A Narrative Review Study on the Effects of Obesity and Bariatric Surgery on Multiple Sclerosis

Abstract

Obesity is a major public health concern and should be considered in autoimmune inflammatory disorders, such as multiple sclerosis (MS). In these patients, obesity leads to increasing comorbidities as well as reduced quality of life. Obesity causes an inflammatory state in the body, especially in adolescents; obesity has a role in the pathogenesis of MS. Hence, it is identified as a lifestyle modifiable risk factor for MS disease. Among various treatments for obesity, bariatric surgery has been widely used. Although few studies have been performed on bariatric surgery in MS patients, in this review, we present the existing data regarding the effects of obesity on the MS course and evaluate the outcomes of bariatric surgery among this population.

Cellular and Molecular Evidence of Multiple Sclerosis Diagnosis and Treatment Challenges

“…Obesity is increasingly prevalent worldwide, posing a severe public health problem [ 72 ]. Researchers discovered that compared to women with a normal BMI (18.5 to 21 kg/m 2 ) at age 18, those with a BMI of 30 kg/m 2 had a 2.25-fold higher chance of developing MS [ 73 ].…”

“…Researchers discovered that compared to women with a normal BMI (18.5 to 21 kg/m 2 ) at age 18, those with a BMI of 30 kg/m 2 had a 2.25-fold higher chance of developing MS [ 73 ]. Childhood obesity and female hormonal factors, or the X-chromosome, may be causing the rising female-to-male ratio in MS, as evidenced by a higher risk of MS/CIS in moderately and very obese girls but not boys [ 72 ].…”

Determination of weight loss effectiveness evaluation indexes and establishment of a nomogram for forecasting the probability of effectiveness of weight loss in bariatric surgery: a retrospective cohort

“…Obesity has emerged as a significant global health issue with considerable complications and financial burden 3 . The best approach to managing obesity is bariatric surgery, which also significantly enhances quality of life and helps patients lose weight and reduce comorbidities 4 , 5 . Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) are the two most common bariatric procedures performed worldwide 6 , 7 .…”