A National Survey Investigating UK Prescribers' Opinions on Chemotherapy Dosing and ‘Dose-Banding’

Kaestner, Sabine; Sewell, Graham

doi:10.1016/j.clon.2008.12.004

Cited by 14 publications

(24 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since the definition of this process in 2001 by Plumridge and Sewell [13], it has globally enabled to improve the organisation of the anticancer drugs preparation unit, through a simplification of the prescription analysis and a reduction of preparation errors [21][22][23][24][25][26][27]. Our system presents a major difference with the UK concept, where ''a range of pre-filled syringes or infusions, manufactured by pharmacy staff or purchased from commercial sources, can then be used to administer the standard dose''.…”

Section: Discussionmentioning

confidence: 99%

Dose standardisation of anticancer drugs

et al. 2011

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Dose standardisation of anticancer drugs

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Literature published on opinions of pharmacists, oncology nurses, oncologists and haematologists on dose-banding were also taken into consideration. 12,32 The questionnaire was peer-reviewed by two senior pharmacists who were not directly involved in the project. Pharmacists and registrars (senior grade of non-consultant hospital doctor) working in haematology–oncology and nurses working on the HODW in SJH were invited to participate in the survey.…”

Section: Methodsmentioning

confidence: 99%

Introduction of a dose-banding system for parenteral chemotherapy on a haematology–oncology day ward

O'Leary

Collins

Henman

et al. 2017

J Oncol Pharm Pract

View full text Add to dashboard Cite

Introduction The increasing incidence of cancer and the finite capacity of hospital aseptic compounding units pose a serious challenge to the provision of cancer care. Chemotherapy dose-banding is a method of rationalising parenteral chemotherapy dosing and supply, whereby patient-individualised doses are rounded to predetermined banded doses. The banded doses may be outsourced as stock items which increases the supply capacity of the aseptic compounding unit. Methods Kotter's 8-step change management model was used to structure the implementation of dose-banding of 5-fluorouracil 46-h infusers on the haematology-oncology day ward in St. James's Hospital, Dublin. The impact of dose-banding on local practice was assessed through pre- and post-implementation surveys of stakeholders. Results In-house surveys of pharmacy, medical and nursing staff identified a generally favourable attitude towards implementing changes in the parenteral chemotherapy supply system, with some resistance to change evident. Dose-banding of 5-fluorouracil 46-h infusers was implemented successfully on the haematology-oncology day ward. Dose rationalisation and flexibility of re-allocation of standard banded doses between patients were the primary benefits of dose-banding found. Post-implementation surveys showed that clinical staff were in favour of adopting dose-banding into standard practice; however, they were cautious about the degree to which the results of this limited study would be translated into substantive benefits if dose-banding was adopted for all suitable preparations. Conclusion The success of the implementation process and the favourable opinions of stakeholders shown in the post-implementation survey enabled the dose-banding service to be extended to a further nine drugs. Kotter's 8-step change management model was a useful tool for structuring this process change in St. James's Hospital.

show abstract

“…For each band a standard dose (mid-point of band) is provided with standard, premade syringes or infusion bags used singly or in combination to obtain a standard dose of maximum ±5% of the corresponding calculated BSA individualized dose. This concept has been proven benefits on improving workload for pharmaceutical team and nurses without measurable decrease in treatments outcomes of cancer patients [6,7]. Some widely used cytotoxic drugs have been previously dose-banded or dose-standardized [8][9][10] (i. e., carboplatin, cisplatin, paclitaxel, docetaxel, gemcitabine and monoclonal antibodies [10]).…”

Section: Introductionmentioning

confidence: 99%

Microbiological stability tests with simulated broth preparations and integrity testing for sterile standard cytotoxic preparations

Matheron

Guerault

Vazquez

et al. 2020

Pharmaceutical Technology in Hospital Pharmacy

View full text Add to dashboard Cite

ObjectivesThe objectives were to assess the microbiological stability and the physical enclosure integrity of the overwrapping for batch production of standard cytotoxic injectable solutions.MethodsBroth culture media were used in place of cytotoxic drugs to assess the worst case in term of microbiological contamination risk. Iterative sterility tests on batches were performed for 60 days using rapid microbiological method. Validation of microbiological growth of culture media was assessed by direct inoculation of <100 CFU/mL of six microbiological strains recommended by European Pharmacopeia. Validation of the ability of growth of microorganisms in 11 cytotoxic solutions and one monoclonal antibody was assessed using eight strains. In addition, the physical integrity of the seal of the overwrapping containing cytotoxic preparations was assessed by dynamometric method and dye penetration test.ResultsNo microbiological contamination was observed on all units of batches for 60 days of investigation. The ability to detect microbiological growth in cytotoxic solutions was validated for the eight challenge microorganisms after 1/10 dilution for cytotoxic investigated, except for 5 Fluorouracil, gemcitabine and cisplatin. In addition, physical integrity testing of the seal of overwrapping pointed out the need of specific validation of heatsealer and operator education.ConclusionsBesides physico-chemical testing, microbiological stability testing combined to physical integrity testing is the additional part of the development method for batch production of sterile drugs in hospital.

show abstract

A National Survey Investigating UK Prescribers' Opinions on Chemotherapy Dosing and ‘Dose-Banding’

Cited by 14 publications

References 15 publications

Dose standardisation of anticancer drugs

Dose standardisation of anticancer drugs

Introduction of a dose-banding system for parenteral chemotherapy on a haematology–oncology day ward

Microbiological stability tests with simulated broth preparations and integrity testing for sterile standard cytotoxic preparations

Contact Info

Product

Resources

About