A natural extracellular matrix hydrogel through selective nutrient restriction for hyperinflammatory starvation therapy

Chen, Pengfei; Pan, Kaifeng; Song, Nan; Yang, Yang; Gu, Chenhui; Zhong, Peiyu; Li, Lin; Li, Mobai; Zhang, Ying; Dai, Zhanqiu; Shangguan, Liqing; Lei, Chenyang; Liu, Zhaoming; Zhang, Jianfeng; Tang, Ruikang; Liu, Chao; Fan, Shunwu; Lin, Xianfeng

doi:10.1016/j.matt.2022.12.002

Cited by 5 publications

(1 citation statement)

References 86 publications

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“…Additionally, we evaluated the hydrogel's capacity to encourage angiogenesis in human umbilical vein endothelial cells (HUVECs) (Figure 3E,H). [ 20 ] The number of nodes in the GHM3 group was at least 40 times higher than in the control group, signifying a substantially improved angiogenic tendency in GHM3 hydrogels. The enhanced cell migration and exceptional angiogenic characteristics of GHM3 hydrogel in vitro can be attributed to the anti‐inflammatory capabilities of AuPt@melanin nanoparticles, which can alleviate oxidative stress‐induced barriers to angiogenesis.…”

Section: Resultsmentioning

confidence: 99%

An Immunomodulatory Hydrogel by Hyperthermia‐Assisted Self‐Cascade Glucose Depletion and ROS Scavenging for Diabetic Foot Ulcer Wound Therapeutics

Qi,

Cai,

Xiang

et al. 2023

Advanced Materials

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Current therapeutic protocols for diabetic foot ulcers (DFUs), a severe and rapidly growing chronic complication in diabetic patients, remain nonspecific. Hyperglycemia‐caused inflammation and excessive reactive oxygen species (ROS) are common obstacles encountered in DFU wound healing, often leading to impaired recovery. These two effects reinforce each other, forming an endless loop. However, adequate and inclusive methods are still lacking to target these two aspects and break the vicious cycle. This study proposes a novel approach for treating DFU wounds, utilizing an immunomodulatory hydrogel to achieve self‐cascade glucose depletion and ROS scavenging to regulate the diabetic microenvironment. Specifically, AuPt@melanin‐incorporated (GHM3) hydrogel dressing is developed to facilitate efficient hyperthermia‐enhanced local glucose depletion and ROS scavenging. Mechanistically, in vitro/vivo experiments and RNA sequencing analysis demonstrate that GHM3 disrupts the ROS‐inflammation cascade cycle and downregulates the ratio of M1/M2 macrophages, consequently improving the therapeutic outcomes for dorsal skin and DFU wounds in diabetic rats. In conclusion, this proposed approach offers a facile, safe, and highly efficient treatment modality for DFUs.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

An Immunomodulatory Hydrogel by Hyperthermia‐Assisted Self‐Cascade Glucose Depletion and ROS Scavenging for Diabetic Foot Ulcer Wound Therapeutics

Qi,

Cai,

Xiang

et al. 2023

Advanced Materials

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An Immunoregulation Hydrogel with Controlled Hyperthermia‐Augmented Oxygenation and ROS Scavenging for Treating Diabetic Foot Ulcers

Qi,

Ge,

Chen

et al. 2024

Adv Funct Materials

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Diabetic foot ulcers (DFUs), a serious and increasingly common chronic issue among diabetics, often do not respond well to generalized treatment strategies. Hypoxia and the overexpression of reactive oxygen species (ROS), resulting in inflammatory dysregulation and subsequent imbalance in macrophage phenotypes, are critical factors contributing to the prolonged non‐healing of DFU wounds. These two issues often interact in a continuous, problematic cycle. Presently, there is a lack of comprehensive strategies aimed at addressing both of these factors simultaneously to interrupt this detrimental cycle. Herein, an immunomodulatory hydrogel (PHG2) is developed for reshaping the hostile DFU microenvironment. The engineered PHG2 not only removes excess internally‐produced ROS but also generates O2, with its efficiency further boosted by local hyperthermia (42.5 °C) activated by near‐infrared light. Through both in vitro and in vivo studies, along with transcriptomic assessment, it is confirmed that PHG2 disrupts the detrimental feedback loop between ROS and inflammation while also lowering the M1/M2 macrophage ratio. Such discoveries contribute to a significant enhancement in the healing process of injuries that undergo a gradual increase in movement, covering wounds from the back, mouth, to the foot. Ultimately, this method provides an easy, safe, and highly effective solution for treating DFUs.

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Biological functions and biomedical applications of extracellular vesicles derived from blood cells

Pan,

Zhu,

Chen

et al. 2024

Free Radical Biology and Medicine

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A natural extracellular matrix hydrogel through selective nutrient restriction for hyperinflammatory starvation therapy

Cited by 5 publications

References 86 publications

An Immunomodulatory Hydrogel by Hyperthermia‐Assisted Self‐Cascade Glucose Depletion and ROS Scavenging for Diabetic Foot Ulcer Wound Therapeutics

An Immunomodulatory Hydrogel by Hyperthermia‐Assisted Self‐Cascade Glucose Depletion and ROS Scavenging for Diabetic Foot Ulcer Wound Therapeutics

An Immunoregulation Hydrogel with Controlled Hyperthermia‐Augmented Oxygenation and ROS Scavenging for Treating Diabetic Foot Ulcers

Biological functions and biomedical applications of extracellular vesicles derived from blood cells

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