A nationwide survey on the incidence and characteristics of traumatic spinal cord injury in Japan in 2018

Miyakoshi, Naohisa; Suda, Kota; Kudo, Daisuke; Sakai, Hiroaki; Nakagawa, Yukihiro; Matsumura, Yasuo; Suzuki, Shinsuke; Tokioka, Takamitsu; Tokuhiro, Akihiro; Takei, Hiroshi; Katoh, Shinsuke; Shimada, Yasuhiro

doi:10.1038/s41393-020-00533-0

Cited by 100 publications

(86 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, low fall was recorded as the leading cause of TSCI in developed countries such as Japan [3] , Italy [12] , and New Zealand [13] . Globally, automobile accidents remain the leading cause of TSCI, especially in the developing countries [14] .…”

Section: Discussionmentioning

confidence: 99%

“…(2) Government should improve medical insurance options, especially for the elderly, and rationally allocate medical resources. (3) Because many elderly persons fall at home, safety should be considered in implementing home design for the elderly [3] . (4) Improved planning should be implemented for urban-road construction, and barrier-free road and green-transportation systems should also be improved.…”

Section: Discussionmentioning

confidence: 99%

“…A systematic review published in 2014 showed that the proportion of men with spinal-cord injury is higher than that of women [16] . A survey by Fanuel et al showed that the ratio of male:female with cervical spinal cord trauma on Mount Kilimanjaro in Tanzania, Africa, is 6.5:1 [17] , while that in Japan has remained 3:1 over the past 30 years [3] . A study by Chen et al in China showed that the ratio of male:female with TSCI is 3.4:1 in the Guangdong Province [19] .…”

Section: Discussionmentioning

confidence: 99%

“…Traumatic spinal cord injury (TSCI) is increasing yearly worldwide [1] , particularly in the developing countries; the annual incidence rate in China is 23.7-60.6/million [2] . TSCI, which causes functional impairment in patients [3] , also affects these patients' families, resulting in a considerable economic societal burden [1] . The epidemiology of TSCI varies in different countries and regions.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Epidemiological Analysis of 459 Patients Hospitalized With Traumatic Spinal Cord Injury in Suzhou City, China

Niu

WeiXing

Zhang

et al. 2021

Preprint

View full text Add to dashboard Cite

Study design Retrospective study.Objective: To analyze the epidemiological characteristics of patients hospitalized with traumatic spinal cord injury (TSCI). Setting: The First Affiliated Hospital of Soochow UniversityMethods: This retrospective epidemiological study included 459 patients hospitalized with TSCI. Results: Mean age in this patient cohort was 50.7 ± 14.2 years, and 50–59 year olds were the most vulnerable age group (27.0%). Main cause of injury was fall from height in the 10-49 year-old group, traffic accident in the 50-79 year-old group, and low fall in ≥80 year-old group. Traffic accident accounted for the largest proportion of injuries (37.0%). The male-to-female ratio was 3.1:1, with more males than females accounting for all causes of injury. The difference in proportion of males to females was the greatest for fall from height and lowest for low fall. The anatomical site most vulnerable to fracture was the cervical segment (68.2%). Thoracolumbar segment (15.0%) was the anatomical site most frequently injured in fall from height, and the cervical segment was the most commonly injured site for all the remaining causes of injury. Most patients were classified with Grade D injuries using the American Spinal Injury Association (ASIA) Impairment scale. The most common complication of injuries was urinary tract infection (48.3%). Patients with bedsores had the longest hospital stay, with an average of 105 days. Patients with complications had significantly longer hospital stays than those without complications. Patients with multiple complications had longer hospital stays than those with a single complication. Patients receiving surgery accounted for 82.4%, and those receiving conservative treatment accounted for 17.6%, of our patient population. Average length of hospital stay for all patients was 51.1 ± 79.3 days. Patients that received surgery, those with ASIA Grade A, and those with injured thoracolumbar segment had prolonged hospital stays.Conclusion: Patients with TSCI were generally of advanced age. Traffic accident was the main cause of TSCI, but causes of TSCI were different in different age groups. Elderly patients showed a high rate of low fall. The majority of TSCI occurred in male patients, and males and females had different causes of TSCI. Neck injuries were relatively common. Injury sites varied according to the different causes of injury. The prolonged hospital stays of patients with TSCI were related to numerous factors. Our study highlights the need to focus on the prevention and treatment of various complications, and selection of appropriate treatment, in patients with TSCI. TSCI should be comprehensively prevented according to its epidemiological characteristics.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiological Analysis of 459 Patients Hospitalized With Traumatic Spinal Cord Injury in Suzhou City, China

Niu

WeiXing

Zhang

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…It is one of the most common severe diseases in clinic. In recent years, with the development of industry, construction, sports and transportation, the incidence of spinal cord injury is increasing (Miyakoshi et al, 2021). Spinal cord injury can be divided into two stages including primary injury and secondary injury.…”

