A narrative review of the controversy on the risk of mycobacterial infections with immune checkpoint inhibitor use: does Goldilocks have the answer?
Akshara Vaddi,
Holly J. Hulsebus,
Emily L. O’Neill
et al.
Abstract:Background and Objective
Immune checkpoint inhibitors (ICIs) have revolutionized oncologic treatment. Whether ICIs increase susceptibility to or provide protection against mycobacterial infections remains controversial. The objective of this narrative review is to summarize the literature on the link between ICI use and mycobacterial infections—tuberculosis and non-tuberculous mycobacterial (NTM) infections—and to critically discuss evidence linking ICIs with mycobacterial infections, the possible… Show more
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