A natural flavonoid and synthetic analogues protect the gastric mucosa from aspirin-induced erosions

Lewis, David; Shaw, Graham P.

doi:10.1016/s0955-2863(00)00133-9

Cited by 45 publications

(25 citation statements)

References 8 publications

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“…Anti-hyperglycemic effect of EMC may be due to the presence of phyto-constituents like tannins, saponins and flavonoids [20,21]. The phytochemical investigation of EMC showed the presence of tannins, alkaloids and flavonoids (i.e.…”

Section: Discussion Blood Glucosementioning

confidence: 99%

“…Musa cavendish is called as 'Sonkela' in local language (Son-Gold, Kela-Banana; named due to its golden yellow colour and pure quality aspects), having small in size but high in nutritional value due to high carbohydrate contents. Several flavonoids and related compounds (leucocyanidin, quercetin and its 3-Ogalactoside, 3-O-glucoside, and 3-O-rhamnosyl glucoside, gallocatechin) have been isolated from the unripe pulp and peel of plantain [19][20][21]. These phytochemicals have shown a protective action against diseases which involve oxidative stress like diabetes, hepatic disorders.…”

Section: Introductionmentioning

confidence: 99%

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Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit

Navghare

Dhawale

2016

Ind J Clin Biochem

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Musa cavendish, peels has local and traditional use to promote wound healing, hyperglycemia, ulceration etc. The present work investigated the lipid lowering; nephroprotective and glucose lowering properties of ethanolic extract of peels of Musa cavendish (EMC) in alloxan-induced diabetic rats. The EMC 250, 500 and 1000 mg/kg/day and the vehicle were administered orally to alloxan-induced diabetic rats (n = 6) for 3 weeks. Changes in plasma glucose, lipid profile along with kidney function before and after treatment with EMC were recorded. The ethanolic extract of peels of Musa cavendish reduced blood glucose, serum triglyceride, cholesterol, LDL cholesterol and creatinine levels and improvement in body weight, liver glycogen, serum HDL cholesterol, serum albumin and total protein level when compared with untreated rats. Musa cavendish has lipid lowering, nephroprotective and antidiabetic property by regulating glucose uptake in the liver and muscles by restoring the intracellular energy balance.

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Section: Discussion Blood Glucosementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit

Navghare

Dhawale

2016

Ind J Clin Biochem

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“…Studies by David et al .,[22] reported that Leucocyanidin and its synthetic hydroxyl ethylated and tetra allyl derivatives were found to protect the gastric mucosa from aspirin-induced erosions. Leucocyanidin and its hydroxyl ethylated and tetra allyl derivatives significantly increased mucus thickness.…”

Section: Discussionmentioning

confidence: 99%

Indigenous anti-ulcer activity of Musa sapientum on peptic ulcer

Prabha¹,

Karpagam²,

Varalakshmi³

et al. 2011

Phcog Res

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Background:Peptic ulcer disease (PUD), encompassing gastric and duodenal ulcers is the most prevalent gastrointestinal disorder. The pathophysiology of PUD involves an imbalance between offensive factors like acid, pepsin and defensive factors like nitric oxide and growth factors. The clinical evaluation of antiulcer drugs showed tolerance, incidence of relapses and side-effects that make their efficacy arguable. An indigenous drug like Musa sapientum possessing fewer side-effects is the major thrust area of present day research, aiming at a better and safer approach for the management of PUD.Material and Methods:The unripe plantain bananas (Musa sapientum) were shade-dried, powdered and used for phytochemical analysis and as antiulcer drug. In our present study Group I rats served as control and were treated with saline, Group II was indomethacin-induced ulcerated rats, Group III received aqueous extract of Musa sapientum along with indomethacin and Group IV received esomeprazole along with indomethacin for 21 days. The anti-ulcerogenic activity was investigated by performing hematological, mucosal, antioxidant profile in comparison with the standard drug esomeprazole.Results:Our findings from High - Performance Thin Layer Chromatography (HPTLC) analysis showed that Musa sapientum has an active compound a monomeric flavonoid (leucocyanidin) with anti-ulcerogenic activity. Results were expressed as mean ± SD. All our results are in congruous with the results of standard drug esomeprazole.Conclusion:It could be clearly concluded that administration of the aqueous extract of Musa sapientum at the dose used in this study tends to ameliorate ulcers. Its use in indigenous medicine should be scientifically scrutinized with further research.

