A Naturalistic Evaluation of Intramuscular Ziprasidone Versus Intramuscular Olanzapine for the Management of Acute Agitation and Aggression in Children and Adolescents

Khan, Shamima S.; Mican, Lisa M.

doi:10.1089/cap.2006.16.671

Cited by 43 publications

(38 citation statements)

References 10 publications

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“…Other rare side-effects included seizure risk, muscle aches, and bleeding from the nose [19,21]. No changes in EKG or blood pressure with ziprasidone were documented in this retrospective chart review [19]. Olanzapine was found to cause weight gain [28].…”

Section: Side Effectsmentioning

confidence: 78%

“…The most common side-effect with ziprasidone is feeling drowsy [21]. Other rare side-effects included seizure risk, muscle aches, and bleeding from the nose [19,21]. No changes in EKG or blood pressure with ziprasidone were documented in this retrospective chart review [19].…”

Section: Side Effectsmentioning

confidence: 83%

“…Surprisingly, the study concluded that benadryl was equally effective as placebo in treating aggression in children [18]. However, using ziprasidone (an atypical antipsychotic) intramuscularly has been found to be beneficial for acute management of child and adolescent inpatient aggression [19][20][21][22][23]. IM olanzapine has been found to be equally effective as IM ziprasidone [19].…”

Section: Child Becoming Frustrated Child Has Become Aggressive/agitatedmentioning

confidence: 99%

“…However, using ziprasidone (an atypical antipsychotic) intramuscularly has been found to be beneficial for acute management of child and adolescent inpatient aggression [19][20][21][22][23]. IM olanzapine has been found to be equally effective as IM ziprasidone [19]. PO risperidone (risperdal) [24,25], PO haloperidol (haldol) [26], PO lithium carbonate (eskalith) [26,27] and PO olanzapine [28] were found to be beneficial in reducing inpatient aggressive episodes after treatment for more than 4 weeks and hence limits their usefulness on acute inpatient treatment units.…”

Section: Child Becoming Frustrated Child Has Become Aggressive/agitatedmentioning

confidence: 99%

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Collaborative Problem Solving (CPS) as a Primary Method of Addressing Acute Pediatric Pathological Aggression Along with Other Modalities

2010

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The answer for treating pathologic aggression (PA) in children on inpatient psychiatry units (based on various factors like severity of aggression and co-morbidities) is less likely to be restrictive interventions or sedating the patient. Using seclusion and restraints or medications to calm down the aggression is not free of adverse consequences. A protocol is needed to safely and effectively address aggressive and violent children and adolescents seen very commonly in psychiatry inpatient units.

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Section: Side Effectsmentioning

confidence: 78%

Section: Side Effectsmentioning

confidence: 83%

Section: Child Becoming Frustrated Child Has Become Aggressive/agitatedmentioning

confidence: 99%

Section: Child Becoming Frustrated Child Has Become Aggressive/agitatedmentioning

confidence: 99%

See 2 more Smart Citations

Collaborative Problem Solving (CPS) as a Primary Method of Addressing Acute Pediatric Pathological Aggression Along with Other Modalities

2010

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“…Khan and Mican16 compared the efficacy and safety of intramuscular ziprasidone 10 or 20 mg (n=50) with intramuscular olanzapine 10 mg (n=50) in treating aggression from 2003 to 2005 on an inpatient child and adolescent psychiatry unit with an average LOS of 30 days. More children (≤12 years) were in the olanzapine group (n=15; mean age for total group 13.7±2.4) compared with the ziprasidone group (n=5; mean age 14.6±2.1).…”

Section: Resultsmentioning

confidence: 99%

What do we really know about PRN use in agitated children with mental health conditions: a clinical review

Baker

Carlson

2018

Evid Based Mental Health

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What is the evidence that ‘pro re nata’ (PRN) medication is effective for ending agitated outbursts in children and adolescents in psychiatric emergency rooms or inpatient units? Literature search was performed for studies of PRN medication use in children and adolescents that included an outcome measure. One randomised controlled trial, three prospective studies and six retrospective studies that included some outcome measure were identified. Outcome measures were heterogeneous, and frequently did not use standardised metrics assessing agitation level to measure effectiveness. The single small Randomized Controlled Trial (RTC) does not find a difference between placebo and medication, and outcomes of other studies do not control for potential placebo effect of the intervention itself as opposed to the medication. There is insufficient evidence to support the common practice of PRN medications for the management of acute agitation, and no data with which to inform clinical practice, such as which medicines and doses are helpful for specific populations or situations. Psychiatrists have no evidence-based medication interventions for acutely managing agitated outbursts in children and adolescents.

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Children and Adolescents

2021

The Maudsley Prescribing Guidelines in Psychiatry

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Approximately 15% of young people experience depression by age 18 and these young people often have significant functional impairment and risk of harm. Bipolar depression is a common clinical challenge and its treatment has been studied much less in youth compared than in adults. Schizophrenia is rare in children but the incidence increases rapidly in adolescence. Algorithms for treating psychosis in children and adolescents are the same as those for adult patients. Anxiety symptoms in children and adolescents often improve with age, presumably in parallel to the development of the prefrontal cortex and, in particular, executive function. Treatment of anxiety disorders in pre‐school children must routinely focus on psychotherapy. The treatment of obsessive compulsive disorder (OCD) and body dysmorphic disorder (BDD) in children and adolescents follows the same principles as in adults. Discontinuing medication is very typically associated with a deterioration in symptoms of OCD or BDD.

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A Naturalistic Evaluation of Intramuscular Ziprasidone Versus Intramuscular Olanzapine for the Management of Acute Agitation and Aggression in Children and Adolescents

Cited by 43 publications

References 10 publications

Collaborative Problem Solving (CPS) as a Primary Method of Addressing Acute Pediatric Pathological Aggression Along with Other Modalities

Collaborative Problem Solving (CPS) as a Primary Method of Addressing Acute Pediatric Pathological Aggression Along with Other Modalities

What do we really know about PRN use in agitated children with mental health conditions: a clinical review

Children and Adolescents

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