A Multivariate Twin Study of Obsessive-Compulsive Symptom Dimensions

Iervolino, Alessandra C.; Rijsdijk, Frühling; Cherkas, Lynn; Fullana, Miquel À.; Mataix‐Cols, David

doi:10.1001/archgenpsychiatry.2011.54

Cited by 114 publications

(127 citation statements)

References 41 publications

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“…It must be noted that age at onset was ascertained retrospectively, and therefore the negative findings must be interpreted in light of this limitation. Although topologically not converging with previous findings (e.g., references 8, 9), the results of the symptom dimension analyses broadly agree with the notion that the various subphenotypes of OCD have overlapping but also unique neural correlates (41), which may in turn reflect genetic and especially environmental influences on each of these phenotypes (42).…”

Section: Association With Clinical Characteristicssupporting

confidence: 70%

Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder

Wit

Alonso

Schweren

et al. 2015

FOC

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Objective: Results from structural neuroimaging studies of obsessive-compulsive disorder (OCD) have been only partially consistent. The authors sought to assess regional gray and white matter volume differences between large samples of OCD patients and healthy comparison subjects and their relation with demographic and clinical variables.Method: A multicenter voxel-based morphometry mega-analysis was performed on 1.5-T structural T 1 -weighted MRI scans derived from the International OCD Brain Imaging Consortium. Regional gray and white matter brain volumes were compared between 412 adult OCD patients and 368 healthy subjects.

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Section: Association With Clinical Characteristicssupporting

confidence: 70%

Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder

Wit

Alonso

Schweren

et al. 2015

FOC

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“…One important challenge will be the known etiological heterogeneity within each of these disorders. 46 The biggest limitation of the current study may be that OCD is underrepresented in the Swedish national patient register compared with the other disorders under study. This is largely due to the fact that OCD rarely requires hospitalization (outpatients were only included in the register from 2001) and that many sufferers do not seek help.…”

Section: Discussionmentioning

confidence: 89%

Obsessive-Compulsive Disorder, Psychosis, and Bipolarity: A Longitudinal Cohort and Multigenerational Family Study

Cederlöf

Lichtenstein

Larsson

et al. 2014

SCHBUL

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Obsessive-compulsive disorder (OCD) often co-occurs with psychotic and bipolar disorders; this comorbidity complicates the clinical management of these conditions. In this population-based longitudinal and multigenerational family study, we examined the patterns of comorbidity, longitudinal risks, and shared familial risks between these disorders. Participants were individuals with a diagnosis of OCD (n = 19 814), schizophrenia (n = 58 336), bipolar disorder (n = 48 180), and schizoaffective disorder (n = 14 904) included in the Swedish Patient Register between January 1969 and December 2009; their first-, second-, and third-degree relatives; and population-matched (1:10 ratio) unaffected comparison individuals and their relatives. The Swedish Prescribed Drug Register was used to control for the potential effect of medication in the longitudinal analyses. Individuals with OCD had a 12-fold increased risk of having a comorbid diagnosis of schizophrenia and a 13-fold increased risk of bipolar disorder and schizoaffective disorder. Longitudinal analyses showed that individuals first diagnosed with OCD had an increased risk for later diagnosis of all other disorders, and vice versa. The risk of bipolar disorder was reduced, but not eliminated, when the use of selective serotonin reuptake inhibitors was adjusted for. OCD-unaffected first-, second-, and third-degree relatives of probands with OCD had a significantly increased risk for all 3 disorders; the magnitude of this risk decreased as the genetic distance increased. We conclude that OCD is etiologically related to both schizophrenia spectrum and bipolar disorders. The results have implications for current gene-searching efforts and for clinical practice.

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“…It is possible that symptom types with greater genetic contribution are relatively treatment-resistant [45]. The distinction between Bjust right^and fear-based symptoms should be considered.…”

Section: Symptom Typementioning

confidence: 99%

Personalizing the Treatment of Pediatric Obsessive-Compulsive Disorder: Evidence for Predictors and Moderators of Treatment Outcomes

Caporino

Storch

2016

Curr Behav Neurosci Rep

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Cognitive behavioral therapy (CBT), delivered alone or with a serotonin reuptake inhibitor (SRI), is efficacious for treating pediatric obsessive-compulsive disorder (OCD), but not all youth respond optimally. Research to understand for whom a given intervention is beneficial can inform efforts to personalize treatment or tailor it to specific youths to enhance outcomes. We review studies that examined potential predictors/moderators of response to CBT, medication, and multimodal treatment for pediatric OCD: demographics, disorder-specific characteristics, general illness characteristics, neuropsychological functioning, biomarkers, family factors, and non-specific therapy factors. Methodological differences across studies make it challenging to synthesize findings and more research with large samples is needed. However, family factors have emerged as relatively consistent and strong predictors of treatment outcomes and there is preliminary support for attention to the presence of tics in treatment selection. There is little evidence for age and other demographic differences in treatment response.

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A Multivariate Twin Study of Obsessive-Compulsive Symptom Dimensions

Cited by 114 publications

References 41 publications

Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder

Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder

Obsessive-Compulsive Disorder, Psychosis, and Bipolarity: A Longitudinal Cohort and Multigenerational Family Study

Personalizing the Treatment of Pediatric Obsessive-Compulsive Disorder: Evidence for Predictors and Moderators of Treatment Outcomes

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