A natural small molecule inhibitor corilagin blocks HCV replication and modulates oxidative stress to reduce liver damage

Reddy, B Uma; Mullick, Ranajoy; Kumar, Anuj; Sharma, G. D.; Bag, Paromita; Roy, Chaitrali Laha; Sudha, G.; Tandon, Himani; Dave, Pratik; Shukla, Avanish; Srinivasan, Priyanka; Madhusudhan, Nandhitha; Srinivasan, Narayanaswamy; Das, Saumitra

doi:10.1016/j.antiviral.2017.12.004

Cited by 40 publications

(34 citation statements)

References 35 publications

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“…Indeed, several natural compounds, including sophocarpine and tomatidine, inhibited osteolysis and osteoporosis in animal models 6 . Corilagin shows promise as a medicinal herbal agent against various diseases 8,30,38 . Jia et al reported that Corilagin inhibited the growth of SKOv3ip ovarian cancer cells in vitro and of xenograft tumours in vivo 30 .…”

Section: Discussionmentioning

confidence: 99%

“…Jia et al reported that Corilagin inhibited the growth of SKOv3ip ovarian cancer cells in vitro and of xenograft tumours in vivo 30 . Reddy et al reported that Corilagin blocked hepatitis C viral replication and protected against liver damage by modulating oxidative stress 38 . Corilagin also reportedly ameliorated nutritional steatohepatitis in vitro and in vivo 8 .…”

Section: Discussionmentioning

confidence: 99%

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Corilagin suppresses RANKL‐induced osteoclastogenesis and inhibits oestrogen deficiency‐induced bone loss via the NF‐κB and PI3K/AKT signalling pathways

Huang

et al. 2020

J Cellular Molecular Medi

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Over‐activated osteoclastogenesis, which is initiated by inflammation, has been implicated in osteoporosis. Corilagin, a natural compound extracted from various medicinal herbaceous plants, such as Cinnamomum cassia, has antioxidant and anti‐inflammatory activities. We found that Corilagin suppressed osteoclast differentiation in a dose‐dependent manner, significantly decreased osteoclast‐related gene expression and impaired bone resorption by osteoclasts. Moreover, phosphorylation of members of the nuclear factor‐kappaB (NF‐κB) and PI3K/AKT signalling pathways was reduced by Corilagin. In a murine model of osteoporosis, Corilagin inhibited osteoclast functions in vivo and restored oestrogen deficiency‐induced bone loss. In conclusion, our findings suggested that Corilagin inhibited osteoclastogenesis by down‐regulating the NF‐κB and PI3K/AKT signalling pathways, thus showing its potential possibility for the treatment of osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Corilagin suppresses RANKL‐induced osteoclastogenesis and inhibits oestrogen deficiency‐induced bone loss via the NF‐κB and PI3K/AKT signalling pathways

Huang

et al. 2020

J Cellular Molecular Medi

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“…Particularly, the hepatoprotective effect of Cori has been brought into focus by current research. Several studies reported the protective role of Cori against hepatocellular carcinoma (HCC) (Ming et al, 2013), hepatic injury following hemorrhagic shock (Liu et al, 2017), schistosomiasis hepatic fibrosis (Li et al, 2017), and hepatitis c virus (HCV) infection (Reddy et al, 2018). However, whether Cori possesses the therapeutic potential for the treatment of NAFLD has not been reported yet.…”

Section: Introductionmentioning

confidence: 99%

Corilagin Alleviates Nonalcoholic Fatty Liver Disease in High-Fat Diet-Induced C57BL/6 Mice by Ameliorating Oxidative Stress and Restoring Autophagic Flux

