A natural protein based platform for the delivery of Temozolomide acid to glioma cells

Helal, Dina O.; Rouatbi, Nadia; Han, Shunping; Wang, Julie; Walters, Adam A.; Abdel-Mottaleb, Mona M.A.; Kamel, Amany O.; Geneidi, Ahmed S.; Awad, Gehanne A.S.; Al‐Jamal, Khuloud T.

doi:10.1016/j.ejpb.2021.10.007

Cited by 13 publications

(8 citation statements)

References 57 publications

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“…In brief, mice ∼ 6–8 weeks age were injected with 400k cells into the right hemisphere. Starting from the bregma the stereotactic coordinates were as follows: 3 mm anterior, 1mm lateral, and 3 mm deep 29 . Roughly 2–3 weeks after the implantation of the tumours, animals were humanely sacrificed and the brains were collected and frozen in - 20° C. All animal experiments were performed under the authority of project licence (PBE6EB195 - Prof. Al Jamal Khuloud) and personal licence (I13B24EFC – Miss.…”

Section: Methodsmentioning

confidence: 99%

Nondestructive Spatial Lipidomics for Glioma Classification

Martella

Rose

Rouatbi

et al. 2023

Preprint

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Mapping the molecular composition of tissues using spatial biology provides high-content information for molecular diagnostics. However, spatial biology approaches require invasive procedures to collect samples and destroy the investigated tissue, limiting the extent of analysis, particularly for highly functional tissues such as those of the brain. To address these limitations, we developed a workflow to harvest biomolecules from brain tissues using nanoneedles and characterise the distribution of lipids using desorption electrospray ionization mass spectrometry imaging. The nanoneedles preserved the original tissue while harvesting a reliable molecular profile and retaining the original lipid distribution for mouse and human brain samples, accurately outlining the morphology of key regions within the brain and tumour lesions. The deep neural network analysis of a cohort containing 23 human glioma biopsies showed that nanoneedle samples maintain the molecular signatures required to accurately classify disease state. Thus, nanoneedles provide a route for tissue-preserving spatial lipidomic and molecular diagnostics.

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Section: Methodsmentioning

confidence: 99%

Nondestructive Spatial Lipidomics for Glioma Classification

Martella

Rose

Rouatbi

et al. 2023

Preprint

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“…The NPs labeled by fluorescent dye co-localized with the bioluminescent syngeneic BL6 intracranial GBM model after intravenous treatment. 129 Byeon et al synthesized a dendrimer-cationized-albumin (dCatAlb) by the carboxyl activating method. The prepared dCatAlb particles were encapsulated using a PLGA nanoparticle core loaded with DOX.…”

Section: Biomaterials Sciencementioning

confidence: 99%

Advanced biomaterials for human glioblastoma multiforme (GBM) drug delivery

et al. 2023

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Section: Nanoparticles and Glioma Chemotherapymentioning

confidence: 99%

“…After 72 h of incubation, the chosen formula showed high cytotoxicity, with 20% cell viability at 1 mM TMZA. Finally, after intravenous delivery, the fluorescently labelled NPs displayed co-localization with the bioluminescent syngeneic BL6 intracranial tumour mouse model [53]. Nanomedicines are a promising way to deliver different therapeutic modalities to tumours in a safe and regulated manner by releasing cytotoxic payloads only in tumour tissue.…”

Section: Nanoparticles and Glioma Chemotherapymentioning

confidence: 99%

Multimodal targeting of glioma with functionalized nanoparticles

Marei

2022

Cancer Cell Int

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The most common and aggressive primitive intracranial tumor of the central nervous system is the glioma. The blood–brain barrier (BBB) has proven to be a significant obstacle to the effective treatment of glioma. To effectively treat glioma, different ways have been used to cross the BBB to deliver drugs to the brain. Drug delivery through nanocarriers proves to be an effective and non-invasive technique for the treatment of glioma and has great potential in the treatment of glioma. In this review, we will provide an overview of nanocarrier-mediated drug delivery and related glioma therapy. Nanocarrier-mediated drug delivery techniques to cross the BBB (liposomes, micelles, inorganic systems, polymeric nanoparticles, nanogel system, and biomimetic nanoparticles) are explored. Finally, the use of nanotherapeutic approaches in the treatment of glioblastoma including chemotherapy, radiotherapy, photothermal therapy, gene therapy, glioma genome editing, immunotherapy, chimeric antigen receptor (CAR) T-cells, immune checkpoint modulators, immune photothermal therapy, vaccine-based immunotherapy, and combination therapy is summarized. Furthermore, this article offers various views on the clinical applicability of nanomedicine.

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A natural protein based platform for the delivery of Temozolomide acid to glioma cells

Cited by 13 publications

References 57 publications

Nondestructive Spatial Lipidomics for Glioma Classification

Nondestructive Spatial Lipidomics for Glioma Classification

Advanced biomaterials for human glioblastoma multiforme (GBM) drug delivery

Multimodal targeting of glioma with functionalized nanoparticles

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