A natural killer cell receptor takes sharp aim at the world of bacteria

Parham, Peter

doi:10.1073/pnas.1907937116

Cited by 3 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…KIR2DS4 is the oldest human KIR gene and, unlike most KIR genes, has an orthologue in the chimpanzee (44). KIR2DS4 is known to interact with HLA-C2 and specifically C*04:01 and C*05:01 as well as HLA-A*11 (37,41,44,48,49). In our study, the magnitude of the effect of 2DL4*001:02 and 2DS4*001:01 was greatest when present in a child with C*04:01 (a C2 variant).…”

Section: Discussionmentioning

confidence: 99%

KIR Allelic Variation and the Remission of Atopic Dermatitis Over Time

et al. 2023

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a common chronic skin disease. Although generally thought to be a disease of T-cell dysregulation, recent studies have suggested that immune dysregulation of NK cells is also important. Killer cell Ig-like receptors (KIRs) are involved with NK cell regulation. The Pediatric Eczema Elective Registry is a U.S. nationwide longitudinal cohort with up to 10 y of follow-up in which 655 children had DNA available for full allelic KIR sequencing. Every 6 mo, AD activity was reported by Pediatric Eczema Elective Registry children. Using generalized estimating equations, we evaluated the association of KIR allelic variation in concert with known HLA binding ligands and whether the child reported AD in “remission” (no skin lesions and not using AD medication). KIR2DS4*001:01 (odds ratio 0.53, 95% CI [0.32, 0.88]) and KIR2DL4*001:02 (0.54, [0.33, 0.89]) in the presence of C*04:01 had the largest effect on decreasing the likelihood of AD remission. The haplotype KIR 2DL4*001:02 ∼ 2DS4*001:01 ∼ 3DL2*002:01 (0.77, [0.60, 0.99]) was also associated with a decreased likelihood of AD remission. Our findings add to the general body of evidence of a growing literature on the importance of NK cells with respect to the immunopathogenesis and natural history of AD.

show abstract

Section: Discussionmentioning

confidence: 99%

KIR Allelic Variation and the Remission of Atopic Dermatitis Over Time

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Thus, it appears that the KIR family is not only involved in NK cell licensing and in multiple disease associations, but also, most likely, in antibacterial defense. This paper received an accompanying Commentary by Peter Parham, which places the findings in the broader context of KIR and HLA class I molecules ( 100 ).…”

Section: A Human Kir Recognizes a Conserved Bacterial Epitopementioning

confidence: 99%

Airway Natural Killer Cells and Bacteria in Health and Disease

2020

View full text Add to dashboard Cite

Natural killer (NK) cells are innate lymphoid cells at the interface between innate and adaptive immunity and mostly studied for their important roles in viral infections and malignant tumors. They can kill diseased cells and produce cytokines and chemokines, thereby shaping the adaptive immune response. Nowadays, NK cells are considered as a strong weapon for cancer immunotherapy and can for example be transduced to express tumor-specific chimeric antigen receptors or harnessed with therapeutic antibodies such as the so-called NK engagers. Whereas a large body of literature exists about the antiviral and antitumoral properties of NK cells, their potential role in bacterial infections is not that well delineated. Furthermore, NK cells are much more heterogeneous than previously thought and have tissue-characteristic features and phenotypes. This review gives an overview of airway NK cells and their position within the immunological army dressed against bacterial infections in the upper and predominantly the lower respiratory tracts. Whereas it appears that in several infections, NK cells play a non-redundant and protective role, they can likewise act as rather detrimental. The use of mouse models and the difficulty of access to human airway tissues for ethical reasons might partly explain the divergent results. However, new methods are appearing that are likely to reduce the heterogeneity between studies and to give a more coherent picture in this field.

show abstract

Sorafenib attenuated the function of natural killer cells infiltrated in HCC through inhibiting ERK1/2

Wei

et al. 2019

International Immunopharmacology

View full text Add to dashboard Cite

A natural killer cell receptor takes sharp aim at the world of bacteria

Cited by 3 publications

References 12 publications

KIR Allelic Variation and the Remission of Atopic Dermatitis Over Time

KIR Allelic Variation and the Remission of Atopic Dermatitis Over Time

Airway Natural Killer Cells and Bacteria in Health and Disease

Sorafenib attenuated the function of natural killer cells infiltrated in HCC through inhibiting ERK1/2

Contact Info

Product

Resources

About