A nationwide population-based prospective study of cirrhosis in Iceland

Abstract

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Rolle der Hepatitis-B-Impfung in der Prävention des hepatozellulären Karzinoms

“…Neben der HBV-Infektion werden dort auch Ziele zur Bekämpfung der HCV-Infektion, wie etwa eine bessere Aufklärung oder der breitere Zugang zu Gesundheitsressourcen inklusive einer Therapie, beschrieben [ 18 ]. Eine Gruppe isländischer Autoren zeigte kürzlich, wie eine Steigerung des Alkoholkonsums sowie ein vermehrtes Auftreten von Adipositas und HCV-Infektionen in Island die früher sehr niedrige Leberzirrhoserate des Landes hat ansteigen lassen [ 17 ]. Im Umkehrschluss legen die Beobachtungen nahe, dass eine niedrige Prävalenz der genannten Faktoren zur Vermeidung von Leberzirrhosen beiträgt.…”

The importance of age for liver-related mortality in patients with metabolic-dysfunction associated steatotic liver disease

“…However, in these studies the age of the different etiologies was not particularly investigated. However, in recent prospective studies from Iceland, it was demonstrated that patients who were diagnosed with cirrhosis due to NAFLD were significantly older than patients with other etiologies ( 12 , 13 ). Interestingly, the mean age at diagnosis of alcoholic liver disease (ALD)- vs. NAFLD-cases was 58 vs. 64 years in 2010–2015 ( 12 ), and during the last 7 years [2016–2022], the mean age was 59 years in patients with ALD and 68 years in NAFLD patients ( 13 ).…”

“…However, in recent prospective studies from Iceland, it was demonstrated that patients who were diagnosed with cirrhosis due to NAFLD were significantly older than patients with other etiologies ( 12 , 13 ). Interestingly, the mean age at diagnosis of alcoholic liver disease (ALD)- vs. NAFLD-cases was 58 vs. 64 years in 2010–2015 ( 12 ), and during the last 7 years [2016–2022], the mean age was 59 years in patients with ALD and 68 years in NAFLD patients ( 13 ). Thus, it seems obvious that many of these patients will have liver-related outcomes in their 70s or 80s and the results of the current study are therefore extremely relevant.…”

Major increase in the incidence of cirrhosis in Iceland

“…1 Nýlega var birt rannsókn á nýgengi og orsökum skorpulifrar á Íslandi fyrir tímabilið 20102015. 2 Nýgengi skorpulifrar á þessu tímabili var 9,7 tilfelli fyrir hverja 100.000 íbúa. Það er þreföld aukning á nýgengi miðað fyrri rannsókn en var ennþá nokkru laegra en þekktist meðal annarra Norðurlandaþjóða.…”