A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice

Valencia-Hernandez, Ana Maria; Ng, Wei Yi; Ghazanfari, Nazanin; Ghilas, Sonia; Menezes, Melody; Holz, Lauren E.; Huang, Cheng; English, Kieran; Naung, Myo; Tan, Peter; Tullett, Kirsteen M.; Steiner, Thiago M.; Enders, Matthias H.; Beattie, Lynette; Chua, Yu Cheng; Jones, Claerwen M.; Cozijnsen, Anton; Mollard, Vanessa; Cai, Yiyong; Bowen, David G.; Purcell, Anthony W.; Gruta, Nicole L. La; Villadangos, José A; Koning-Ward, Tania de; Barry, Alyssa E.; Barchet, Winfried; Cockburn, Ian A.; McFadden, Geoffrey I.; Gras, Stéphanie; Lahoud, Mireille H.; Bertolino, Patrick; Schittenhelm, Ralf B.; Caminschi, Irina; Heath, William R.; Fernandez‐Ruiz, Daniel

doi:10.1016/j.chom.2020.04.010

Cited by 49 publications

(59 citation statements)

References 62 publications

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“…These studies have also demonstrated that substantial numbers of liver T RM cells are associated with higher levels of immunity to malaria, and depletion of these cells ablates protection [6,9]. Based on these results, several complex vaccinations strategies, aimed at trapping activated CD8 + T cells in the liver, have now successfully induced the formation of liver T RM cells in mice [6][7][8][9]. One vaccination strategy, prime-and-trap, is a single injection of a 3-component vaccine designed to prime Plasmodium-specific CD8 + T cells in the spleen and recruit them to the liver to form T RM cells via locally expressed antigen recognition and adjuvant-induced inflammation [6,9].…”

Section: Liver T Rm Cell Immune Responses To Infectionmentioning

confidence: 98%

Section: Liver T Rm Cell Immune Responses To Infectionmentioning

confidence: 99%

“…Murine studies have shown that liver T RM cells can confer efficient protection against liver-stage Plasmodium infection [6,9]. These studies have also demonstrated that substantial numbers of liver T RM cells are associated with higher levels of immunity to malaria, and depletion of these cells ablates protection [6,9]. Based on these results, several complex vaccinations strategies, aimed at trapping activated CD8 + T cells in the liver, have now successfully induced the formation of liver T RM cells in mice [6][7][8][9].…”

Section: Liver T Rm Cell Immune Responses To Infectionmentioning

confidence: 99%

“…By combining transcriptional and phenotypic features with different approaches to investigate residency, studies have identified T RM cells in various disease models and within several tissue settings, including the liver. Importantly, strategies have been devised to favour the formation of T RM cells through vaccination, achieving promising results, for example, in the case of herpes virus infection in the mucosa of the female genital tract [4] and Plasmodium infection of the liver [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Resident Memory T Cells and Their Role within the Liver

Ghilas

Valencia-Hernandez

Enders

et al. 2020

IJMS

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Immunological memory is fundamental to maintain immunity against re-invading pathogens. It is the basis for prolonged protection induced by vaccines and can be mediated by humoral or cellular responses—the latter largely mediated by T cells. Memory T cells belong to different subsets with specialized functions and distributions within the body. They can be broadly separated into circulating memory cells, which pace the entire body through the lymphatics and blood, and tissue-resident memory T (TRM) cells, which are constrained to peripheral tissues. Retained in the tissues where they form, TRM cells provide a frontline defense against reinfection. Here, we review this population of cells with specific attention to the liver, where TRM cells have been found to protect against infections, in particular those by Plasmodium species that cause malaria.

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Section: Liver T Rm Cell Immune Responses To Infectionmentioning

confidence: 98%

Section: Liver T Rm Cell Immune Responses To Infectionmentioning

confidence: 99%

Section: Liver T Rm Cell Immune Responses To Infectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Resident Memory T Cells and Their Role within the Liver

Ghilas

Valencia-Hernandez

Enders

et al. 2020

IJMS

Self Cite

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“…A 'prime and trap' vaccination approach induced protective immunity against liver-stage malaria in a preclinical study. 4 T cells are first activated in the spleen with the ribosomal L6 protein from Plasmodium berghei, and then trapped in the liver to form resident memory cells. A single vaccine dose provided lasting protection from sporozoite challenge in a mouse model of malaria.…”

Section: New Vaccine Strategy Protects Mice From Malariamentioning

confidence: 99%

Human Vaccines & Immunotherapeutics: news

2020

Human Vaccines & Immunotherapeutics

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Cascade In Situ Self‐Assembly and Bioorthogonal Reaction Enable the Enrichment of Photosensitizers and Carbonic Anhydrase Inhibitors for Pretargeted Cancer Theranostics

Wen,

Zeng,

Zhang

et al. 2023

Angewandte Chemie

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We report here a tumor‐pretargted theranostic approach for multimodality imaging‐guided synergistic cancer PDT by cascade alkaline phosphatase (ALP)‐mediated in situ self‐assembly and bioorthogonal inverse electron demand Diels–Alder (IEDDA) reaction. Using the enzymatic catalysis of ALP that continuously catalyses the dephosphorylation and self‐assembly of trans‐cyclooctene (TCO)‐bearing P‐FFGd‐TCO, a high density of fluorescent and magnetic TCO‐containing nanoparticles (FMNPs‐TCO) can be synthesized and retained on the membrane of tumor cells. They can act as ‘artificial antigens’ amenable to concurrently capture lately administrated tetrazine (Tz)‐decorated PS (775NP‐Tz) and carbonic anhydrase (CA) inhibitor (SA‐Tz) via the fast IEDDA reaction. This two‐step pretargeting process can further induce FMNPs‐TCO regrowth into microparticles (FMNPs‐775/SA) directly on tumor cell membranes, which is analyzed by bio‐SEM and fluorescence imaging. Thus, efficient enrichment of both SA‐Tz and 775NP‐Tz in tumors can be achieved, allowing to alleviate hypoxia by continuously inhibiting CA activity and improving PDT of tumors. Findings show that subcutaneous HeLa tumors could be completely eradicated and no tumor recurred after irradiation with an 808 nm laser (0.33 W cm−2, 10 min). This pretargeted approach may be applied to enrich other therapeutic agents in tumors to improve targeted therapy.

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A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice

Cited by 49 publications

References 62 publications

Resident Memory T Cells and Their Role within the Liver

Resident Memory T Cells and Their Role within the Liver

Human Vaccines & Immunotherapeutics: news

Cascade In Situ Self‐Assembly and Bioorthogonal Reaction Enable the Enrichment of Photosensitizers and Carbonic Anhydrase Inhibitors for Pretargeted Cancer Theranostics

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