A Nanoparticle Convective Directed Assembly Process for the Fabrication of Periodic Surface Enhanced Raman Spectroscopy Substrates

Liberman, Vladimir; Yilmaz, Cihan; Bloomstein, Theodore M.; Sivasubramanian, S.; Echegoyen, Yolanda; Busnaina, Ahmed; Cann, Susan G.; Krohn, K. E.; Marchant, Michael; Rothschild, M.

doi:10.1002/adma.201001670

Cited by 99 publications

(79 citation statements)

References 37 publications

(39 reference statements)

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“…These active films should also be stable, reproducibly prepared, inexpensive, and easy to make. [22][23][24][25] In reali-…”

Section: Introductionmentioning

confidence: 99%

Peptide Mesocrystals as Templates to Create an Au Surface with Stronger Surface‐Enhanced Raman Spectroscopic Properties

Yan

et al. 2011

Chemistry A European J

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The design and fabrication of various nanostructures with predefined geometry and composition is a big challenge of nanotechnology. Here we demonstrate an Au nanoflake film replicated from a self-assembled, well-ordered, dipeptide flower-like hierarchical architecture. Such morphology can give rise to useful and remarkable surface-enhanced Raman spectroscopy (SERS) properties. We obtained these nanostructures by using a scaffold of flake-built spherical dipeptide aggregations. Gold nanoparticles were sputtered on the surface of as-assembled dipeptide by an etching system. After removing the dipeptide templates by ethanol, a metal crust was left with a morphology similar to that of the dipeptide hierarchical structure. The different steps within the process were monitored by using electron microscopy, energy-dispersive spectrum (EDS) analysis and atomic force microscopy (AFM). Cyclic voltammetry and Raman spectra were employed to prove the SERS effect of the obtained Au substrates. The enhancement factor is estimated to be about 10(4) for 4-mercaptobenzoic acid (4-MBA) molecules on the Au nanoflake surfaces.

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“…These active films should also be stable, reproducibly prepared, inexpensive, and easy to make. [22][23][24][25] In reali-…”

Section: Introductionmentioning

confidence: 99%

Peptide Mesocrystals as Templates to Create an Au Surface with Stronger Surface‐Enhanced Raman Spectroscopic Properties

Yan

et al. 2011

Chemistry A European J

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“…According to the statistical analysis, the standard deviation, σ , for all diffraction-limit pixels in the 20 µm × 20 µm area is 21.6%-22.7%, which is reasonably good compared with other random particle based SERS substrates [ 25,26 ] or hierarchical porous structures. [ 18,53 ] Although excellent variation smaller than 10% have been obtained using top-down nanofabrication methods, [54][55][56] the large area low cost fabrication and ultrabroadband response is the advantage of the proposed metasurface substrate.…”

Section: Resultsmentioning

confidence: 99%

Ultrabroadband Metasurface for Efficient Light Trapping and Localization: A Universal Surface‐Enhanced Raman Spectroscopy Substrate for “All” Excitation Wavelengths

Zhang

Liu

et al. 2015

Adv Materials Inter

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nanoporous lithography methods, [18][19][20][21] etc. However, these techniques are still expensive and complicated for the fabrication of high quality SERS substrates over large areas, thus resulting in high prices for commercial SERS substrates. Furthermore, most commercial SERS substrates can only work for individual excitation wavelengths, i.e., one particular product works at one or two excitation wavelengths only. [22][23][24][25][26][27][28] When one wants to identify anonymous trace molecules or mixed samples, multiple excitation wavelengths will be required. [29][30][31] In this case, different substrates have to be used for different wavelength excitation, which consumes more biological/chemical materials, substrates, and measurement time. This is an obvious disadvantage for conventional SERS substrates. On the contrary, the SERS EF is proportional to the product of the fi eld intensity enhancements at both excitation and Raman scattering wavelengths. It was predicted that the maximum SERS enhancement can be achieved when localized surface plasmon resonance is located between the excitation and Raman scattering wavelengths. [ 32 ] To realize higher EF, double-resonance SERS substrates were proposed to realize strong enhancements for excitation and Raman scattered signals simultaneously using expensive e-beam lithography processes. [ 23 ] Due to the narrowband absorption spectra for both resonant bands, the enhanced SERS signal is still limited within narrow spectral regions. To address this problem, broadband resonant nanostructures are highly desired. For instance, a relatively broadband 1D metal-dielectric-metal metasurface (i.e., ≈70% optical absorption from 420 to 550 nm) was fabricated using e-beam lithography to realize uniform enhancement for SERS sensing. [ 24 ] However, the top-down lithography technique imposed a signifi cant fabrication cost barrier for large-scale practical applications. In addition, 1D grating structures are polarization dependent which can only work for given polarization states (usually transverse magnetic polarization). To overcome these limitations, here we report an ultrabroadband super absorbing metasurface substrate that can enhance the SERS signal for excitation wavelengths in a broad spectral region using lithography-free processes. [ 33 ] Most frequently used excitation wavelengths for SERS (e.g., from 450 to 1100 nm [23][24][25][26][27][28]34 ] are all covered due to the broadband light trapping and fi eld concentration within deep subwavelength Most reported surface-enhanced Raman spectroscopy (SERS) substrates can work for individual excitation wavelengths only. Therefore, different substrates have to be used for different excitation wavelengths, which consumes more biological/chemical materials, substrates, and measurement time. Here, an ultrabroadband super absorbing metasurface that can work as a universal substrate for low cost and high performance SERS sensing is reported. Due to broadband light trapping and localized fi eld enhancement, this structure can...

