A nanocellulose-based platform towards targeted chemo-photodynamic/photothermal cancer therapy

Anh, Thu Thi; Grijalvo, Santiago; Imae, Toyoko; García-Celma, María José; Rodríguez‐Abreu, Carlos

doi:10.1016/j.carbpol.2021.118366

Cited by 35 publications

(27 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of their very high water affinity coupled with large surface-to-volume ratios, nanocelluloses form self-sustained gels with as little as 2% solid and find applications in many fields [ 6 ]. Apart from the obvious possibility of remodeling the current food packaging scenario by taking advantage of the outstanding properties of nanocelluloses [ 34 ], recent contributions demonstrate that they appear as favorable candidates for the design of hydrogels and cryogels [ 35 ], including those that exhibit electric conductive properties [ 36 ], of gas barrier [ 37 ] and membrane filtration materials [ 38 ], of supercapacitors [ 33 ], of photoremediation agents for contaminated environments [ 39 ], of oil and gas production green additives, especially in enhanced oil recovery and hydraulic fracturing applications [ 40 ], and of novel biomedical systems, as for targeted chemo-protodynamic/photothermal cancer therapy [ 41 ]. Other common applications involve nanocelluloses as paper additives, implants, dentistry aids and cosmetics, and reinforcing elements in composite materials [ 42 ].…”

Section: It All Started With Natural Polymersmentioning

confidence: 99%

Monomers and Macromolecular Materials from Renewable Resources: State of the Art and Perspectives

Gandini

Lacerda

2021

Molecules

View full text Add to dashboard Cite

A progressively increasing concern about the environmental impacts of the whole polymer industry has boosted the design of less aggressive technologies that allow for the maximum use of carbon atoms, and reduced dependence on the fossil platform. Progresses related to the former approach are mostly based on the concept of the circular economy, which aims at a thorough use of raw materials, from production to disposal. The latter, however, has been considered a priority nowadays, as short-term biological processes can efficiently provide a myriad of chemicals for the polymer industry. Polymers from renewable resources are widely established in research and technology facilities from all over the world, and a broader consolidation of such materials is expected in a near future. Herein, an up-to-date overview of the most recent and relevant contributions dedicated to the production of monomers and polymers from biomass is presented. We provide some basic issues related to the preparation of polymers from renewable resources to discuss ongoing strategies that can be used to achieve original polymers and systems thereof.

show abstract

Section: It All Started With Natural Polymersmentioning

confidence: 99%

Monomers and Macromolecular Materials from Renewable Resources: State of the Art and Perspectives

Gandini

Lacerda

2021

Molecules

View full text Add to dashboard Cite

show abstract

“…Therefore, it is reasonable to expect that the synergistic therapy of PTT and chemotherapy based on OMCN could enhance the effectiveness of ovarian cancer treatment. Besides, internal (acidic condition) and external (NIR) stimulation are beneficial to improve the drug release from carbon-based nanomaterials (including OMCN), which relies on the absorption of some aromatic drugs via simple π-stacking and the remarkable photothermal sensitivity (Yaghoubi & Ramazani, 2020 ; Do et al., 2021 ). However, no study was reported to investigate the employment of OMCN-based nanoplatform for treating ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Targeted peptide-modified oxidized mesoporous carbon nanospheres for chemo-thermo combined therapy of ovarian cancerin vitro

Wang

Liu

et al. 2022

Drug Delivery

View full text Add to dashboard Cite

Ovarian cancer remains one of serious hazards to human health due to many drawbacks of existing available treatment options. In this study, a multifunctional chemo-thermo combined therapy nanoplatform (OMCNPID) was successfully prepared, which is composed of I 6 P 8 peptide as a targeting moiety to interleukin-6 receptors (IL-6Rs), oxidized mesoporous carbon nanospheres (OMCN) as a near infrared (NIR)-triggered drug carrier and doxorubicin (DOX) as a chemotherapeutic drug and fluorescent agent. The synthesized multifunctional nanoplatform displayed high storage capacity for drugs and excellent photothermal properties. Besides, DOX was rapidly released from OMCNPID at the condition of low pH and NIR laser irradiation due to the dissociation of DOX from graphitic cores of OMCN. In vitro experimental results verified that OMCNPID could be markedly taken up by SKOV-3 monolayer cells and tumor spheroids, and revealed a remarkable synergistic chemo-photothermal effect against ovarian cancer. All the results demonstrated that OMCNPID is a pH/NIR dual-stimulus responsive nanoplatform and can achieve efficient chemo-thermo combined therapy.

