A Myocybernetic Model of the Lower Urinary Tract

Bastiaanssen, Erica H. C.; Leeuwen, J.L. van; Vanderschoot, J.; Redert, P.A.

doi:10.1006/jtbi.1996.0011

Cited by 42 publications

(40 citation statements)

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“…This approach is similar to several other attempts to model the LUT (219, 657) but also includes putative supraspinal circuitry based on unit recordings in the PMC and PAG. The mechanical component was taken from the model produced by Bastiaanssen et al (41). The neural component was based on the electrophysiological properties of individual neuronal groups in the PMC and PAG.…”

Section: Voiding Mechanismsmentioning

confidence: 99%

Neural Control of the Lower Urinary Tract

Groat

Griffiths

Yoshimura

2014

Comprehensive Physiology

350

527

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This article summarizes anatomical, neurophysiological, pharmacological, and brain imaging studies in humans and animals that have provided insights into the neural circuitry and neurotransmitter mechanisms controlling the lower urinary tract. The functions of the lower urinary tract to store and periodically eliminate urine are regulated by a complex neural control system in the brain, spinal cord, and peripheral autonomic ganglia that coordinates the activity of smooth and striated muscles of the bladder and urethral outlet. The neural control of micturition is organized as a hierarchical system in which spinal storage mechanisms are in turn regulated by circuitry in the rostral brain stem that initiates reflex voiding. Input from the forebrain triggers voluntary voiding by modulating the brain stem circuitry. Many neural circuits controlling the lower urinary tract exhibit switch-like patterns of activity that turn on and off in an all-or-none manner. The major component of the micturition switching circuit is a spinobulbospinal parasympathetic reflex pathway that has essential connections in the periaqueductal gray and pontine micturition center. A computer model of this circuit that mimics the switching functions of the bladder and urethra at the onset of micturition is described. Micturition occurs involuntarily in infants and young children until the age of 3 to 5 years, after which it is regulated voluntarily. Diseases or injuries of the nervous system in adults can cause the re-emergence of involuntary micturition, leading to urinary incontinence. Neuroplasticity underlying these developmental and pathological changes in voiding function is discussed.

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Section: Voiding Mechanismsmentioning

confidence: 99%

Neural Control of the Lower Urinary Tract

Groat

Griffiths

Yoshimura

2014

Comprehensive Physiology

350

527

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“…where t(1, 2, …) is the discrete time index, model output ( 1,2) i Qi  and model input ( 1,2) i Pi are the observed urine flow rate value and the virtual input value respectively, parameter ( 1,2) i ai  are linked to the corresponding time constants of the associated dynamic models and parameters ( 1,2) i bi  are the gain associated with the inputs, the coordinate ( , ) rr nQ is the ridge point time index and the value. It should be explained that the model parameters have physician meanings and can be estimated from measured data.…”

Section: Figure 1 Measured Normal Urine Flow Rate Curvementioning

confidence: 99%

“…For instance, even an experienced physician may have a quarter misdiagnose in distinction between underactive and bladder outlet obstruction. To reduce such disturbances in measurement, non-invasive tests have been adopted [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…In the last two decades, there have been several noninvasive measurement based urodynamic models have been set up [1][2][3][4][5]. Started from 1989 [7,8] and formally established in 2013, a mathematical model called VBN (the initials of the first three authors) [6] has been applied to various studies, which is useful for the modelling of urodynamic function but has some intrinsic limitations, such as limited descriptions of sudden entry of the urine into the urethra and abdominal pressure.…”

Section: Introductionmentioning

confidence: 99%

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A new procedure for analysis and modelling of male urine flow rate

Gammie

Zhu

et al. 2015

2015 34th Chinese Control Conference (CCC)

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Abstract:In the first stage studies, this paper proposes a new piecewise linear discrete time dynamic model for describing global urine flow rate profiles against time sequence. The establishment of model has been guided by physician meaningful principles and measured data. To obtain the model parameters from measured data sequence, a number of existing approaches have been tailored/integrated including least squares algorithm for model time constant and gain estimation, Butterworth filter with specified cut off frequencies, for reducing noise effect induced by abdominal and bladder squeezing, then to facilitate counting the number of peaks. A few of real case studies are selected to demonstrate the effectiveness and efficiency of the proposed procedure.

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“…Cette procédure exige 5 % d'inspiration et 95 % de persévérance. De nombreux modèles de miction [1,2], souvent intéres-sants, ont été publiés à l'aboutissement d'une thèse après laquelle leurs auteurs ont changé d'orientation sans avoir eu l'occasion d'exploiter leur outil ; faute de continuité, leur travail est perdu.…”

Section: Le Modèle Comme Outil De Perfectionnement Des Connaissancesunclassified

Les modèles mathématiques de miction

Valentini

Nelson

2006

Pelv Perineol

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Après avoir rappelé ce qu'est un modèle, nous montrons que la modélisation s'impose comme méthode d'étude des systèmes ou des situations trop complexes pour que l'intuition puisse s'en saisir et que l'utilisation des mathématiques est inévitable. Sont ensuite abordés les problèmes posés par la modélisation de la miction, les différentes approches envisagées et les modèles résul-tants. Les modèles ayant été appliqués en clinique (PUMA, VBN) sont décrits ainsi que quelques-unes de leurs applications. Enfin, nous discutons l'utilité des modèles en urodynamique et décrivons les conditions permettant l'optimisation de l'usage d'un modèle. Mots clés : Modélisation -Modèle mathématique -Miction -UrodynamiqueAbstract: After a review of what constitutes a model, we show that modelling is the most effective method to study systems or phenomena too complex to be intuitively explained, and that the use of mathematical language is unavoidable. We then address the difficulties involved in modelling micturition as well as various approaches and the major results produced. Of these models, only PUMA and VBN have been applied to clinical conditions; we describe some of their applications. Finally, we discuss the usefulness of mathematical models in urodynamics and describe the conditions for optimising the use of models.

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A Myocybernetic Model of the Lower Urinary Tract

Cited by 42 publications

References 0 publications

Neural Control of the Lower Urinary Tract

Neural Control of the Lower Urinary Tract

A new procedure for analysis and modelling of male urine flow rate

Les modèles mathématiques de miction

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