both dependent on the hypoxic bone marrow (BM) microenvironment (also known as the BM niche). There is always fierce competition between the two types of cells, and the former exhibits a greater competitive advantage than the latter via multiple mechanisms. Under hypoxia, the dynamic balance between the generation and clearing of intracellular reactive oxygen species (ROS) is conducive to maintaining a quiescent state of cells. Quiescent LSCs can reside well in the BM niche, avoiding attack by chemotherapeutic agents, which is the cause of chemotherapeutic resistance and relapse in leukemia. HSCs acquire energy mainly through anaerobic glycolysis, whereas LSCs achieve energy metabolism largely through mitochondrial oxidative respiration. Mitochondria are the primary site of ROS generation. Thus, in theory, mitochondria-mediated respiration will cause an increase in ROS generation in LSCs and a higher intracellular oxidative stress level. The sensitivity of the cells to pro-oxidant drugs increases as well, which allows for the selective clearing of LSCs by prooxidative therapy. However, HSCs are also highly sensitive to changes in ROS levels, and the toxic effects of prooxidant drugs on HSCs poses a major challenge to pro-oxidative therapy in leukemia. Given the above facts, we reviewed studies on the oxidative resistance of LSCs and the oxidative damage to HSCs under pro-oxidative therapy. An in-depth investigation into the oxidative stress status and regulatory mechanisms of LSCs and HSCs in hypoxic environments will promote our understanding of the survival strategy employed by LSCs and the mechanism of the oxidative damage to HSCs in the BM niche, thus facilitating individualized treatment of leukemia patients and helping eliminate LSCs without disturbing normal hematopoietic cells.

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“…The change in the mitochondrial membrane potential in MCF-7 cells exposed to Se@b-CD-FA@PTX was detected by JC-1, as previously reported. 38,39 The cells were harvested by centrifugation, resuspended in PBS and analyzed by ow cytometry. The percentage of the green uorescence from the JC-1 monomers was used to represent the cells that lost DJ m .…”

Section: Mitochondrial Membrane Potential (Dj M )mentioning

confidence: 99%

Targeted delivery of paclitaxel by functionalized selenium nanoparticles for anticancer therapy through ROS-mediated signaling pathways

Gong

Ying

et al. 2018

RSC Adv.

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A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death

Cited by 98 publications

References 40 publications

Cell Growth Inhibition of Saponin XII from Dipsacus japonicus Miq. on Acute Myeloid Leukemia Cells

Cell Growth Inhibition of Saponin XII from Dipsacus japonicus Miq. on Acute Myeloid Leukemia Cells

Oxidative resistance of leukemic stem cells and oxidative damage to hematopoietic stem cells under pro-oxidative therapy

Targeted delivery of paclitaxel by functionalized selenium nanoparticles for anticancer therapy through ROS-mediated signaling pathways

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