Section: Introductionmentioning

confidence: 99%

Extraction of proanthocyanidins from grape seeds and their protective effect on spinal cord injury in rats

et al. 2022

View full text Add to dashboard Cite

Proanthocyanidins were extracted and purified from grape seeds, and the protective effect and mechanism of proanthocyanidins on spinal cord injury were explored. After extraction optimization and purification, the proanthocyanidins with purity of 92.53% were obtained. The rats were divided into control, model and treatment groups. The spinal cord injury model was established in model and treatment groups. Then, the treatment group was treated with 40 mg/kg proanthocyanidins. On the 1st, 3rd and 7th day after modeling, compared with model group, in model group the Basso-Beattie-Bresnahan scores were significantly decreased (p < 0.05). On the 7th day after modeling, compared with model group, in treatment group the spinal cord tissue superoxide dismutaseand glutathione peroxidase levels were significantly increased (p < 0.05), the malondialdehyde level was significantly decreased (p < 0.05), the necrosis factor α and interleukin 1βlevels were significantly decreased (p < 0.05), and the interleukin 10 level was significantly increased (p < 0.05). In conclusion, proanthocyanidins have protective effect on spinal cord injury in rats. The mechanisms may be related to its reducing oxidative stress and inflammation in spinal cord tissue.

show abstract

Effect of Early vs Delayed Surgical Treatment on Motor Recovery in Incomplete Cervical Spinal Cord Injury With Preexisting Cervical Stenosis

Chikuda¹,

Koyama²,

Matsubayashi³

et al. 2021

JAMA Netw Open

Self Cite

View full text Add to dashboard Cite

IMPORTANCEThe optimal management for acute traumatic cervical spinal cord injury (SCI) is unknown. OBJECTIVE To determine whether early surgical decompression results in better motor recovery than delayed surgical treatment in patients with acute traumatic incomplete cervical SCI associated with preexisting canal stenosis but without bone injury. DESIGN, SETTING, AND PARTICIPANTSThis multicenter randomized clinical trial was conducted in 43 tertiary referral centers in Japan from December 2011 through November 2019. Patients aged 20 to 79 years with motor-incomplete cervical SCI with preexisting canal stenosis (American Spinal Injury Association [ASIA] Impairment Scale C; without fracture or dislocation) were included. Data were analyzed from September to November 2020. INTERVENTIONS Patients were randomized to undergo surgical treatment within 24 hours after admission or delayed surgical treatment after at least 2 weeks of conservative treatment. MAIN OUTCOMES AND MEASURES The primary end points were improvement in the mean ASIA motor score, total score of the spinal cord independence measure, and the proportion of patients able to walk independently at 1 year after injury. RESULTS Among 72 randomized patients, 70 patients (mean [SD] age, 65.1 [9.4] years; age range, 41-79 years; 5 [7%] women and 65 [93%] men) were included in the full analysis population (37 patients assigned to early surgical treatment and 33 patients assigned to delayed surgical treatment).Of these, 56 patients (80%) had data available for at least 1 primary outcome at 1 year. There was no significant difference among primary end points for the early surgical treatment group compared with the delayed surgical treatment group (mean [SD] change in ASIA motor score, 53.7 [14.7] vs 48.5 [19.1]; difference, 5.2; 95% CI, −4.2 to 14.5; P = .27; mean [SD] SCIM total score, 77.9 [22.7] vs 71.3 [27.3]; P = .34; able to walk independently, 21 of 30 patients [70.0%] vs 16 of 26 patients [61.5%]; P = .51). A mixed-design analysis of variance revealed a significant difference in the mean change in ASIA motor scores between the groups (F 1,49 = 4.80; P = .03). The early surgical treatment group, compared with the delayed surgical treatment group, had greater motor scores than the delayed surgical treatment group at 2 weeks (mean [SD] score, 34.2 [18.8] vs 18.9 [20.9]), 3 months (mean [SD] score, 49.1 [15.1] vs 37.2 [20.9]), and 6 months (mean [SD] score, 51.5 [13.9] vs 41.3 [23.4]) after injury. Adverse events were common in both groups (eg, worsening of paralysis, 6 patients vs 6 patients; death, 3 patients vs 3 patients).

show abstract

A nationwide survey on the incidence and characteristics of traumatic spinal cord injury in Japan in 2018

Cited by 100 publications

References 22 publications

Epidemiological Analysis of 459 Patients Hospitalized With Traumatic Spinal Cord Injury in Suzhou City, China

Epidemiological Analysis of 459 Patients Hospitalized With Traumatic Spinal Cord Injury in Suzhou City, China

Extraction of proanthocyanidins from grape seeds and their protective effect on spinal cord injury in rats

Effect of Early vs Delayed Surgical Treatment on Motor Recovery in Incomplete Cervical Spinal Cord Injury With Preexisting Cervical Stenosis

Contact Info

Product

Resources

About