A Museum of Stem Cells Points to Muse Cells as Robust Transplantable Cells for Stroke: Review

Park, You Jeong; Farooq, Jeffrey; Cho, Justin; Cozene, Blaise; Gonzales-Portillo, Bella; Sadanandan, Nadia; Saft, Madeline; Lee, Jea Young; Borlongan, Cesar V.

doi:10.1007/5584_2020_596

Cited by 3 publications

(1 citation statement)

References 67 publications

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“…3 Therefore, Muse cells do not undergo tumorigenesis when transplanted into a host organism, are the most promising cells in regenerative fields. 18 Another unique characteristic of Muse cells is their unique immune privilege system. 19…”

Section: Pluripotent and Non-tumorigenesismentioning

confidence: 99%

Application prospects of multilineage differentiating stress-enduring (Muse) cells in the treatment of skin diseases

Mao¹,

Zhang²,

Jin³

2022

JDC

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Multilineage differentiating stress-enduring (Muse) cells are a subgroup of mesenchymal stem cells (MSCs) that express stage-specific embryonic antigen-3 (SSEA-3) and CD105. It is capable of generating cells representing all three germ layers from a single cell and is non-tumorigenic. Muse cells can efficiently migrate and integrate into damaged tissues that produce sphingosine-1-phosphate (S1P), while Muse cells specifically express S1P receptor 2. The factors secreted by Muse cells play anti-inflammatory, anti-fibrosis, and anti-apoptotic effects, and cooperate to complete the function and structure repair of the damaged group. This review summarizes the basic characteristics of Muse cells and describes their application in skin repair.

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Section: Pluripotent and Non-tumorigenesismentioning

confidence: 99%

Application prospects of multilineage differentiating stress-enduring (Muse) cells in the treatment of skin diseases

Mao¹,

Zhang²,

Jin³

2022

JDC

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The Phoenix of stem cells: pluripotent cells in adult tissues and peripheral blood

Cancedda,

Mastrogiacomo

2024

Front. Bioeng. Biotechnol.

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Pluripotent stem cells are defined as cells that can generate cells of lineages from all three germ layers, ectoderm, mesoderm, and endoderm. On the contrary, unipotent and multipotent stem cells develop into one or more cell types respectively, but their differentiation is limited to the cells present in the tissue of origin or, at most, from the same germ layer. Multipotent and unipotent stem cells have been isolated from a variety of adult tissues, Instead, the presence in adult tissues of pluripotent stem cells is a very debated issue. In the early embryos, all cells are pluripotent. In mammalians, after birth, pluripotent cells are maintained in the bone-marrow and possibly in gonads. In fact, pluripotent cells were isolated from marrow aspirates and cord blood and from cultured bone-marrow stromal cells (MSCs). Only in few cases, pluripotent cells were isolated from other tissues. In addition to have the potential to differentiate toward lineages derived from all three germ layers, the isolated pluripotent cells shared other properties, including the expression of cell surface stage specific embryonic antigen (SSEA) and of transcription factors active in the early embryos, but they were variously described and named. However, it is likely that they are part of the same cell population and that observed diversities were the results of different isolation and expansion strategies. Adult pluripotent stem cells are quiescent and self-renew at very low rate. They are maintained in that state under the influence of the “niche” inside which they are located. Any tissue damage causes the release in the blood of inflammatory cytokines and molecules that activate the stem cells and their mobilization and homing in the injured tissue. The inflammatory response could also determine the dedifferentiation of mature cells and their reversion to a progenitor stage and at the same time stimulate the progenitors to proliferate and differentiate to replace the damaged cells. In this review we rate articles reporting isolation and characterization of tissue resident pluripotent cells. In the attempt to reconcile observations made by different authors, we propose a unifying picture that could represent a starting point for future experiments.

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Quite amusing stem cells: Muse cells

Borlongan¹,

Monsour²

2023

Neural Regeneration Research

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A Museum of Stem Cells Points to Muse Cells as Robust Transplantable Cells for Stroke: Review

Cited by 3 publications

References 67 publications

Application prospects of multilineage differentiating stress-enduring (Muse) cells in the treatment of skin diseases

Application prospects of multilineage differentiating stress-enduring (Muse) cells in the treatment of skin diseases

The Phoenix of stem cells: pluripotent cells in adult tissues and peripheral blood

Quite amusing stem cells: Muse cells

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