A mussel glue-inspired monomer-etchant cocktail for improving dentine bonding

Mussel-inspired polymer with catechol and cationic Lys functionalities for dentin wet bonding

“…To address the disadvantages of the presence of water on dentin adhesion, researchers have proposed a few mussel-inspired catechol-containing polymers for use in dentin bonding that showed promising results [ [30] , [31] , [32] , 34 ]. However, these simplified polymers failed to capture the complex synergy between amino acids and catechol in natural Mfps.…”

“…To evaluate the binding affinity of CLM to dentin collagen, molecular docking was performed using Molecular Operating Environment (Chemical Computing Group, Montreal, QC, Canada) [ 34 , 42 ]. Three crystal structures of type I collagen were selected from the Protein Data Bank database (IDs: 4OY5, 1CGD, and 1QSU).…”

“…A weight of 10 was used for tethering sidechain atoms to their original positions. All docked conformations were ranked by London dG scoring, followed by force field refinement on the top 30 poses and rescoring based on the GBVI/WSA dG bonding free-energy scoring method [ 34 ].…”

“…These catecholic proteins play a vital role in mussel bonding as the catechol moiety can form various chemical bonds with the substrate, including hydrogen bonds, Michael additions, cation–π interactions, and π–π coupling [ [23] , [24] , [25] , [26] , [27] , [28] ]. Accordingly, recombined mussel adhesive protein and catechol-functionalized polymers have been used as primers or etchant additives in dentin wet bonding [ [29] , [30] , [31] , [32] , [33] , [34] ]. According to previous studies, these highly active monomers can improve the types of chemical bonding forces and reduce collagen degradation at the bonding interface, thereby improving the durability of dentin bonding [ [29] , [30] , [31] , [32] , [33] , [34] ].…”

“…Accordingly, recombined mussel adhesive protein and catechol-functionalized polymers have been used as primers or etchant additives in dentin wet bonding [ [29] , [30] , [31] , [32] , [33] , [34] ]. According to previous studies, these highly active monomers can improve the types of chemical bonding forces and reduce collagen degradation at the bonding interface, thereby improving the durability of dentin bonding [ [29] , [30] , [31] , [32] , [33] , [34] ]. However, these previous studies did not involve in-depth research on the dynamic bonding process involved in water contamination.…”