A Nanoparticle-Based Anticaries Vaccine Enhances the Persistent Immune Response To Inhibit Streptococcus mutans and Prevent Caries

Yu, You-Bo; Liu, Ying; Liang, Hangeri; Dong, Xianxin; Yang, Xiao-Yan; Li, Sha; Guo, Zhong

doi:10.1128/spectrum.04328-22

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…Thanks to nanoparticle research, pathogenic bacterial effects which often required elaborate and time-consuming methods are now rapidly being isolated by guided nanoparticle therapies involving the infusion of isolation systems with specific nanoparticles that support the selection and inspection of the exact microorganism being investigated [127]. This shows the promise of the use of nanoparticles in antimicrobial research with high numbers of cited scholarly articles related to bioactive nanoparticle research [259,80,96].…”

Section: Promising Use In Microbiology Researchmentioning

confidence: 99%

An Overview of Nanoparticle Properties and Their Bioactivity

Nwankwo,

Adewuyi,

Osho

2023

IJBcRR

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The term “nanoparticles” being expressed in microbiology is coined from the Greek word “nano” meaning “dwarf”. Nanoparticles range in size from 1-100nm. Nanoparticles vary in size, shape, and other properties and can exist with capping agents present after structure-controlled synthesis with starting materials like metals with or without organic agents. This systematic literature review article discusses current opinions on the properties of nanoparticles including the size and shape, surface area and surface charge, surface chemistry and reactivity and their magnetic properties. We also discuss the mechanisms of bioactivity of nanoparticles in reference to their interactions with microorganisms, penetration into microorganisms, disruption of cellular processes and their effects on microbial growth. We also discuss specifically, their antibacterial, antifungal and antiviral properties. This is followed by a review of their diagnostic and therapeutic applications, the factors affecting nanoparticle bioactivity (exposure time and other intrinsic physicochemical properties) and how the intrinsic properties of microorganisms such as strain selection and growth conditions are affected by the activity of nanoparticles. In this review, we also compare nanoparticle research in the new world with activities in third world countries. We conclude by discussing the toxicity and safety concerns in the use of nanoparticles including the environmental impact and regulatory guidelines in the use of nanoparticles followed by a recommendation on future guidelines for research.

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Section: Promising Use In Microbiology Researchmentioning

confidence: 99%

An Overview of Nanoparticle Properties and Their Bioactivity

Nwankwo,

Adewuyi,

Osho

2023

IJBcRR

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Section: Introductionmentioning

confidence: 99%

“…Rats are the most widely used animal for caries research 10 , 11 because of its convenience, ease of observation, and low cost. 12 To evaluate anti-caries efficacy, 11 , 13–17 most studies on anti-caries vaccines and drugs have used rat models. Similar to typical prophylactic vaccines against infectious diseases, prophylactic anti-caries vaccines should prohibit both infection by cariogenic bacteria and the development of caries.…”

Section: Introductionmentioning

confidence: 99%

An optimized caries model of Streptococcus mutans in rats and its application for evaluating prophylactic vaccines

Liu,

Li,

et al. 2024

Human Vaccines & Immunotherapeutics

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Dental caries is a prevalent oral disease that mainly results from Streptococcus mutans . Susceptibility to S. mutans decreased rapidly after weaning in a well-known rat model. However, owing to the lack of time to establish protective immunity ahead of challenge, the weaning rat model is suboptimal for assessing prophylactic vaccines against S. mutans infection. In this study, we found that, in adult rats, S. mutans cultured under air-restricted conditions showed dramatically increased colonization efficacy and accelerated development of dental caries compared with those cultured under air-unrestricted conditions. We propose that S. mutans cultured under air-restricted conditions can be used to develop an optimal caries model, especially for the evaluation of prophylactic efficacy against S. mutans . Therefore, we used the anti-caries vaccine, KFD2-rPAc, to reevaluate the protection against the challenge of S. mutans . In immunized rats, rPAc-specific protective antibodies were robustly elicited by KFD2-rPAc before the challenge. In addition to inhibiting the initial and long-term colonization of S. mutans in vivo , KFD2-rPAc immunization showed an 83% inhibitory efficacy against the development of caries, similar to that previously evaluated in a weaning rat model. These results demonstrate that culturing under air-restricted conditions can promote S. mutans infection in adult rats, thereby helping establish a rat infection model to evaluate the prophylactic efficacy of vaccines and anti-caries drugs.

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Dietary Immunoglobulin Y by Targeting Both GbpB and GtfB Enhances the Anticaries Effect in Rats

Du,

Li,

et al. 2024

International Dental Journal

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A Nanoparticle-Based Anticaries Vaccine Enhances the Persistent Immune Response To Inhibit Streptococcus mutans and Prevent Caries

Abstract: Streptococcus mutans is the main etiologic bacterium of dental caries, whose protein antigen c (PAc) has been administered as an anticaries vaccine. However, the immunogenicity of PAc is relatively weak.

Cited by 4 publications

References 32 publications

An Overview of Nanoparticle Properties and Their Bioactivity

An Overview of Nanoparticle Properties and Their Bioactivity

An optimized caries model of Streptococcus mutans in rats and its application for evaluating prophylactic vaccines

Dietary Immunoglobulin Y by Targeting Both GbpB and GtfB Enhances the Anticaries Effect in Rats

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