A natural hydrophobic deep eutectic solvent-based microextraction method integrated with a spectrofluorimetric technique for the determination of daclatasvir as a direct-acting hepatitis C antiviral drug in plasma samples

A novel microextraction technique aided by air agitation using a natural hydrophobic deep eutectic solvent for the extraction of fluvastatin and empagliflozin from plasma samples: application to pharmacokinetic and drug–drug interaction study

“…It is a fast and straightforward technique, requiring minimal sample preparation, making it cost-effective, time-efficient and not requiring skilled personnel if compared to HPLC. 50,51 Furthermore, the use of NDES as an extraction medium can enhance the solubility of drugs, improving their extraction efficiency. To evaluate the inuence of EMP on FLV levels, a pharmacokinetic study was conducted using rabbits.…”