A mutation in a CD44 variant of inflammatory cells enhances the mitogenic interaction of FGF with its receptor

Nedvetzki, Shlomo; Golan, Itshak; Assayag, Nathalie; Gonen, Erez; Caspi, Dan; Gladnikoff, Micha; Yayon, Avner; Naor, David

doi:10.1172/jci17100

Cited by 25 publications

(23 citation statements)

References 41 publications

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“…Theoretically, hundreds of CD44 isoforms can be generated by alternative splicing where exons are inserted in different combinations between the two constant regions of the molecule. In addition to these splice variants, posttranslational modifications by glycosylation and GAG attachments can modify the function of the CD44 isoform (25,26). Thus, it is interesting to consider potential implications of the patterns of similarities and differences in some of the splice variants observed both across tissues of the same species (dog) or between species, such as the rat, dog, and human (27).…”

Section: Interstitial Matrix Compositionmentioning

confidence: 99%

Factors Influencing the Use and Interpretation of Animal Models in the Development of Parenteral Drug Delivery Systems

Martinez

2011

AAPS J

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Abstract. Depending upon the drug and drug delivery platform, species-specific physiological differences can lead to errors in the interspecies extrapolation of drug performance. This manuscript provides an overview of the species-specific physiological variables that can influence the performance of parenteral dosage forms such as in situ forming delivery systems, nanoparticles, microspheres, liposomes, targeted delivery systems, lipophilic solutions, and aqueous suspensions. Also discussed are those factors that can influence the partitioning of therapeutic compounds into tumors, the central nervous system and the lymphatics. Understanding interspecies differences in the movement and absorption of molecules is important to the interpretation of data generated through the use of animal models when studying parenteral drug delivery.

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Section: Interstitial Matrix Compositionmentioning

confidence: 99%

Factors Influencing the Use and Interpretation of Animal Models in the Development of Parenteral Drug Delivery Systems

Martinez

2011

AAPS J

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“…Cell-free supernatants were obtained from the BM of 4 bones of chimeric NOD/SCID mice, and 50-100 μg total protein per sample were subjected to 10% SDS-PAGE followed by immunoblot with 2 μg/ml Hermes-3 anti-pan-CD44 Abs (50).…”

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MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization

et al. 2009

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“…How can even minor expression of CD44v have a substantial effect on tumor cell function? We have found (29), for example, that Namalwa cells (a B-cell lymphoma that does not express endogenous CD44), transfected with CD44v cDNA, which includes the …”

Section: Discussionmentioning

confidence: 99%

DNA vaccination with CD44 variant isoform reduces mammary tumor local growth and lung metastasis

Wallach-Dayan

Rubinstein

Hand³

et al. 2008

Molecular Cancer Therapeutics

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We have shown recently that cDNA vaccination, using a virtual lymph node, ameliorates experimental allergic encephalomyelitis. Successful cure from mammary tumor requires resolution of local tumor growth and metastases. We have examined whether targeting of CD44 cell surface adhesion molecule by cDNA vaccination plays a role in resolving mammary tumor development. We show here that CD44 cDNA vaccination decreases the tumor mass and metastatic potential in experimental mammary tumor of BALB/c mice. Vaccination of mice, inoculated with the mammary tumors, by cDNA of CD44 variant (CD44v) but not by cDNA of standard CD44, markedly reduced local tumor development and lung metastasis. Concomitantly, transfection of CD44 antisense into a highly metastatic mammary tumor cell line disrupted the CD44 expression of the cells and reduced their ability to establish local tumors as well as metastatic colonies in the lung. Moreover, when CD44v, but not standard CD44 sense cDNA, was transfected into the poorly metastatic cell line, tumor development was markedly enhanced. It is possible therefore that DNA vaccination with a specific CD44v construct could induce an immune resistance to mammary tumor progression. [Mol Cancer Ther 2008; 7(6):1615 -23]

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A mutation in a CD44 variant of inflammatory cells enhances the mitogenic interaction of FGF with its receptor

Cited by 25 publications

References 41 publications

Factors Influencing the Use and Interpretation of Animal Models in the Development of Parenteral Drug Delivery Systems

Factors Influencing the Use and Interpretation of Animal Models in the Development of Parenteral Drug Delivery Systems

MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization

DNA vaccination with CD44 variant isoform reduces mammary tumor local growth and lung metastasis

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