A nanotherapeutic approach for fighting the odds against the malignant disorders

Saini, Samvedna; Dagar, Pranjal; Gupta, Sakshi; Kumar, Yatender

doi:10.1007/s11051-023-05754-x

Cited by 1 publication

(1 citation statement)

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“…The increment into the stimulation for a prolonged period is achieved via the release of the antigens through the depots. Thus, nanovaccines are implemented for the therapeutic and prophylactic role based on the requirements. − The nanovaccines are utilized to boost primary and secondary immune responses in the body via antigen uptake into that of the dendritic cells. This can be enhanced with the help of the particle surface ligand decorating approach for the selective recognition of dendritic cell receptors.…”

Section: Introductionmentioning

confidence: 99%

Harnessing Nanovaccines for Effective Immunization─A Special Concern on COVID-19: Facts, Fidelity, and Future Prospective

Gholap,

Gupta,

Kamandar

et al. 2023

ACS Biomater. Sci. Eng.

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Nanotechnology has emerged as a transformative pathway in vaccine research and delivery. Nanovaccines, encompassing lipid and nonlipid formulations, exhibit considerable advantages over traditional vaccine techniques, including enhanced antigen stability, heightened immunogenicity, targeted distribution, and the potential for codelivery with adjuvants or immune modulators. This review provides a comprehensive overview of the latest advancements and applications of lipid and non-lipid-based nanovaccines in current vaccination strategies for immunization. The review commences by outlining the fundamental concepts underlying lipid and nonlipid nanovaccine design before delving into the diverse components and production processes employed in their development. Subsequently, a comparative analysis of various nanocarriers is presented, elucidating their distinct physicochemical characteristics and impact on the immune response, along with preclinical and clinical studies. The discussion also highlights how nanotechnology enables the possibility of personalized and combined vaccination techniques, facilitating the creation of tailored nanovaccines to meet the individual patient needs. The ethical aspects concerning the use of nanovaccines, as well as potential safety concerns and public perception, are also addressed. The study underscores the gaps and challenges that must be overcome before adopting nanovaccines in clinical practice. This comprehensive analysis offers vital new insights into lipid and nonlipid nanovaccine status. It emphasizes the significance of continuous research, collaboration among interdisciplinary experts, and regulatory measures to fully unlock the potential of nanotechnology in enhancing immunization and ensuring a healthier, more resilient society.

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Section: Introductionmentioning

confidence: 99%