A nano-complex system to overcome antagonistic photo-chemo combination cancer therapy

Lim, Chaemin; Moon, Jihyun; Sim, Taehoon; Won, Woong Roeck; Lee, Eun Seong; Youn, Yu Seok; Oh, Kyung Taek

doi:10.1016/j.jconrel.2018.12.043

Cited by 34 publications

(20 citation statements)

References 50 publications

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“…However, the clinical application of the drug is severely limited by its severe cardiotoxicity and genotoxicity, as well as the development of MDR. 3,4 The mechanisms of tumor cell MDR are complicated, primarily including increased cellular drug efflux and antiapoptotic activity. 5 P-glycoprotein (P-gp) has an energydependent "drug pump" function through which intracellular drugs are pumped out of the cell, reducing the drug concentration inside the cells and making the cells resistant.…”

Section: Introductionmentioning

confidence: 99%

CD44-targeted hyaluronic acid–curcumin reverses chemotherapeutics resistance by inhibiting P-gp and anti-apoptotic pathways

et al. 2019

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Section: Introductionmentioning

confidence: 99%

CD44-targeted hyaluronic acid–curcumin reverses chemotherapeutics resistance by inhibiting P-gp and anti-apoptotic pathways

et al. 2019

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“…It is well known that the cellular uptake efficiency of multiple drugs in a single nanoparticle system is better than that of a mixture of several single drugs in different nanoparticle systems [25,28]; thus pointing to the importance of the physicochemical characteristics of drug carriers in combination therapy.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, in the heterogeneous and complex in vivo environment, the loading of unaggregated photosensitizers into nanoparticles is preferable for retaining the efficacy of photodynamic therapy. Previously, we developed a PEG-PLL(- g -Ce6) (Di-Ce6) as an unaggregated photosensitizer for studying photo-chemo combination therapy [25]. In this study, the Di-Ce6 was prepared as a complex with oppositely-charged liposomes.…”

Section: Resultsmentioning

confidence: 99%

“…The PEG-PLL(- g -Ce6) was synthesized by coupling PEG-PLL with activated Ce6 using DCC and NHS as previously reported by us [25]. Fluorescence images of PEG-PLL(- g -Ce6) or free Ce6 (equivalent Ce6 2 µg/mL) in PBS at different pH conditions were observed using a fluorescence-labeled organism bioimaging instrument (FOBI) fluorescence live imaging system (IFLIS; NeoScience, Suwon, South Korea).…”

Section: Methodsmentioning

confidence: 99%

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Co-delivery of D-(KLAKLAK)2 Peptide and Chlorin e6 using a Liposomal Complex for Synergistic Cancer Therapy

et al. 2019

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Nanotechnology-based photo-chemo combination therapy has been extensively investigated to improve therapeutic outcomes in anticancer treatment. Specifically, with the help of a singlet oxygen generated by the photosensitizer, the endocytosed nanoparticles are allowed to escape from the endosomal compartment, which is currently an obstacle in nanotechnology-based anticancer therapy. In this study, a liposomal complex system (Lipo (Pep, Ce6)), composed of a chlorin e6-conjugated di-block copolymer (PEG-PLL(-g-Ce6)) and a D-(KLAKLAK)2 peptide loading liposome (Lipo (Pep)), was developed and evaluated for its anticancer activity. Due to the membrane lytic ability of the D-(KLAKLAK)2 peptide and the membrane disruptive effect of the singlet oxygen generated from chlorin e6, Lipo (Pep, Ce6) accelerated the disruption of the endosomal compartment, and exhibited strong synergistic anticancer activity in vitro. The prepared liposomal complex system could potentially maximize the efficacy of the nanotechnology-based photo-chemo combination therapy, and can be regarded as a novel, versatile strategy in advanced tumor therapy.

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“…Combination therapy has been considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment [1][2][3][4]. A combination of various drugs and therapeutic modalities may synergistically inhibit cancer growth [5][6][7][8][9][10][11]. Photothermal therapy (PTT) causes cytotoxicity against malignant and diseased cells by combining a photosensitizer and a light source.…”

Section: Introductionmentioning

confidence: 99%

An On-Demand pH-Sensitive Nanocluster for Cancer Treatment by Combining Photothermal Therapy and Chemotherapy

et al. 2020

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Combination therapy is considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) system was prepared by the encapsulation of gold nanorods (AuNR) and doxorubicin (DOX) by a pH-sensitive polymer, poly(aspartic acid-graft-imidazole)-PEG, to enhance the therapeutic effect of chemotherapy and photothermal therapy. At pH 6.5, the NC systems formed aggregated structures and released higher drug amounts while sustaining a stable nano-assembly, structured with less systemic toxicity at pH 7.4. The NC could also increase antitumor efficacy as a result of improved accumulation and release of DOX from the NC system at pHex and pHen with locally applied near-infrared light. Therefore, an NC system would be a potent strategy for on-demand combination treatment to target tumors with less systemic toxicity and an improved therapeutic effect.

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A nano-complex system to overcome antagonistic photo-chemo combination cancer therapy

Cited by 34 publications

References 50 publications

CD44-targeted hyaluronic acid–curcumin reverses chemotherapeutics resistance by inhibiting P-gp and anti-apoptotic pathways

CD44-targeted hyaluronic acid–curcumin reverses chemotherapeutics resistance by inhibiting P-gp and anti-apoptotic pathways

Co-delivery of D-(KLAKLAK)2 Peptide and Chlorin e6 using a Liposomal Complex for Synergistic Cancer Therapy

An On-Demand pH-Sensitive Nanocluster for Cancer Treatment by Combining Photothermal Therapy and Chemotherapy

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