A nanotechnology based new approach for Trypanosoma evansi chemotherapy: In vitro and vivo trypanocidal effect of (-)-α-bisabolol

Baldissera, Matheus D.; Grando, Thirssa H.; Souza, Carine F.; Cossetin, Luciana F.; Silva, Ana P.T. da; Giongo, Janince L.; Monteiro, Sílvia González

doi:10.1016/j.exppara.2016.09.018

Cited by 9 publications

(2 citation statements)

References 25 publications

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“…infections. In a study comparing in vivo effects of a SLN α-bisabolol preparation using standard diminazine aceturate treatment as well as combination therapy in a T. evansi model, it was found that combination therapy with SLN preparations greatly enhanced curative effects compared with either drug taken alone [73]. Combination therapy such as eflornithine-nifurtimox therapy is currently widely used for the treatment of T. brucei infections and so this potential use of SLN to amplify the curative properties of different drugs is of particular interest [74].…”

Section: Solid Lipid Nanoparticles (Sln)mentioning

confidence: 99%

Nanoparticulate drug delivery systems for the treatment of neglected tropical protozoan diseases

Volpedo

Costa

Ryan

et al. 2019

J. Venom. Anim. Toxins incl. Trop. Dis

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Neglected Tropical Diseases (NTDs) comprise of a group of seventeen infectious conditions endemic in many developing countries. Among these diseases are three of protozoan origin, namely leishmaniasis, Chagas disease, and African trypanosomiasis, caused by the parasites Leishmania spp. , Trypanosoma cruzi , and Trypanosoma brucei respectively. These diseases have their own unique challenges which are associated with the development of effective prevention and treatment methods. Collectively, these parasitic diseases cause more deaths worldwide than all other NTDs combined. Moreover, many current therapies for these diseases are limited in their efficacy, possessing harmful or potentially fatal side effects at therapeutic doses. It is therefore imperative that new treatment strategies for these parasitic diseases are developed. Nanoparticulate drug delivery systems have emerged as a promising area of research in the therapy and prevention of NTDs. These delivery systems provide novel mechanisms for targeted drug delivery within the host, maximizing therapeutic effects while minimizing systemic side effects. Currently approved drugs may also be repackaged using these delivery systems, allowing for their potential use in NTDs of protozoan origin. Current research on these novel delivery systems has provided insight into possible indications, with evidence demonstrating their improved ability to specifically target pathogens, penetrate barriers within the host, and reduce toxicity with lower dose regimens. In this review, we will examine current research on these delivery systems, focusing on applications in the treatment of leishmaniasis, Chagas disease, and African trypanosomiasis. Nanoparticulate systems present a unique therapeutic alternative through the repositioning of existing medications and directed drug delivery.

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Section: Solid Lipid Nanoparticles (Sln)mentioning

confidence: 99%

Nanoparticulate drug delivery systems for the treatment of neglected tropical protozoan diseases

Volpedo

Costa

Ryan

et al. 2019

J. Venom. Anim. Toxins incl. Trop. Dis

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“…Recent research findings have shown new hopes for successful treatment of trypanosomosis with nanotechnology based approach. Nerolidol nanospheres have shown promising trypanocidal efficacy against diminazene aceturate resistance T. evansi infection (Baldissera et al 2016a). The association of Diminazene aceturate with α-Bisabolol and solid lipid nanoparticles containing α-Bisabolol (SLN-B) can be used as an alternative to improve the therapeutic effectiveness of D.A.…”

Section: Chemotherapymentioning

confidence: 99%

Insight into trypanosomosis (Surra) of Indian livestock: Recent updates

Singh

Maharana

2018

Indian J of Anim Sci

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Surra, caused by Trypanosoma evansi, is an economically important disease of a wide range of domestic and wild animals, and is most widely distributed. It is a potentially fatal disease causing huge economic losses to the livestock owners in terms of morbidity, mortality, abortion, infertility, reduced milk yield and also by interfering with vaccination programme in India. Due to sub clinical nature of the disease, it has been underestimated in cattle and buffaloes. Emergence of atypical cases of human trypanosomiasis has created an alarming situation and indicates a possible zoonotic threat in future. Accurate diagnosis of surra is extremely essential to identify animals for treatment, to assess the prevalence of the disease and to avoid indiscriminate usage of trypanocidal drugs. Diagnosis of surra still suffers from low sensitivity and specificity. There is an urgent need for sensitive cost effective penside diagnostic that can be applicable and affordable to smallholder farmers in endemic regions. The present review addresses various aspects of surra with special emphasis on disease epidemiology, emerging issues, current diagnostic trends, chemotherapeutics and preventive measures to limits its prevalence in livestock.

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Nanomedicines for the Treatment of Trypanosomiasis

Prayag,

Jindal

2023

Nanomedicines for the Prevention and Treatment of Infectious Diseases

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A nanotechnology based new approach for Trypanosoma evansi chemotherapy: In vitro and vivo trypanocidal effect of (-)-α-bisabolol

Cited by 9 publications

References 25 publications

Nanoparticulate drug delivery systems for the treatment of neglected tropical protozoan diseases

Nanoparticulate drug delivery systems for the treatment of neglected tropical protozoan diseases

Insight into trypanosomosis (Surra) of Indian livestock: Recent updates

Nanomedicines for the Treatment of Trypanosomiasis

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