A Myelin Staining Method for Old Material

Erskine, C. A.

doi:10.3109/10520294609110346

Cited by 2 publications

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“…Starting with early 20 th century studies on myelin’s importance for nerve conduction (Eveleth and Biester, 1937), followed by identification of its lipid composition (Erskine, 1946; Margolis and Pickett, 1956; Smith and Quigley, 1937) and the classic studies on its morphology from microscopy studies (Fernandez-Moran and Finean, 1957; Peters, 1960; Schmitt, 1950). The purpose of this review is to give an overview of what we currently know regarding the appearance and uniqueness of myelin in cartilaginous vertebrates.…”

Section: Introductionmentioning

confidence: 99%

Myelin in cartilaginous fish

Bellard

2016

Brain Research

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Myelin is probably one of the most fascinating and innovative biological acquisition: a glia plasma membrane tightly wrapped around an axon and insulating it. Chondrichthyans (cartilaginous fishes) form a large group of vertebrates, and they are among oldest extant jawed vertebrate lineage. It has been known from studies 150 years ago, that they are positioned at the root of the successful appearance of compact myelin and main adhesive proteins in vertebrates. More importantly, the ultrastructure of their compact myelin is indistinguishable from the one observed in tetrapods and the first true myelin basic protein (MBP) and myelin protein zero (MPZ) seem to have originated on cartilaginous fish or their ancestors, the placoderms. Thus, the study of their myelin formation would bring new insights in vertebrate’s myelin evolution. Chondrichthyans central nervous system (CNS) myelin composition is also very similar to peripheral nervous system (PNS) myelin composition. And while they lack true proteolipid protein (PLP) like tetrapods, they express a DM-like protein in their myelin.

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