A multivariate primary tumour control analysis in 465 patients treated by radical radiotherapy for cancer of the tonsillar region: Clinical and treatment parameters as prognostic factors

Impact of the Position of a Gap on the Response of the R1H-Tumor of the Rat on Fractionated Split-Course Radiotherapy

“…This analysis showed that there was no significant influence of the length of the gap on the outcome of therapy. This finding is in contrast to results published by Maciejewski et al [13], Bataini et al [2], Lindstrom & Fowler [12] and Pajak et al [17]. There are some more subjects weakening Skladowski's statement: irradiation schedules have been changed for several times, varying dosages, as well as overall treatment times, lengths of the gap and doses per fraction.…”

Concomitant Boost Radiotherapy in Oropharynx Carcinomas

“…Radiotherapy alone provides acceptable local control for most T1 -3, N0-1 oropharyngeal carcinomas (1,(12)(13)(14)(15). Reflecting the paramount importance of tumor volume, however, local control is a decreasing function of stage, and the prognosis of patients with locally advanced disease treated by monofractionated RT is generally unfavorable (2,14,16).…”

“…Reflecting the paramount importance of tumor volume, however, local control is a decreasing function of stage, and the prognosis of patients with locally advanced disease treated by monofractionated RT is generally unfavorable (2,14,16). In the hope of improving these results, clinical research has centered on the modification of RT fractionation schedules and the addition of chemotherapy to RT.…”

“…In the hope of improving these results, clinical research has centered on the modification of RT fractionation schedules and the addition of chemotherapy to RT. In oropharynx cancers, a 10-day reduction in overall treatment time to around 5 weeks is estimated to yield a 10 -15% improvement in local control (14). Among the various schedules of unconventional fractionation, the accelerated concomitant boost has gained use in many centers because of convenience (3,17) and radiobiological rationale.…”

Avoidance of treatment interruption: an unrecognized benefit of accelerated radiotherapy in oropharyngeal carcinomas?

“…Based on evidence suggesting that increasing overall treatment time (OTT) is detrimental to locoregional control, accelerated RT programs have been intensively investigated during the past two decades. However, most clinical data regarding the importance of OTT came from series using conventionally fractionated RT, where treatment interruptions constituted the main cause of prolonged OTT (3,4). Besides considerably shortening OTT, accelerated schedules may also be associated with the potential advantage of minimizing treatment interruptions (1,5).…”