A mysterious abdominal pain during active psoriasis

Valle, Valentina; Maggioni, Marco; Carrera, Carlo Giovanni; Cattaneo, Angelo; Marzano, Angelo Valerio; Damiani, Giovanni

doi:10.1007/s11739-017-1765-y

Cited by 13 publications

(9 citation statements)

References 15 publications

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“…The most common laboratory abnormalities are leucocytosis with neutrophilia and elevated inflammatory markers, but liver test abnormalities, hypocalcemia, and hypoalbuminemia can also be present [ 6 , 14 , 15 ]. Polyarthralgias and neutrophilic cholangitis have also been described [ 16 , 17 ], as well as a high frequency of thyroid dysfunction [ 18 ]. Previous or concurrent PV was documented in approximately half of acute GPP patients [ 12 , 15 , 16 , 19 ].…”

Section: Nosological Aspectsmentioning

confidence: 99%

Pustular Psoriasis: From Pathophysiology to Treatment

Genovese

Moltrasio

Cassano³

et al. 2021

Biomedicines

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Pustular psoriasis (PP) is a clinicopathological entity encompassing different variants, i.e., acute generalized PP (GPP), PP of pregnancy (impetigo herpetiformis), annular (and circinate) PP, infantile/juvenile PP, palmoplantar PP/palmoplantar pustulosis, and acrodermatitis continua of Hallopeau (ACH), which have in common an eruption of superficial sterile pustules on an erythematous base. Unlike psoriasis vulgaris, in which a key role is played by the adaptive immune system and interleukin (IL)-17/IL-23 axis, PP seems to be characterized by an intense inflammatory response resulting from innate immunity hyperactivation, with prominent involvement of the IL-36 axis. Some nosological aspects of PP are still controversial and debated. Moreover, owing to the rarity and heterogeneity of PP forms, data on prognosis and therapeutic management are limited. Recent progresses in the identification of genetic mutations and immunological mechanisms have promoted a better understanding of PP pathogenesis and might have important consequences on diagnostic refinement and treatment. In this narrative review, current findings in the pathogenesis, classification, clinical features, and therapeutic management of PP are briefly discussed.

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Section: Nosological Aspectsmentioning

confidence: 99%

Pustular Psoriasis: From Pathophysiology to Treatment

Genovese

Moltrasio

Cassano³

et al. 2021

Biomedicines

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“…Psoriasis is a systemic chronic inflammatory disease characterized by a constellation of comorbidities, specifically some of those may also affect the digestive system. 52–55 Clinically, it appears as a scaling erythematous and infiltrated plaque, with expression of keratinocyte hyperproliferation and to a rich pabulum of inflammatory cells, comprehending T cells, plasma cells, neutrophils and macrophages. 56 The cytokine network involved in the pathogenesis of psoriasis encompasses IL-1, IL-6, IL-17, IL-19, IL-20, IL-22, TNF-α, and interferon (IFN)-stimulated secretion.…”

Section: Specific Mirna Expression Profile In Psoriasis and Possible mentioning

confidence: 99%

Dietary compounds as potential modulators of microRNA expression in psoriasis

Kocic

Damiani

Stamenković

et al. 2019

Therapeutic Advances in Chronic Disease

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Nutrigenomic DNA reprogramming in different chronic diseases and cancer has been assessed through the stimulation of gene expression and mRNA synthesis versus DNA silencing by CpG DNA modification (methylation); histone modification (acetylation, methylation) and expression of small noncoding RNAs, known as microRNAs (miRNAs). With regard to the specific nutrigenomic effects in psoriasis, the influence of specific diets on inflammatory cell signaling transcriptional factors such as nuclear factor (NF)-κB and Wnt signaling pathways, on disease-related specific cytokine expression, pro/antioxidant balance, keratinocyte proliferation/apoptosis and on proliferation/differentiation ratio have been documented; however, the influence of dietary compounds on the balance between ‘good and bad’ miRNA expression has not been considered. This review aims to summarize knowledge about aberrant microRNAs expression in psoriasis and to emphasize the potential impact of some dietary compounds on endogenous miRNA synthesis in experimental conditions in vivo and in vitro. Among the aberrantly expressed miRNAs in psoriasis, one of the most prominently upregulated seems to be miR-21. The beneficial effects of phenolic compounds (curcumin and resveratrol), vitamin D, methyl donors, and omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) are discussed. Highly expressed miR-155 has been downregulated by flavonoids (through a quercetin-rich diet) and by vitamin D. Quercetin has been effective in modulating miR-146a. On the other hand, downregulated miR-125b expression was restored by vitamin D, Coenzyme Q10 and by microelement selenium. In conclusion, the miRNA profile, together with other ‘omics’, may constitute a multifaceted approach to explore the impact of diet on psoriasis prevention and treatment.

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“…Measurement of FeNO is an easy to perform, noninvasive, reproducible test which requires relatively low collaboration. The current available data seem to suggest that the proinflammatory systemic status due to psoriasis [ 123 ] may involve also the respiratory tract [ 124 ]. From this perspective, FeNO should be a part of screening moderate-to-severe psoriasis patients.…”

Section: Discussionmentioning

confidence: 99%

Psoriasis and Respiratory Comorbidities: The Added Value of Fraction of Exhaled Nitric Oxide as a New Method to Detect, Evaluate, and Monitor Psoriatic Systemic Involvement and Therapeutic Efficacy

Santus

Rizzi

Radovanovic

et al. 2018

BioMed Research International

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Psoriasis is a chronic inflammatory systemic disease characterized by a wide range of comorbidities. Respiratory comorbidities are currently poorly characterized and with discordant results. The systemic state of inflammation caused by psoriasis acts de novo on respiratory tissues and amplifies preexisting inflammation from asthma or chronic obstructive pulmonary disease. Because the lungs act as a gas exchanger between the internal and external environment, the impact of chronic psoriasis inflammation may be easily assessed through the analysis of exhaled breath. The fraction of exhaled nitric oxide test (FeNO) is a potential noninvasive solution that can provide quantitative and qualitative indices of respiratory airway inflammation. FeNO is routinely used to screen and manage asthmatic patients. Recent pilot studies contain encouraging data that underscore its possible use with systemic inflammatory nonpulmonary diseases, such as psoriasis. FeNO may therefore be a useful tool to evaluate underestimated airway inflammation and at the same time globally evaluate the impact of systemically antipsoriatic therapies.

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A mysterious abdominal pain during active psoriasis

Cited by 13 publications

References 15 publications

Pustular Psoriasis: From Pathophysiology to Treatment

Pustular Psoriasis: From Pathophysiology to Treatment

Dietary compounds as potential modulators of microRNA expression in psoriasis

Psoriasis and Respiratory Comorbidities: The Added Value of Fraction of Exhaled Nitric Oxide as a New Method to Detect, Evaluate, and Monitor Psoriatic Systemic Involvement and Therapeutic Efficacy

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