A nascent riboswitch helix orchestrates robust transcriptional regulation through signal integration
Nils Walter,
Adrien Chauvier,
Shiba Dandpat
et al.
Abstract:Widespread manganese-sensing transcriptional riboswitches effect the dependable gene regulation needed for bacterial manganese homeostasis in changing environments. Riboswitches – like most structured RNAs – are believed to fold co-transcriptionally, subject to both ligand binding and transcription events; yet how these processes are orchestrated for robust regulation is poorly understood. Through a combination of single molecule and bulk approaches, we discovered how a single Mn2+ ion and the transcribing RNA… Show more
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