show abstract

“…Functional smallmolecule grafts could easily endow CNCs with various performances, such as bioimaging, 15,16 prodrug, 23 targeted delivery, 17 and combined cancer therapy. 24 CNC-g-fluorescein isothiocyanate (FITC) and CNC-g-rhodamine B isothiocyanate (RBITC) were synthesized for tracing the cellular uptake of CNCs by introduction of epoxy groups on the hydroxyl groups of CNCs and the following reaction between the fluorescent molecules and the primary amine groups on CNCs. 15 A CNC-g-cis-aconityl-doxorubicin (CAD) prodrug system was prepared through an amidation reaction between the 6-carboxylic groups of CAD and the amino groups of aminated CNCs.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Functional polymers or small molecules are chemically conjugated onto the surface of CNCs by covalent bonds, in order to build various functional drug-delivery platforms. Functional small-molecule grafts could easily endow CNCs with various performances, such as bioimaging, , prodrug, targeted delivery, and combined cancer therapy . CNC- g -fluorescein isothiocyanate (FITC) and CNC- g -rhodamine B isothiocyanate (RBITC) were synthesized for tracing the cellular uptake of CNCs by introduction of epoxy groups on the hydroxyl groups of CNCs and the following reaction between the fluorescent molecules and the primary amine groups on CNCs .…”

Section: Introductionmentioning

confidence: 99%

“…The conjugate presented enhanced cellular binding/uptake by DBTRG-05MG, H4, and C6 cells, 1452, 975, and 46 times higher than that of non-targeted CNCs, respectively. Multifunctional CNC-based carriers were built via the conjugation of multiple small molecules, including folic acid for actively targeting tumor cells, carbon dots for both imaging and photodynamic/photothermal treatments, and doxorubicin (DOX) as an anticancer drug . However, because of a limited number of modification sites, the conjugates between CNCs and small molecules might be restricted to achieve a single function or have a lower loading capacity for drug carriers.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Copolymer-Functionalized Cellulose Nanocrystals as a pH- and NIR-Triggered Drug Carrier for Simultaneous Photothermal Therapy and Chemotherapy of Cancer Cells

Zhang

et al. 2022

Biomacromolecules

View full text Add to dashboard Cite

As a class of biocompatible and biodegradable naturally derived nanomaterials, cellulose nanocrystals (CNCs) with diverse surface functionalization have aroused considerable attention for a range of biomedical applications in drug or gene delivery, as a fluorescent nanoprobe, in cancer targeting, and in photothermal cancer therapy, among others. Herein, we construct the copolymer-functionalized CNCs as a pH-and near-infrared (NIR)-triggered drug carrier for simultaneous photothermal therapy and chemotherapy of cancer cells. Poly(ε-caprolactone)-b-poly(2-(dimethylamino)ethyl methacrylate) (PCL-b-PDMAEMA) was conjugated onto the surface of CNCs through ring-opening polymerization, followed by activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP). The resultant CNC-based drug carrier can encapsulate doxorubicin (DOX) as a therapeutic agent and indocyanine green (ICG) as an NIR dye in the PCL core and the PDMAEMA shell, respectively, via hydrophobic and electrostatic interactions. In addition to the intrinsic pH response, the release profile of DOX can also be controlled by the duration of laser irradiation due to collapse of the crystal structure of the PCL domain with the increase of temperature induced by photothermal conversion. The drug carrier can exhibit enhanced cytotoxicity toward HepG2, human hepatocyte carcinoma, cells upon laser irradiation, which can be attributed to the synergistic effect arising from NIR-triggered burst release of DOX and photothermal heating. The rod-like morphology of the CNC-based drug carrier may help accelerate the endocytosis in cell membranes compared with its common spherical counterpart. Based on the abovementioned advantages, copolymer-functionalized CNCs can serve as a promising candidate for effective cancer treatment.

show abstract

A nanocellulose-based platform towards targeted chemo-photodynamic/photothermal cancer therapy

Cited by 35 publications

References 60 publications

Monomers and Macromolecular Materials from Renewable Resources: State of the Art and Perspectives

Monomers and Macromolecular Materials from Renewable Resources: State of the Art and Perspectives

Targeted peptide-modified oxidized mesoporous carbon nanospheres for chemo-thermo combined therapy of ovarian cancerin vitro

Copolymer-Functionalized Cellulose Nanocrystals as a pH- and NIR-Triggered Drug Carrier for Simultaneous Photothermal Therapy and Chemotherapy of Cancer Cells

Contact Info

Product

Resources

About