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“…16 Although bottom-up directed assembly of NPs has been previously shown to fabricate functional and novel nanostructures, [17][18][19][20][21] current directed assembly techniques have not been able to generate solid nanostructures with nanoscale precision. This requires a fundamental understanding of the forces driving the assembly of NPs into solid nanostructures and precise control of these forces to enable the assembly of more than one type of particle.…”

Section: Dielectrophoretic Assembly Of Nanoparticlesmentioning

confidence: 99%

Novel Nanoprinting for Oral Delivery of Poorly Soluble Drugs

Yilmaz

Sarısözen

Torchilin

et al. 2016

Methodist DeBakey Cardiovascular Journal

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Many of the newly developed drugs for cancer, and some of those for cardiovascular disease, are poorly soluble in water and cannot be taken orally. This can be overcome by employing a new and effective delivery system utilizing nanotechnology. We present a new method for oral preparation of poorly soluble drugs that entails assembling (printing) drug-loaded polymeric micelles into sub-100 nm orally acceptable nanorods (NRs). Due to their small size, these NRs will have a high permeability through cells and thus should transport through the intestine to allow for drug delivery in the blood. These NRs drugs are expected to penetrate tumors more efficiently and much faster than individual nanoparticles and may also be useful for drug delivery to atherosclerotic plaque. This should lead to better bioavailability of the drug with reduced toxicity and side effects. Currently used micellar formulations are administered intravenously, which is invasive and could be toxic due to high doses and interaction with normal healthy tissues. Oral drug administration is the easiest and most desirable way to deliver most drugs, including those that are poorly soluble.MDCVJ | XII (3) 2016 158 houstonmethodist.org/debakey-journal absorption, enhance circulation time, avoid immune surveillance mechanisms, and promote delivery to the site of disease. Recent advances in nanotechnology have increased the flexibility of design and enhanced quality control of nanoparticles (NPs) such as nanotubes, NRs, nanowires, nanocages and nanodisks. Among these, NRs attract more attention due to their favorable properties over spherical particles. Ghandehari et al. demonstrated that circulation time of PEGylated NRs is higher than PEGylated gold nanospheres.12 Moreover, NRs were taken up by macrophages to a lesser extent than spherical NPs, which explains their increased circulation time and lower accumulation in the liver compared to spherical particles. Another important finding is that the serum proteins interacted strongly with spherical-shaped particles but not with NRs, which lead to less opsonization and up to 2-fold more tumor accumulation of NRs over spheres. Chauhan et al. compared PEGylated quantum-dot structures of nanospheres and NRs with equal hydrodynamic size and found that both could diffuse through 5-μm pores at the same rate. However, when the pore size decreased to the 100 nm to 400 nm range (the range of pores in tumor vasculature or the neovessels of atherosclerotic plaque), NRs diffused through the pores up to an order of magnitude faster than the nanospheres. Chauhan et al. also showed in vivo that NRs penetrated into the tumors four times as rapidly as the nanospheres. 13 More recently, Dasgupta et al. reported a systematic approach to understanding how the shape of an NP affects its cellular internalization after finding that rod-like particles assumed stable endocytotic states.14 Their summarized data suggests that rod-shaped nanotherapeutics may be far more effective for cancer therapy than currently approved sph...

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A Nanoparticle Convective Directed Assembly Process for the Fabrication of Periodic Surface Enhanced Raman Spectroscopy Substrates

Cited by 99 publications

References 37 publications

Peptide Mesocrystals as Templates to Create an Au Surface with Stronger Surface‐Enhanced Raman Spectroscopic Properties

Peptide Mesocrystals as Templates to Create an Au Surface with Stronger Surface‐Enhanced Raman Spectroscopic Properties

Ultrabroadband Metasurface for Efficient Light Trapping and Localization: A Universal Surface‐Enhanced Raman Spectroscopy Substrate for “All” Excitation Wavelengths

Novel Nanoprinting for Oral Delivery of Poorly Soluble Drugs

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