Abstract:NK and T cells play a pivotal role in host defense to Cryptococcus neoformans (C. neoformans) fungus which affects especially hosts with impaired cell mediated immunity. The vaccine against cryptococcosus is not developed yet, thus we established an animal BALB/c mice model to analyze anticryprococcal activity of immune cells. We detected that non-stimulated spleen mononuclear cells (MNC) from non-immunized mice have the capacity to exhibit anticriptococcal activity on the incapsulated C. neoformans stra… Show more
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