2015
DOI: 10.1007/s10544-014-9911-z
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A nanostructured genosensor for the early diagnosis of systemic arterial hypertension

Abstract: The rapid progress of nanomedicine, especially in areas related to medical imaging and diagnostics, has motivated the development of new nanomaterials that can be combined with biological materials for specific medical applications. One such area of research involves the detection of specific DNA sequences for the early diagnosis of genetic diseases, using nanoparticles-containing genosensors. Typical genosensors devices are based on the use of sensing electrodes - biorecognition platforms - containing immobil… Show more

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Cited by 31 publications
(33 citation statements)
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“…K 3 [(Fe(CN) 6 ], K 4 Fe(CN) 6 .3H 2 O, CH 3 CH 2 OH, H 2 SO 4 , H 2 O 2 was acquired from Vetec (BRAZIL). Phosphate buffered saline solution 0.1 mol L −1 was prepared by mixing Na 2 HPO 4 , NaH 2 PO 4 and NaCl used as supporting electrolyte.…”
Section: Methodsmentioning
confidence: 99%
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“…K 3 [(Fe(CN) 6 ], K 4 Fe(CN) 6 .3H 2 O, CH 3 CH 2 OH, H 2 SO 4 , H 2 O 2 was acquired from Vetec (BRAZIL). Phosphate buffered saline solution 0.1 mol L −1 was prepared by mixing Na 2 HPO 4 , NaH 2 PO 4 and NaCl used as supporting electrolyte.…”
Section: Methodsmentioning
confidence: 99%
“…Electrochemical studies.-Electrochemical impedance (EIS) and cyclic voltammetry measurements were evaluated in order to characterize the gold electrode at each stage of functionalization. These studies were carried out on a PalmSens potentiostat (Palm Instruments BV) and Autolab PGSTAT 100, using a 10 ml of capacity cell and as supporting electrolyte 0.1 mol L −1 PBS, pH 6.5 containing a mixture of Fe(CN) 6 −4 /Fe(CN) 6 −3 5.0 mmol L −1 . A conventional three-electrode system was used with Ag/AgCl as reference electrode, platinum as counter electrode and modified gold as working electrode.…”
Section: Methodsmentioning
confidence: 99%
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“…CV and EIS measurements were subsequently carried out with [Fe(CN)6] 3-/4-] as redox couple. The charge transfer resistance (Rct) values obtained in the EIS technique can be interpreted as the interface ohmic resistance and it is commonly used to assess and characterize the layer of biomolecules adsorbed onto the electrode surface, since it express the resistance of a charge transfer between the electrode and the solution [23,24]. The Randles circuit model was used in this work, and the Rct fitted from EIS was represented as the diameter of the semicircle in the Nyquist plot.…”
Section: Immunosensig Strategymentioning
confidence: 99%