A nanomedicine-promising approach to provide an appropriate colon-targeted drug delivery system for 5-fluorouracil

Singh, Sima; Kotla, Niranjan G.; Tomar, Sonia; Maddiboyina, Balaji; Webster, Thomas J.; Sharma, Dinesh Kumar; Sunnapu, Omprakash

doi:10.2147/ijn.s89030

Cited by 23 publications

(12 citation statements)

References 31 publications

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“…5-Fluorouracil is a chemotherapeutic drug used in the treatment of various cancers. The delivery of this drug causes serious side effects in the body, such as mucositis, alteration in the normal microflora environment of the colon, and diarrhoea [ 51 ]. For the target-specific treatment of colon cancer, 5-fluorouracil was encapsulated within XG-poly(-vinylpyrrolidone-co-poly) (PVP)—acrylic acid-based hydrogels.…”

Section: Xg-based Systems For the Delivery Of Drugsmentioning

confidence: 99%

Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents

et al. 2023

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In the last three decades, polymers have contributed significantly to the improvement of drug delivery technologies by enabling the controlled and sustained release of therapeutic agents, versatility in designing different delivery systems, and feasibility of encapsulation of both hydrophobic and hydrophilic molecules. Both natural and synthetic polymers have been explored for the delivery of various therapeutic agents. However, due to the disadvantages of synthetic polymers, such as lack of intrinsic biocompatibility and bioactivity, hydrophobicity, and expensive and complex procedure of synthesis, there is a move toward the use of naturally occurring polymers. The biopolymers are generally derived from either plants or microorganisms and have shown a wide range of applications in drug administration due to their hydrophilic nature, biodegradability, biocompatibility, no or low toxicity, abundance, and readily available, ease of chemical modification, etc. This review describes the applications of a biopolymer, xanthan gum (XG), in the delivery of various therapeutic agents such as drugs, genetic materials, proteins, and peptides. XG is a high molecular weight, microbial heteropolysaccharide and is produced as a fermented product of Gram-negative bacteria, Xanthomonas campestris. Traditionally, it has been used as a thickener in liquid formulations and an emulsion stabiliser. XG has several favourable properties for designing various forms of drug delivery systems. Furthermore, the structure of XG can be easily modified using different temperature and pH conditions. Therefore, XG and its derivatives have been explored for various applications in the food, pharmaceutical, and cosmetic industries.

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Section: Xg-based Systems For the Delivery Of Drugsmentioning

confidence: 99%

Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents

et al. 2023

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“…Conventional chemotherapy has been effective to some degree, the key disadvantages of chemotherapy include inadequate bioavailability, large dosage criteria, harmful side effects, low therapeutic indexes, non-specific targeting and production of multiple drug resistance [93]. The positive effectiveness and negligible side effects of managed drug delivery vehicles have been preferred.…”

Section: Localized Drug Delivery Approachesmentioning

confidence: 99%

Advances in Nanomaterials-Based Carrier System for the Treatment of Breast Cancer

Mandadi

Srinivas

Prasad³

2021

JPRI

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Nanotherapeutics for the cure of breast cancer remains unswervingly succeeding and being practiced to eradicate innumerable restrictions of conventional practice obtainable for the supervision of breast cancer. Nanoparticles offer an interdisciplinary extent for exploration in imaging, diagnosis and targeting of breast cancer. Through a progressive physicochemical features and improved bioavailability, they spectacle persistent blood circulation through effective tumor targeting. Nanoparticles remain capable to diminish cytotoxic consequence of the active anticancer medications through amassed cancer cell targeting in contrast to conventional preparations. Several nanoparticles-based preparations remain in the preclinical and clinical phases of progress; amongst them, polymeric drug micelles, liposomes, and dendrimer, remain the utmost common. In this review, we have conferred the role of nanoparticles through detail to oncology, by predominantly aiming on the breast cancer and several nanodelivery systems practiced for targeting action and signaling forces through further intracellular pathways in breast cancer.

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“…Given the systemic toxicity of many chemoand immunotherapeutic drugs, probiotic bacteria have been engineered to locally deliver the treatment at the tumor site (52)(53)(54) also by exploiting the affinity of anaerobic strains for the anaerobic tumor microenvironment (55). This has the double advantage of increasing drug efficacy and reducing adverse effects (52)(53)(54). In addition, probiotics strains have also been used to deliver anticancer proteins at the tumor site in order to inhibit its growth (55).…”

Section: Probiotics As Vehicles For Drug Delivery and Gene Therapymentioning

confidence: 99%

Microbiota Manipulation by Probiotics Administration as Emerging Tool in Cancer Prevention and Therapy

2020

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A growing body of literature indicates that microbiota plays a significant role in the development and curability of cancer, essentially due to the microbial ability to modulate immune and inflammatory responses to cancer and therapeutic treatments. Probiotics consumption, either in the form of food or supplements, is an easy and feasible way to manipulate microbiota composition and a number of recent researches have shown that it may represent a valid approach to prevent cancer onset and progression, to improve the clinical efficacy of the current anticancer treatments, and to mitigate the harmful adverse events of chemo-and radiotherapy, which often lead to scale drug doses, to delay or interrupt treatments. In this review, we gather the main in vivo studies on the current topic, focusing on the beneficial effects and underlying mechanisms provided by bacterial and yeast probiotics and their combination, in the setting of various types of cancers and different therapeutic protocols. These findings will likely open the way to consider, in future, regular probiotics intake as an adjuvant strategy in cancer prevention and management.

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A nanomedicine-promising approach to provide an appropriate colon-targeted drug delivery system for 5-fluorouracil

Cited by 23 publications

References 31 publications

Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents

Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents

Advances in Nanomaterials-Based Carrier System for the Treatment of Breast Cancer

Microbiota Manipulation by Probiotics Administration as Emerging Tool in Cancer Prevention and Therapy

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