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“…Many flavonoids and related compounds (Leucocyanidin, quercetin, and its 3-O-galactoside, 3-Oglucoside and 3-O-rhamnosyl glucoside) were isolated from the unripe pulp of plantain [35,36]. Serotonin, norepinephrine, tryptophan, indole compounds, tannin, starch, iron, crystallizable and non-crystallizable sugars, vitamin C, B-complex vitamins, fats, mineral salts were detected in the fruit pulp of M. paradisiaca var.…”

Section: Results and Discussion Phytochemicals Present In Musa Paradimentioning

confidence: 99%

ANTIULCER ACTIVITY OF Musa paradisiaca (BANANA) TEPAL AND SKIN EXTRACTS IN ULCER INDUCED ALBINO MICE

Ahmad¹

2016

MJAS

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The current use of ulcer drugs is limited due to its side effects and potentiality of relapse. This study aimed to ascertain the antiulcer potentials of the tepal and skin extracts of banana Musa paradisiaca. The parts were processed and extracted using methanol by maceration. Phytochemicals content of both parts were screened. Twenty-five albino mice were used in in vivo analysis. The mice were treated with 100 mg/kg of tepal and skin extract as well as cimetidine for seven days followed by administration of indomethacin. The animals were sacrificed, and the removed stomachs were prepared for the evaluation of ulcer index and gastric wall mucus. pH and volume were measured from the gastric juice. The results revealed that banana's tepal and skin extracts contain phytochemicals like phenols, flavonoids and etc. The tepal and skin extracts prevented the IND+PYL induced ulcer by 68.80 ± 20.53% and 43.22 ± 14.82% respectively. Significant rise (p <0.05) in gastric juice pH (3.79 ± 0.24) was noticed in the banana's tepal treated group. However, the decrease in gastric juice volume and increased gastric wall mucus by both tepal and skin were not statistically significant (p >0.05). Findings from this study shows that banana's tepal and skin were able to prevent IND+PYL induced ulcer by strengthening the gastric mucosa and decreasing the gastric juice acidity.Keywords: banana's tepal, banana's skin, indomethacin, Musa paradisiaca, preventive index Abstrak Penggunaan ubat ulser pada masa kini adalah terhad disebabkan kesan sampingan dan potensi kambuh. Kajian ini bertujuan menentukan potensi antiulser dari ekstrak jantung dan kulit pisang Musa paradisiaca. Bahagian -bahagian ini telah diproses dan diekstrak menggunakan metanol melalui kaedah rendaman. Kandungan fitokimia kedua -dua bahagian telah disaring. Dua puluh lima tikus albino telah digunakan dalam analisis in vivo. Tikus -tikus ini telah diberi rawatan dengan 100mg/kg ekstrak jantung dan kulit pisang serta simetidin selama tujuh hari di ikuti dengan rawatan dengan indomethacin. Haiwan dikorbankan selepas 8 hari rawatan, dan perut dikeluarkan bagi penilaian indeks ulser dan mukus dinding perut. pH dan jumlah jus gastrik juga diukur. Hasil kajian mendapati bahawa ekstrak jantung dan kulit pisang mengandungi beberapa fitokimia seperti fenol, flavonoid, dan lain -lain. Ekstrak jantung dan kulit ini menghalang ulser yang diaruh dengan IND+PYL masing -masing sebanyak 68.80 ± 20.53% dan 43.22 ± 14.82%. Peningkatan yang signifikan (p <0.05) pada pH jus gastrik (3.79 ± 0.24) telah diperhatikan dalam kumpulan yang dirawat dirawat dengan jantung pisang. Walau bagaimanapun, penurunan dalam jumlah jus gastrik dan meningkatkan mukus dinding perut oleh kedua -dua ekstrak adalah tidak signifikan secara statistik (p >0.05). Dapatan dari kajian ini menunjukkan bahawa jantung dan kulit pisang dapat mencegah ulser yang diaruh dengan IND+PYL melalui penambahan mukosa perut dan pengurangan keasidan jus gastrik.

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A natural flavonoid and synthetic analogues protect the gastric mucosa from aspirin-induced erosions

Cited by 45 publications

References 8 publications

Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit

Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit

Indigenous anti-ulcer activity of Musa sapientum on peptic ulcer

ANTIULCER ACTIVITY OF Musa paradisiaca (BANANA) TEPAL AND SKIN EXTRACTS IN ULCER INDUCED ALBINO MICE

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