A Murine Model of Lyme Disease Demonstrates That<i>Borrelia burgdorferi</i>Colonizes the Dura Mater and Induces Inflammation in the Central Nervous System

Casselli, Timothy; Divan, Ali; Tourand, Yvonne; Pecoraro, Heidi L.; Brissette, Catherine A.

doi:10.1101/2020.04.24.060681

Cited by 2 publications

(1 citation statement)

References 77 publications

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“…These results indicate that the Dbps (and the lysine residues) most likely have a role in the pathogenesis of neuroborreliosis. Of note, Lyme borreliae have been shown to infect the dura mater of mice where decorin is highly expressed (Casselli et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Conserved lysine residues in decorin binding proteins ofBorrelia gariniiare critical in adhesion to human brain microvascular endothelial cells

Pietikäinen

Åstrand

Cuellar

et al. 2021

Molecular Microbiology

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Lyme borreliosis is a tick‐borne disease caused by Borrelia burgdorferi sensu lato spirochetes (Lyme borreliae). When the disease affects the central nervous system, it is referred to as neuroborreliosis. In Europe, neuroborreliosis is most often caused by Borrelia garinii. Although it is known that in the host Lyme borreliae spread from the tick bite site to distant tissues via the blood vasculature, the adherence of Lyme borreliae to human brain microvascular endothelial cells has not been studied before. Decorin binding proteins are adhesins expressed on Lyme borreliae. They mediate the adhesion of Lyme borreliae to decorin and biglycan, and the lysine residues located in the binding site of decorin binding proteins are important to the binding activity. In this study, we show that lysine residues located in the canonical binding site can also be found in decorin binding proteins of Borrelia garinii, and that these lysines contribute to biglycan and decorin binding. Most importantly, we show that the lysine residues are crucial for the binding of Lyme borreliae to decorin and biglycan expressing human brain microvascular endothelial cells, which in turn suggests that they are involved in the pathogenesis of neuroborreliosis.

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Section: Discussionmentioning

confidence: 99%

Conserved lysine residues in decorin binding proteins ofBorrelia gariniiare critical in adhesion to human brain microvascular endothelial cells

Pietikäinen

Åstrand

Cuellar

et al. 2021

Molecular Microbiology

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The History of the Discovery and Research of Lyme Borreliosis in Animals and Humans

SOROKA¹,

Kravchuk²,

ZHURENKO³

2022

Ukrainian journal of veterinary sciences

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The relevance of this study is conditioned upon the substantial importance of the history of the discovery and research of Lyme borreliosis for medical science and veterinary medicine, since new theories, experiments, conclusions are built on the research of scientists who have proved the existence of this disease in animals and humans, and positive practices are accumulated regarding methods and schemes of treatment and prevention. The purpose of this study was to analyse the literature primary sources covering the history of the discovery, the results of the study of Lyme borreliosis disease to understand the features of its course and search for effective diagnostic and treatment methods. The chronology of the main results confirming the existence of Lyme borreliosis caused by Ixodidae ticks is summarised. Scientific sources covering the history of the discovery and research of Lyme borreliosis were analysed to understand the features of its course and search for effective methods of laboratory diagnostics and treatment. The main projects of the European Union programme aimed at financing research and innovative development “Horizon 2020” were determined. It was found that the projects in the field of Lyme borreliosis research also relate to certain topics, namely the creation of tests for the detection of Lyme disease, the study of the vectors of the causative agents of this disease, the development of an appropriate vaccine, and the assessment of the risks of consequences for human and animal health. It was concluded that the main areas of research are as follows: persistence of diseases and their causative agents transmitted by Ixodidae ticks; natural control of Ixodidae ticks; detection of pathogens in Ixodidae ticks; level of infection of vertebrates; habitats and natural foci of vectors and their hosts; testing and medical trials; effect of magnetic field on Borrelia; genome mapping of Borrelia species, visualisation of the human brain for disease research; research by polymerase chain reaction; endocrine studies; immune complexes, diagnosis of neuropsychiatric complications in children and adults. The practical value of this study lies in the awareness of modern scientists about the chronology of the study of Lyme borreliosis, the main ways of distribution and methods of its diagnosis in animals and humans, determining the prospects for further research according to the topical issues covered in this paper, which are solved within the framework of international projects

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A Murine Model of Lyme Disease Demonstrates ThatBorrelia burgdorferiColonizes the Dura Mater and Induces Inflammation in the Central Nervous System

Cited by 2 publications

References 77 publications

Conserved lysine residues in decorin binding proteins ofBorrelia gariniiare critical in adhesion to human brain microvascular endothelial cells

Conserved lysine residues in decorin binding proteins ofBorrelia gariniiare critical in adhesion to human brain microvascular endothelial cells

The History of the Discovery and Research of Lyme Borreliosis in Animals and Humans

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