A murine model to evaluate immunotherapy effectiveness for human Fanconi anemia-mutated acute myeloid leukemia
Tingting Huang,
Bernice Leung,
Yuyang Huang
et al.
Abstract:Fanconi anemia (FA)-mutated acute myeloid leukemia (AML) is a secondary AML with very poor prognosis and limited therapeutic options due to increased sensitivity to DNA-damaging agents. PD-1 immune checkpoint inhibitors upregulate T-cell killing of cancer cells and is a class of promising treatment for FA-AML. Here, we developed a novel FA-AML murine model that allows the study of human AML with a humanized immune system in order to investigate immunotherapeutic treatments in vivo. FA-AML1 cells and non-FA-mut… Show more
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