A national study of pregnancy-related maternal and fetal outcomes in women with inflammatory bowel disease

Tarar, Zahid Ijaz; Farooq, Umer; Zafar, Muhammad Usman; Saleem, Saad; Nawaz, Ahmad; Kamal, Faisal; Ghous, Ghulam; Inayat, Faisal; Ghouri, Yezaz A.

doi:10.1007/s00384-022-04185-9

Cited by 6 publications

(1 citation statement)

References 28 publications

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“…The data appear to be quite obscure; nevertheless, the association between the body mass status and IBD is undeniable. A significant role in this area is played by adipose tissue and adipokines released by this organ [ 25 , 26 , 27 , 28 ]. Thus, we decided to perform a review of available literature on the involvement of obesity and adipose tissue in the modulation of metabolic and inflammatory background in IBD, giving special attention to their role in the treatment and general management of affected patients.…”

Section: Introductionmentioning

confidence: 99%

Impact of Obesity on the Course of Management of Inflammatory Bowel Disease—A Review

Michalak

Kasztelan-Szczerbińska

Cichoż‐Lach

2022

Nutrients

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It is already well-known that visceral adipose tissue is inseparably related to the pathogenesis, activity, and general outcome of inflammatory bowel disease (IBD). We are getting closer and closer to the molecular background of this loop, finding certain relationships between activated mesenteric tissue and inflammation within the lumen of the gastrointestinal tract. Recently, relatively new data have been uncovered, indicating a direct impact of body fat on the pattern of pharmacological treatment in the course of IBD. On the other hand, ileal and colonic types of Crohn’s disease and ulcerative colitis appear to be more diversified than it was thought in the past. However, the question arises whether at this stage we are able to translate this knowledge into the practical management of IBD patients or we are still exploring the scientific background of this pathology, having no specific tools to be used directly in patients. Our review explores IBD in the context of obesity and associated disorders, focusing on adipokines, creeping fat, and possible relationships between these disorders and the treatment of IBD patients.

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