The most important aspect of management in these cases is immediate withdrawal of the suspected agent, because small pustules in a localized patch may progress to a more generalized pustular rash. 5 Treatment is supportive, and because of the self-limiting nature of the disease, no specific treatments are usually needed. However, topical or systemic corticosteroids can be used to hasten resolution. 2 We discontinued enoxaparin for our patient, and prescribed topical corticosteroid (betamethasone) cream to be used twice daily. The pustules resolved rapidly over several days.In conclusion, we present a case of a woman with a cutaneous drug reaction consistent with ALEP that occurred after enoxaparin. This case highlights enoxaparin as a novel causative agent for this type of drug reaction.