A national common massive transfusion protocol (<scp>MTP</scp>) is a feasible and advantageous option for centralized blood services and hospitals

Chay, Jason Wai Mun; Koh, Mickey B.C.; Tan, Hwee Huang; Ng, Justin H. J.; Ng, H. J.; Chia, Naville; Kuperan, Ponnudurai; Tan, Jonathan; Lew, Eileen; Tan, Lip Kun; Koh, Pei Lin; DeSouza, Karen; Fathil, S. Bin Mohd; Kyaw, P. M.; Ang, Ai Leen

doi:10.1111/vox.12311

Cited by 18 publications

(11 citation statements)

References 58 publications

(84 reference statements)

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“…( Table 1) Seven studies included both trauma and non-trauma patients. (4-7, 9, 10, 29) The non-trauma groups in these studies were comprised of patients undergoing emergency or elective surgery (4)(5)(6)(7)(8)(9)(10)29), as well as patients with gastrointestinal bleeding(4-7, 9, 29), obstetric hemorrhage (4,5,7,10,29), and vascular emergencies (4,6,7,9,29). In three of these seven studies, analysis was performed using a mixed trauma/non-trauma population, comprising 91%(10), 76% 29 Table 4 shows the quality assessment of the studies included based on the NOS.…”

Section: A C C E P T E Dmentioning

confidence: 99%

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Massive transfusion protocols in nontrauma patients: A systematic review and meta-analysis

Sommer

Schnüriger

Candinas

et al. 2019

J Trauma Acute Care Surg

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Background Massive bleeding is a major cause of death both in trauma and non-trauma patients. In trauma patients, the implementation of massive transfusion protocols (MTP) led to improved outcomes. However, the majority of patients with massive bleeding are non-trauma patients. Objectives To assess if the implementation MTP in non-trauma patients with massive bleeding leads to improved survival. Data sources National Library of Medicine's Medline database (PubMed). Study eligibility criteria Original research articles in English language investigating MTP in non-trauma patients. Participants Non-trauma patients with massive bleeding  18 years of age. Intervention Transfusion according to MTP versus off-protocol. Study appraisal and synthesis methods Systematic literature review using PubMed. Outcomes assessed were mortality and transfused blood products. Studies that compared mortality of MTP and non-MTP groups were included in meta-analysis using Mantel-Haenszel random effect models.

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Section: A C C E P T E Dmentioning

confidence: 99%

“…10 the studies by Gutierrez and Goodnough did not include a controll group and consequently did not recieve a star in this category. In the studies by Chay (5) and Johanson(28) the number of survivors and death was not reported. These studies therefore did not receive stars for the adequacy of follow-up category.…”

Section: A C C E P T E Dmentioning

confidence: 99%

Massive transfusion protocols in nontrauma patients: A systematic review and meta-analysis

Sommer

Schnüriger

Candinas

et al. 2019

J Trauma Acute Care Surg

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“…This is a centralised systematic clinical workflow implemented by the National Blood Services Group, and blood components were transfused in a ratio of 1:1:1 (packed red blood cells: whole blood-derived platelets: fresh frozen plasma) 13. The MTP was initially created for military trauma settings, but has been extended to non-trauma general medical, surgical and obstetrics patients.…”

Section: Discussionmentioning

confidence: 99%

Management of a giant uterine leiomyoma

Lim¹,

Tan

Chia

et al. 2018

BMJ Case Reports

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Uterine leiomyomas are the most common tumours arising from the female reproductive tract. However, giant myomas, which are greater than 11.4 kg in weight, are exceedingly rare. They may cause a pressure effect on surrounding organs, heart and lungs, which can be potentially life threatening. We present a case of a 53-year-old woman with a massive uterine mass complicated by restrictive lung disease. She underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy with frozen section and reconstruction of the abdominal wall by the gynaecologists and plastic surgeons. The excised specimen weighed 27.8 kg, which included a benign subserosal leiomyoma measuring 64 by 50.5 by 15 cm. Intraoperative blood loss was 7 L and her postoperative recovery was complicated by coagulopathy and haemorrhagic shock. This case illustrates the pivotal role of multidisciplinary care in the management of complicated surgical patients and the need for careful perioperative care.

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“…Broxton and colleagues describe an evidence‐based massive transfusion checklist, but had difficulty making it work because their facility did not record MTP activations. Chay and coworkers tell of the implementation of a national 1:1:1 protocol across seven major hospitals in Singapore that improved time of blood products to the patient, but achieved actual ratios of 1:0.8:0.8. Dunbar and colleagues reviewed the wastage rates for blood components at three Level I trauma centers and found them to be high with misstorage of issued products.…”

Section: Discussionmentioning

confidence: 99%

Quality management of a massive transfusion protocol

et al. 2017

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A national common massive transfusion protocol (MTP) is a feasible and advantageous option for centralized blood services and hospitals

Abstract: This successful collaboration shows that shared transfusion protocols are feasible and potentially advantageous for hospitals sharing a central blood provider.

Cited by 18 publications

References 58 publications

Massive transfusion protocols in nontrauma patients: A systematic review and meta-analysis

Massive transfusion protocols in nontrauma patients: A systematic review and meta-analysis

Management of a giant uterine leiomyoma

Quality management of a massive transfusion protocol

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