A nano-hydroxyapatite – Pullulan/dextran polysaccharide composite macroporous material for bone tissue engineering

Fricain, Jean-Christophe; Schlaubitz, Silke; Visage, Catherine Le; Arnault, Isabelle; Derkaoui, Sidi Mohammed; Siadous, Robin; Catros, Sylvain; Lalande, Charlotte; Bareille, Reine; Renard, Martine; Fabre, Thierry; Cornet, Sandro; Durand, M.; Léonard, A.; Sahraoui, Nouredine; Letourneur, Didier; Amédée, Joëlle

doi:10.1016/j.biomaterials.2013.01.049

Cited by 204 publications

(169 citation statements)

References 42 publications

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“…In the field of periodontal tissue regeneration, the use of synthetic materials, mostly hydroxyapatites, is growing every day because of their mechanical properties very similar to human bone characteristics. So these "Miming bone materials" were studied for their ability to trigger the Guided Tissues Regeneration (GTR) mechanisms (15)(16)(17). The present study was aimed to evaluate the capability of new bio-mimetic hydroxyapatite biomaterial to treat the complex periodontal intrabony defects.…”

Section: Discussionmentioning

confidence: 99%

Pediatric patients tolerance: a comparative study about using of Er:YAG laser and self-adhesive flowable composite for treatment of primary decayed teeth

Vozza¹

2016

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SummaryAim. Hydroxyapatite (PA) has a chemical composition and physical structure very similar to natural bone and therefore it has been considered to be the ideal biomaterial able to ensure a biomimetic scaffold to use in bone tissue engineering. The aim of this study is to clinically test hydroxyapatite used as osteoconductive biomaterial in the treatment of periodontal bone defects. Clinical and radiological evaluations were conducted at 6, 12 and 18 months after the surgery. Materials and methods. Forty patients with 2-and 3-wall intrabony pockets were enrolled in this study. PPD, CAL, radiographic depth (RD) and angular defects were preoperatively measured. After surgery, patients were re-evaluated every 6 months for 18 months. Statistical analyses were also performed to investigate any differences between preoperative and postoperative measurements. Results. Paired t-test samples conducted on the data obtained at baseline and 18 months after, showed significant (p<0.01) differences in each measurement performed. The role of preoperative RD was demonstrated to be a significant key factor (p<0.01). A relevant correlation between preoperative PPD and CAL gain was also found. Conclusions.Within the limitations of this study, the absence of anatomical variables, except the morphology of the bone defect, emphasizes the importance of the proper surgical approach and the graft material used.

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Section: Discussionmentioning

confidence: 99%

Pediatric patients tolerance: a comparative study about using of Er:YAG laser and self-adhesive flowable composite for treatment of primary decayed teeth

Vozza¹

2016

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“…[ 128 ] Furthermore, recent in vivo studies also revealed the positive role of HAp incorporation in bone regeneration in defect models from small to large animals. [ 154,155 ] For instance, Liu et al demonstrated that nanofi brous hydroxyapatite/ chitosan (nHAp/CTS) scaffolds can promote bone regeneration by supporting the adhesion, proliferation, and activating integrin-BMP/Smad signaling pathway of BMSCs, when compared with the CTS group without HAp. [ 155 ] The BMSCs exhibited higher ALP activity on nHAp/CTS than CTS group.…”

Section: Progress Reportmentioning

confidence: 98%

Biopolymer/Calcium Phosphate Scaffolds for Bone Tissue Engineering

Baker

Mou

et al. 2013

Adv Healthcare Materials

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With nearly 30 years of progress, tissue engineering has shown promise in developing solutions for tissue repair and regeneration. Scaffolds, together with cells and growth factors, are key components of this development. Recently, an increasing number of studies have reported on the design and fabrication of scaffolding materials. In particular, inspired by the nature of bone, polymer/ceramic composite scaffolds have been studied extensively. The purpose of this paper is to review the recent progress of the naturally derived biopolymers and the methods applied to generate biomimetic biopolymer/calcium phosphate composites as well as their biomedical applications in bone tissue engineering.

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“…18 The existence of HAp in the polymeric matrix can accelerate the In vitro mineralization kinetics of the ECM. 19 Other evidences with respect to microstructures and nanostructures indicate that these structures increase the specific surface area of the membranes and promote interaction with growth factors and consequently trigger the induction of osteo-progenitor cells undifferentiated into the osteogenic lineage by increasing the expression of osteocalcin, a specific marker involved in bone mineralization control.…”

Section: Figure 7 Cytotoxicity Evaluation Of Phb and Phb+hap Scaffoldsmentioning

confidence: 99%

Effect of Electrospun Phb and Hap-Phb Composite Scaffolds Characteristics on Mesenchymal Stem Cell Growth Viability

Viezzer¹,

Forte²,

Berutti³

et al. 2017

MOJABB

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A nano-hydroxyapatite – Pullulan/dextran polysaccharide composite macroporous material for bone tissue engineering

Cited by 204 publications

References 42 publications

Pediatric patients tolerance: a comparative study about using of Er:YAG laser and self-adhesive flowable composite for treatment of primary decayed teeth

Pediatric patients tolerance: a comparative study about using of Er:YAG laser and self-adhesive flowable composite for treatment of primary decayed teeth

Biopolymer/Calcium Phosphate Scaffolds for Bone Tissue Engineering

Effect of Electrospun Phb and Hap-Phb Composite Scaffolds Characteristics on Mesenchymal Stem Cell Growth Viability

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