A mussel-inspired carboxymethyl cellulose hydrogel with enhanced adhesiveness through enzymatic crosslinking

Zhong, Yujie; Wang, Jie; Yuan, Zhenyu; Wang, Yu; Xi, Zhenhao; Li, Li; Li, Yong; Guo, Xuhong

doi:10.1016/j.colsurfb.2019.03.044

Cited by 83 publications

(29 citation statements)

References 39 publications

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“…CMC-based hydrogels have gained much interest in this context mainly due to their excellent capability of maintaining the moist environment around the targeted wound area that accelerates the cell growth, facilitates the functioning of enzymes and hormones, and overall, enhances the cell growth factors significantly [269,270]. Additionally, they promote the proliferation and migration of various keratinocytes and fibroblasts that reduce the wound healing time and decrease the formation of scars [271][272][273]. A few years ago, Capanema et al (2017) [271] developed a poly-(ethylene glycol) modified CMC-based hydrogel with flexible swelling behavior and excellent mechanical properties.…”

Section: Tissue Engineering Wound Dressingmentioning

confidence: 99%

Recent Developments of Carboxymethyl Cellulose

et al. 2021

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Carboxymethyl cellulose (CMC) is one of the most promising cellulose derivatives. Due to its characteristic surface properties, mechanical strength, tunable hydrophilicity, viscous properties, availability and abundance of raw materials, low-cost synthesis process, and likewise many contrasting aspects, it is now widely used in various advanced application fields, for example, food, paper, textile, and pharmaceutical industries, biomedical engineering, wastewater treatment, energy production, and storage energy production, and storage and so on. Many research articles have been reported on CMC, depending on their sources and application fields. Thus, a comprehensive and well-organized review is in great demand that can provide an up-to-date and in-depth review on CMC. Herein, this review aims to provide compact information of the synthesis to the advanced applications of this material in various fields. Finally, this article covers the insights of future CMC research that could guide researchers working in this prominent field.

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Section: Tissue Engineering Wound Dressingmentioning

confidence: 99%

Recent Developments of Carboxymethyl Cellulose

et al. 2021

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“…Aiming at preparing mussel-inspired adhesive hydrogels for wound closure applications, Zhong et al [ 45 ] prepared novel CMC-based constructs amenable to in situ enzymatic crosslinking. Following EDC/NHS-catalysed CMC functionalisation with catechol moieties, CMC-DA hydrogels were fabricated via horseradish peroxidase (HRP)-mediated crosslinking in the presence of hydrogen peroxide (H 2 O 2 ).…”

Section: Resultsmentioning

confidence: 99%

Mussel-Inspired Catechol Functionalisation as a Strategy to Enhance Biomaterial Adhesion: A Systematic Review

et al. 2021

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Biomaterials have long been explored in regenerative medicine strategies for the repair or replacement of damaged organs and tissues, due to their biocompatibility, versatile physicochemical properties and tuneable mechanical cues capable of matching those of native tissues. However, poor adhesion under wet conditions (such as those found in tissues) has thus far limited their wider application. Indeed, despite its favourable physicochemical properties, facile gelation and biocompatibility, gellan gum (GG)-based hydrogels lack the tissue adhesiveness required for effective clinical use. Aiming at assessing whether substitution of GG by dopamine (DA) could be a suitable approach to overcome this problem, database searches were conducted on PubMed® and Embase® up to 2 March 2021, for studies using biomaterials covalently modified with a catechol-containing substituent conferring improved adhesion properties. In this regard, a total of 47 reports (out of 700 manuscripts, ~6.7%) were found to comply with the search/selection criteria, the majority of which (34/47, ~72%) were describing the modification of natural polymers, such as chitosan (11/47, ~23%) and hyaluronic acid (6/47, ~13%); conjugation of dopamine (as catechol “donor”) via carbodiimide coupling chemistry was also predominant. Importantly, modification with DA did not impact the biocompatibility and mechanical properties of the biomaterials and resulting hydrogels. Overall, there is ample evidence in the literature that the bioinspired substitution of polymers of natural and synthetic origin by DA or other catechol moieties greatly improves adhesion to biological tissues (and other inorganic surfaces).

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“…It is good in viscosity building, flocculation and high shear stability. Normally, CMC is available, easily purchased and it has low price compared to other polysaccharides [11], [12]. There have previous study that CMC improved in mechanical strength and biocompatibility of scaffold structure.…”

Section: Mechanical Properties Analysis Of Scaffold Materials Using Nomentioning

confidence: 99%

Mechanical Properties Analysis of Scaffold Material Using Nonlinear Least Squares Fitting by Hyperelastic Model

Wiwatwongwana¹,

Promma²

2020

IJMMM

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Nowadays, the number of chronic wounds is on the rise. Wounds can caused by many problems such as disease, burn, ulceration, trauma and accident. Tissue engineering aims to produce porous scaffold biomaterials to regenerate damaged tissues to growth of new tissue. This research, gelatin was blended with Carboxymethylcellulose (CMC) in various conditions and fabricated to porous structure by using freezedrying method. All scaffolds were strengthen their structure by dehydrothermal crosslinking. Normally, the scaffold behavior is likely to be a foam-like hyperelastic material. Therefore, this research was selected Blatz-Ko model to describe the material behavior that acts as a foam rubber. This model could apply with both cases of compressible and incompressible material. The mechanical characterization of the scaffold was investigated by compressive test using universal testing machine (UTM). The experimental data obtained from the UTM was used to plot the stress-strain curve. The initial shear modulus of the material was identified by function derived from Blatz-Ko hyperelastic model using non-linear curve fitting method. The result revealed that Blatz-Ko model could fit curve at approximately 7% strain which was suitable for infinitesimal strain theory. The dehydrothermal treated scaffold with 90:10 gelatin/CMC ratio showed the highest shear modulus of 10.47±1.21 kPa. The structural collapse occurred in 60:40 gelatin/CMC scaffold. The physical characterization was done by using scanning electron microscopy (SEM) to investigate surface morphology and pore size of scaffolds. The results showed the appropriate pore size of the scaffold with average pore size of 117 µm to 197 µm. The 90:10 gelatin/CMC scaffold showed the biggest pore size.

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A mussel-inspired carboxymethyl cellulose hydrogel with enhanced adhesiveness through enzymatic crosslinking

Cited by 83 publications

References 39 publications

Recent Developments of Carboxymethyl Cellulose

Recent Developments of Carboxymethyl Cellulose

Mussel-Inspired Catechol Functionalisation as a Strategy to Enhance Biomaterial Adhesion: A Systematic Review

Mechanical Properties Analysis of Scaffold Material Using Nonlinear Least Squares Fitting by Hyperelastic Model

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