A natural flavonoid present in unripe plantain banana pulp (Musa sapientum L. var. paradisiaca) protects the gastric mucosa from aspirin-induced erosions

Lewis, David; Fields, William N; Shaw, Graham P.

doi:10.1016/s0378-8741(99)00005-7

Cited by 120 publications

(64 citation statements)

References 8 publications

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“…On the 7 th day of treatment with the CMS gel, the wounds were almost healed (Figures 3 and 4) but in the control and placebo groups, the wounds were reduced only to 50% and 46% of the original size, respectively (Figure 4). These results are consistent with studies that demonstrate the healing effect of M. sapientum in gastric ulcers (Goel et al, 1986;Lewis et al, 1999;Mohan et al, 2006;Pannangpetch et al, 2001) and other wounds (Agarwal et al, 2009).…”

Section: Discussionsupporting

confidence: 91%

“…originates from Asia, but is widely grown in most countries, including Brazil (Jesus et al, 2004). The consumption of this fruit is great because of their nutritional value; its shell has been studied for treatment of gastrointestinal disorders (diarrhea, gastritis and gastric ulcers) (Best et al, 1984;Dadoo et al, 1995;Goel et al, 1986;Lewis et al, 1999;Pannangpetch et al, 2001) and commonly is used to treat wounds, especially in nipple fissures that arise during breastfeeding (Novak et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of post-surgical healing in rats using a topical preparation based on extract of Musa sapientum L., Musaceae, epicarp

Lino¹,

Corrêa²,

Archondo³

et al. 2011

Rev. bras. farmacogn.

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Abstract:Considering that oral preparations made with peel green bananas (e.g. flour and extracts) demonstrated healing effects on mucous membranes and skin, this study evaluated the healing and the antimicrobial property of a topical preparation based on extract of Musa sapientum L., Musaceae, (apple banana) in surgically induced wounds in the skin of male Wistar rats, 100 g. The extract was obtained by decoction, the presence of tannins was detected by phytochemical screening and 10% of the extract was incorporated into the carbopol gel (CMS gel). The processes of healing and bacterial isolation were evaluated in the following experimental groups: control (no treatment), treatment with placebo or with the CMS gel. The healing of surgical wounds treated with the CMS gel was faster when compared with the control and placebo groups and the treatment with CMS gel also inhibited the growth of pyogenic bacteria and enterobacteria in the wounds. The results indicate that the extract of Musa sapientum epicarp has healing and antimicrobial properties (in vivo), probably, due to tannins.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Evaluation of post-surgical healing in rats using a topical preparation based on extract of Musa sapientum L., Musaceae, epicarp

Lino¹,

Corrêa²,

Archondo³

et al. 2011

Rev. bras. farmacogn.

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“…Several studies have proved that the phytoconstituents such as saponins, tannins, terpenoids and flavonoids have been reported as gastroprotective agents [31][32][33][34]. As Salmalia malabarica showed a rich amount of these phytoconstituents, we focused on the anti-ulcerogenic potential using three ulcer-induced experimental models in rats.…”

Section: Discussionmentioning

confidence: 99%

“…This method is a well-substantiated ulcer model because it has been used by various researchers [5,31,[35][36][37][38][39][40]. Aspirin is used for the induction of ulcer.…”

Section: Discussionmentioning

confidence: 99%

Anti-Ulcerogenic Effects of Salmalia Malabarica in Gastric Ulceration - Pilot Study

et al. 2015

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Background. According to an estimation of the WHO, almost 80% of people globally are treated by traditional medicine. Objectives. We evaluated the anti-ulcerogenic potential of Salmalia malabarica extract in rats using aspirin-, alcohol-and pylorus ligation-induced ulcer models. Material and Methods. Two different doses (200 and 400 mg/kg body weight) of Salmalia malabarica extract was administered intraperitoneally (i.p.) to all 3 ulcer-induced models for 5 consecutive days. The anti-ulcerogenic potential in rats treated with 2 doses of Salmalia malabarica extract and omeprazole (20 mg/kg, i.p.) was determined and compared to the control groups. Results. Salmalia malabarica extract showed a significant decrease in ulcer index as compared to the control group in a dose-dependent manner. Salmalia malabarica extract also showed protection of 66.22% and 74.54% in asprin-, 73.79% and 78.14% in alcohol-and 68.94% and 78.84% in pylorus ligation-induced ulcers. However, omeprazole showed protection of 84.73%, 85.5% and 86.12% in aspirin-, alcohol-and pylorus ligation-induced ulcers, respectively. Furthermore, Salmalia malabarica extract significantly decreased the volume of gastric juice, free and total acidity, whereas it increased gastric pH when directly compared to the control group. Conclusions. Conclusively, Salmalia malabarica possesses anti-ulcerogenic, antisecretory, and cytoprotective potential and can be used as a supplement for the treatment of gastric ulcers in a dose dependent manner (Adv Clin Exp Med 2015, 24, 4, 595-605).

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“…Furthermore, a significant reduction of glutathione concentration in granulation tissues, percentage of wound area and increase in wound breaking strength [16] were observed in rats on a green banana diet. Green bananas are also reported to have potent anti-ulcer activity [18] which is attributed to the active ingredient flavonoid leucocyanidin [19]. Oral administration of green banana flour [20] or the natural flavonoid leucocyanidin isolated from green bananas, as well as synthetic leucocyanidin, all significantly increased the gastric mucus thickness in aspirin-induced gastric ulcer animals [21].…”

Section: Green Bananas and Health Benefitsmentioning

confidence: 99%

Let’s Go Bananas! Green Bananas and their Health Benefits

Apostolopoulos

Antonipillai

Tangalakis

et al. 2017

Prilozi

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Bananas have enormous health benefits as a food for both animals and humans. They have been used as a complimentary medicine to treat pathological conditions since ancient times. Recently, there has been increased interest in the scientific validity of the beneficial effects of bananas in alleviating and treating disease conditions including, ulcers, infections, diabetes, diarrhea, colitis and blood pressure. Herein, we write on the potential therapeutic and functional benefits of certain species of bananas when consumed green as well as considering the properties of extracts from the non-fruit parts of the plant. We conclude that green bananas appear to deliver an array of health and therapeutic benefits

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A natural flavonoid present in unripe plantain banana pulp (Musa sapientum L. var. paradisiaca) protects the gastric mucosa from aspirin-induced erosions

Cited by 120 publications

References 8 publications

Evaluation of post-surgical healing in rats using a topical preparation based on extract of Musa sapientum L., Musaceae, epicarp

Evaluation of post-surgical healing in rats using a topical preparation based on extract of Musa sapientum L., Musaceae, epicarp

Anti-Ulcerogenic Effects of Salmalia Malabarica in Gastric Ulceration - Pilot Study

Let’s Go Bananas! Green Bananas and their Health Benefits

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