A Mutable Locus in Wild Populations of House Mice

Dunn, L. C.; Morgan, W. C.

doi:10.1086/281739

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…Finally, as shown recently (DUNN and MORGAN 1952), t-alleles have also been found in populations of wild mice from widely different localities. This opens up a host of problems concerning the function of this locus in the wild which we hope can be studied by us and others interested.…”

Section: Well (W S Russell 1951)supporting

confidence: 64%

Genetic Analysis of Seven Newly Discovered Mutant Alleles at Locus T in the House Mouse

Dunn

Gluecksohn-Waelsch

1953

Genetics

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N E of the eventual goals of genetical research is to elucidate the relation-0 ship between four unknown but discoverable characteristics of the genetic material. These might be listed as : 1 ) the type of change to which one genetic locus or area is subject (mutation) ; 2) the structural character of that locus or area; 3) the k i d s of developmental processes that are affected by changes in that localized material ; and 4) the role which a locus with such properties may play in adaptive responses to the environment and thereby its probability of incorporation in some future species or varietal genotype. If we were suddenly to gain an understanding of these relationships the genetical millenium would have arrived, and we should, as investigators, temporarily join the unemployed. But we know that such an event is not at hand, for precise knowledge of the relationship between these primary attributes is not likely to develop from the study of any one species or any single line of attack. The goal is too distant a one to give us the practical directions we need in charting our way among the detailed technical studies which form the indbpensable raw material for synthesis. Yet if we bear in mind what the end is, we shall at least be influenced in our choice of means, and choose to follow up, in the more modest ways in which experimental studies must be circumscribed, those problems and materials which offer some hope of making progress in these four problems, which show signs even now of having a single direction.It is probably some such thoughts which have encouraged us to persist over a period of yearsin the study of material which many people consider refractory and, slow but which to us presents fascinating immedliate problems and almost daily surprises on the way toward a more ambitious and distant goal. The house mouse, as bred in captivity for hundreds of years, is as everyone knows, good for breeding experiments. Four or five generations a year, if not equal to the daily or bimonthly generation period of other useful animals and

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Section: Well (W S Russell 1951)supporting

confidence: 64%

Genetic Analysis of Seven Newly Discovered Mutant Alleles at Locus T in the House Mouse

Dunn

Gluecksohn-Waelsch

1953

Genetics

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“…The study of biochemical variants led to increasing interest not only in inbred strains but also in wild mice. DUNN (DUNN and MORGAN 1952) had first used wild mice to search for new forms of the t-complex. He indeed found a range of different t-haplotypes and concluded that they are maintained as polymorphisms in the wild as a result of their abnormally high transmission from heterozygous males (DUNN and MORGAN 1952;DUNN 1957DUNN , 1964.…”

mentioning

confidence: 99%

“…DUNN (DUNN and MORGAN 1952) had first used wild mice to search for new forms of the t-complex. He indeed found a range of different t-haplotypes and concluded that they are maintained as polymorphisms in the wild as a result of their abnormally high transmission from heterozygous males (DUNN and MORGAN 1952;DUNN 1957DUNN , 1964. Wild mice were then found to provide a rich source of biochemical genetic variation (CHAPMAN 1978) and numerous inbred strains were developed from various subspecies and species (BONHOMME and GU~NET 1989).…”

mentioning

confidence: 99%