et al. 2020

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Corilagin (Cori) possesses multiple biological activities. To determine whether Cori can exert protective effects against nonalcoholic fatty liver disease (NAFLD) and its potential mechanisms. C57BL/6 mice were fed with high-fat diet (HFD) alone or in combination with Cori (20 mg/kg, i.p.) and AML12 cells were exposed to 200 mM PA/OA with or without Cori (10 mM or 20 mM). Phenotypes and key indicators relevant to NAFLD were examined both in vivo and in vitro. In this study, Cori significantly ameliorated hepatic steatosis, confirmed by improved serum lipid profiles, and hepatic TC, TG contents, and the gene expression related to lipid metabolism in livers of HFD mice. Moreover, Cori attenuated HFD-mediated autophagy (including mitophagy) blockage by restoring autophagic flux, evidenced by increased number of autophagic double vesicles containing mitochondria, elevated LC3II protein levels, decreased p62 protein levels, as well as enhanced colocalization of autophagy-related protein (LC3, Parkin) and mitochondria. In accordance with this, Cori also reduced the accumulation of ROS and MDA levels, and enhanced the activities of antioxidative enzymes including SOD, GSH-Px, and CAT. In addition, Cori treatment improved mitochondrial dysfunction, evidenced by increased mitochondrial membrane potential (DYm). In parallel with this, Cori decreased mitochondrial DNA oxidative damage, while increased mitochondrial biogenesis related transcription factors expression, mitochondrial DNA content and oxygen consumption rate (OCR). In conclusion, these results demonstrate that Cori is a potential candidate for

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“…To scientifically support the traditional use of P. amarus, several pharmacological studies were conducted with extracts from the leaves and compounds isolated thereof. Antiallodynic [10], antiinflammatory [11], analgesic [12], cardioprotective [13], hepatoprotective [14], antioxidant [15], cytotoxic [16,17], immunosuppressive [18,19], antiparasitic [20,21], antiviral [22,23], antibacterial [24,25] antidiabetic [26], antihypertensive [27], chondroprotective [28], osteogenic [29], and diuretic properties [30] have been reported for the constituents of P. amarus.…”

Section: Prospecting and Identifying Phyllanthus Amarus Lignans With mentioning

confidence: 99%

“…Among the lignans tested against Trypanosoma cruzi intracellular amastigotes, 2 was the most active with an EC 50 of 35.28 µM. Lignans 2, 5, 7, and 9 showed inhibitory effects against Leishmania amazonensis promastigotes with EC 50 of 56.34, 51.86, 23.57, and 43.27 µM, respectively. During in vitro infection assays, 5 reduced amastigotes by 91 % at 103.68 µM concentration, whereas 7 and 9 reduced amastigotes by approximately 84 % at 47.5 and 86.04 µM, respectively.…”

Section: Introductionmentioning

confidence: 99%

Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity

et al. 2020

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Ten lignans (1 – 10) were isolated from the hexane-ethyl acetate extract of Phyllanthus amarus leaves. Three of them, cubebin dimethyl ether (3), urinatetralin (4), and lintetralin (7) are described for the first time in this species, while phyllanthin (1), niranthin (2), 5-demethoxyniranthin (5), isolintetralin (6), hypophyllanthin (8), nirtetralin (9), and phyltetralin (10) have been already reported from P. amarus. Among the lignans tested against Trypanosoma cruzi intracellular amastigotes, 2 was the most active with an EC50 of 35.28 µM. Lignans 2, 5, 7, and 9 showed inhibitory effects against Leishmania amazonensis promastigotes with EC50 of 56.34, 51.86, 23.57, and 43.27 µM, respectively. During in vitro infection assays, 5 reduced amastigotes by 91% at 103.68 µM concentration, whereas 7 and 9 reduced amastigotes by approximately 84% at 47.5 and 86.04 µM, respectively. Lignans 5, 7, and 9 were more potent in intracellular amastigotes with EC50 of 2.76, 8.30, and 15.83 µM, respectively, than in promastigotes. CC50 for all samples was > 100 µg/mL, thus revealing low cytotoxicity against macrophages, and selectivity against the parasite. L. amazonensis promastigotes treated with compounds 2 and 9 showed decreased respiratory control of 38% and 25%, respectively, suggesting a change in mitochondrial membrane potential and lower ATP production.

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A natural small molecule inhibitor corilagin blocks HCV replication and modulates oxidative stress to reduce liver damage

Cited by 40 publications

References 35 publications

Corilagin suppresses RANKL‐induced osteoclastogenesis and inhibits oestrogen deficiency‐induced bone loss via the NF‐κB and PI3K/AKT signalling pathways

Corilagin suppresses RANKL‐induced osteoclastogenesis and inhibits oestrogen deficiency‐induced bone loss via the NF‐κB and PI3K/AKT signalling pathways

Corilagin Alleviates Nonalcoholic Fatty Liver Disease in High-Fat Diet-Induced C57BL/6 Mice by Ameliorating Oxidative Stress and Restoring Autophagic Flux

Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity

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