A National Survey to Determine Prevalence of Trypanosoma cruzi Infection Among Pregnant Women in Ecuador

Costales, Jaime A.; Sánchez-Gómez, Amaya; Ayçaguer, Luis Carlos Silva; Cevallos, William; Tamayo, Susana; Yumiseva, César A.; Jacobson, Jerry O.; Martini, Luiggi; Carrera, Caty; Grijalva, Mario J.

doi:10.4269/ajtmh.14-0562

Cited by 8 publications

(4 citation statements)

References 20 publications

(25 reference statements)

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“…are consistent with previous estimates for age 30 and fertility rate 16 of women in Orellana Province. In 2014, 29% of the newborns in Orellana Province were delivered by women living in rural areas (Instituto Nacional de Estadísticas y Censos [INEC] data obtained at www.ecuadorencifras.gov.ec, Anuario de Estadisticas vitales-nacimientos y defunciones 2014).…”

Section: Discussionsupporting

confidence: 92%

Congenital Chagas Disease in the Ecuadorian Amazon: Maternal Screening at Delivery and Evaluation of Risk Factors Associated with Vector Exposure

Zambrano

Rouset

Carrasco³

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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Congenital infection with Trypanosoma cruzi remains a major route for Chagas disease transmission in endemic and non-endemic regions. We evaluated an intervention strategy aimed to detect congenital Chagas disease cases at a major hospital in the Ecuadorian Amazon via cord blood analysis at the time of delivery. All women giving birth at the hospital during the study period (191) were invited to participate. Among them, two (1.0%) did not adjust to the inclusion criteria and four (2.1%) declined to participate in the study, showing the intervention had good acceptability among the mothers. It was possible to obtain cord blood samples during 146 of the deliveries, and only one woman was found to be seropositive, without evidence of transmission to the newborn at delivery or 8 months later. In addition, sociodemographic and economic characterization of the study population revealed that few women had previous knowledge about Chagas disease (16.1%) whereas more than half (62.5%) recognized the vector. Recognizing the vector and having seen it indoors were associated with women from rural families, involved in agriculture, and hunting in the forest. Interestingly, most women (87.3%) reported having easy access to Ecuador's national health system, suggesting serological screening during prenatal visits would be of value in this province. With a proper prenatal screening system in place, cord blood screening would allow for timely detection of T. cruzi infection in newborns from both seropositive women and the minority (2.1%) of women who do not comply with prenatal care visits.

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Section: Discussionsupporting

confidence: 92%

Congenital Chagas Disease in the Ecuadorian Amazon: Maternal Screening at Delivery and Evaluation of Risk Factors Associated with Vector Exposure

Zambrano

Rouset

Carrasco³

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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“…Nonetheless, current data clearly indicate the existence of three major epidemiologic scenario for Chagas disease transmission in Ecuador . The western coastal region is a confirmed high‐risk region , where T. dimidiata predominates, although R. ecuadoriensis is also present. About 36% of all cases originate from this region.…”

Section: Discussionmentioning

confidence: 73%

Ten years (2004–2014) of Chagas disease surveillance and vector control in Ecuador: successes and challenges

Quinde-Calderón

Rios-Quituizaca

Solorzano

et al. 2015

Tropical Med Int Health

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Abstractobjective To describe the current situation of Chagas disease in Ecuador and to evaluate the impact of vector control for the period 2004-2014.methods Since 2004, the Ministry of Public Health has formalized activities for the surveillance and control of Chagas disease and we analyzed here available records.results More than 200 000 houses were surveyed, and 2.6% were found to be infested (95% CI: 2.6-2.7), and more than 51 000 houses were sprayed with residual insecticide, with important yearly variations. A total of 915 cases of T. cruzi infection were registered. The Amazon region is emerging as a high priority area, where nearly half of T. cruzi infection cases originate. The costal region and the southern highland valleys remain important high-risk area. Vector control efforts over the past 10 years have been effective in the coastal region, where T. dimidiata predominates, and resulted in important reductions in house infestation indices in many areas, even reaching negligible levels in some parishes.conclusion Vector efforts need to be sustained and expanded for the elimination of T. dimidiata to be feasible. Novel vector control interventions need to be designed to reduce intrusion by several triatomine species present in the Amazon region and southern Ecuador. Strong political commitment is needed to sustain current achievements and improve the national coverage of these programmes.

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“…The disease affects about 8 million people and causes about 50,000 deaths per year [ 22 , 119 ]. The disease can be transmitted perinatally; 15,000 newborns are born as infected each year [ 120 , 121 ]. The number of infected women of childbearing age is about 1 million and the risk of transmitting the parasite to the child is 3 to 5% [ 22 ].…”

Section: Different Strategies For Using Mnps and Mnps-containing Nano...mentioning

confidence: 99%

Metallic Nanoparticles and Core-Shell Nanosystems in the Treatment, Diagnosis, and Prevention of Parasitic Diseases

Król,

Fortunka,

Majchrzak

et al. 2023

Pathogens

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The usage of nanotechnology in the fight against parasitic diseases is in the early stages of development, but it brings hopes that this new field will provide a solution to target the early stages of parasitosis, compensate for the lack of vaccines for most parasitic diseases, and also provide new treatment options for diseases in which parasites show increased resistance to current drugs. The huge physicochemical diversity of nanomaterials developed so far, mainly for antibacterial and anti-cancer therapies, requires additional studies to determine their antiparasitic potential. When designing metallic nanoparticles (MeNPs) and specific nanosystems, such as complexes of MeNPs, with the shell of attached drugs, several physicochemical properties need to be considered. The most important are: size, shape, surface charge, type of surfactants that control their dispersion, and shell molecules that should assure specific molecular interaction with targeted molecules of parasites’ cells. Therefore, it can be expected that the development of antiparasitic drugs using strategies provided by nanotechnology and the use of nanomaterials for diagnostic purposes will soon provide new and effective methods of antiparasitic therapy and effective diagnostic tools that will improve the prevention and reduce the morbidity and mortality caused by these diseases.

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A National Survey to Determine Prevalence of Trypanosoma cruzi Infection Among Pregnant Women in Ecuador

Cited by 8 publications

References 20 publications

Congenital Chagas Disease in the Ecuadorian Amazon: Maternal Screening at Delivery and Evaluation of Risk Factors Associated with Vector Exposure

Congenital Chagas Disease in the Ecuadorian Amazon: Maternal Screening at Delivery and Evaluation of Risk Factors Associated with Vector Exposure

Ten years (2004–2014) of Chagas disease surveillance and vector control in Ecuador: successes and challenges

Metallic Nanoparticles and Core-Shell Nanosystems in the Treatment, Diagnosis, and Prevention of Parasitic Diseases

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