A multivariate modeling for analysis of factors controlling the particle size and viscosity in palm kernel oil esters-based nanoemulsions

Rezaee, Malahat; Basri, Mahiran; Rahman, Raja Noor Zaliha Raja Abdul; Salleh, Abu Bakar; Chaibakhsh, Naz; Masoumi, Hamid Reza Fard

doi:10.1016/j.indcrop.2013.10.046

Cited by 16 publications

(13 citation statements)

References 35 publications

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“…Emulsions are formed by the dispersion of one liquid, usually oil phase, into a second immiscible liquid, water or aqueous phase [12]. Emulsions are typically distinguished by their particle size and stabilization into three main categories namely macro-, nano-and microemulsions [13].…”

Section: Nanoemulsionsmentioning

confidence: 99%

“…High-energy methods have the ability to produce submicron emulsions from a large variety of materials, displaying homogenous flow and narrow droplet size distribution and thus have the potential to be utilized on an industrial scale [12,29]. However, there are a number of limitations to this method.…”

Section: <Table 2>mentioning

confidence: 99%

“…Nanoemulsions have attracted much interest in recent years over a number of different fields including the personal care, cosmetics, agrochemical, chemical, food and pharmaceutical industries [12,15]. Within the pharmaceutical industry, nanoemulsions are being investigated as a formulation approach suitable for a number of different administration routes such as topical, transdermal, parenteral, ocular, pulmonary, nasal and oral [26,28,41].…”

Section: <Table 2>mentioning

confidence: 99%

“…Moreover, nanoemulsions properties are formulation-dependent, meaning that a formulation that provides some desired characteristics is not always suitable for obtaining other favourable properties [12]. For example, the influence of co-solvent concentration on the initial mean droplet diameter, polydispersity index, turbidity and storage stability of nanoemulsions formed using spontaneous emulsification was investigated by Saberi and coworkers.…”

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confidence: 99%

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Opportunities and Challenges for the Nasal Administration of Nanoemulsions

Comfort¹,

Garrastazu²,

Pozzoli³

et al. 2015

CTMC

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18Nasal delivery has become a growing area of interest for drug administration as a consequence of several 19 practical advantages, such as ease of administration and non-invasiveness. Moreover, the avoidance of hepatic 20 first-pass metabolism and rapid and efficient absorption across the permeable nasal mucosa offer a promising 21 alternative to other traditional administration routes, such as oral or parenteral delivery. In fact, nasal delivery 22 has been proposed for a number of applications, including local, systemic, direct nose-to-brain and mucosal 23 vaccine delivery. Nanoemulsions, due to their stability, small droplet size and optimal solubilization properties,

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Section: Nanoemulsionsmentioning

confidence: 99%

Section: <Table 2>mentioning

confidence: 99%

Section: <Table 2>mentioning

confidence: 99%

mentioning

confidence: 99%

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Opportunities and Challenges for the Nasal Administration of Nanoemulsions

Comfort¹,

Garrastazu²,

Pozzoli³

et al. 2015

CTMC

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“…54 The width of the particle-size distribution was not strongly influenced by mixing rate, as described by Saberi et al 55 Similar results were observed for emulsion-droplet size and mixing rate for emulsification of nanoemulsions. 53,56 Previous studies 55,57 suggested that gentle mixing was needed to form very fine droplets, highlighting the importance of controlling this parameter. Mixing had to be more vigorous to obtain phase transitions.…”

mentioning

confidence: 99%

Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB

Su¹,

Yang²,

Wang³

et al. 2017

IJN

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This research aimed to develop and optimize a nanoemulsion-based formulation containing ceramide IIIB using phase-inversion composition for transdermal delivery. The effects of ethanol, propylene glycol (PG), and glycerol in octyldodecanol and Tween 80 systems on the size of the nanoemulsion region in the phase diagrams were investigated using water titration. Subsequently, ceramide IIIB loading was kept constant (0.05 wt%), and the proposed formulation and conditions were optimized via preliminary screening and experimental design. Factors such as octyldodecanol/(Tween 80:glycerol) weight ratio, water content, temperature, addition rate, and mixing rate were investigated in the preliminary screening experiment. Response surface methodology was employed to study the effect of water content (30%–70%, w/w), mixing rate (400–720 rpm), temperature (20°C–60°C), and addition rate (0.3–1.8 mL/min) on droplet size and polydispersity index. The mathematical model showed that the optimum formulation and conditions for preparation of ceramide IIIB nanoemulsion with desirable criteria were a temperature of 41.49°C, addition rate of 1.74 mL/min, water content of 55.08 wt%, and mixing rate of 720 rpm. Under optimum formulation conditions, the corresponding predicted response values for droplet size and polydispersity index were 15.51 nm and 0.12, respectively, which showed excellent agreement with the actual values (15.8 nm and 0.108, respectively), with no significant ( P >0.05) differences.

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Use of microalgae: Tetraselmis tetrathele extract in formulation of nanoemulsions for cosmeceutical application

et al. 2018

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Cosmeceuticals are cosmetic-hybrids intended to enhance health and beauty of the skin. Topical delivery of antioxidants from natural bioresources has gained attention in line with the increasing demand for harmless cosmetics. Tetraselmis tetrathele is a microalgae species, which has high antioxidant contents. In this work, ternary phase analysis with different compositions of oil, surfactant, and water was conducted to evaluate homogeneity and stability of nanoemulsion lotion containing 1% T. tetrathele extract. The three formulations T1, T2, and T3 containing various percentages of the surfactant Tween 80, T1 (20 wt% of Tween 80), T2 (15 wt% of Tween 80), and T3 (10 wt% of Tween 80), were analyzed for size and zeta potential to evaluate stability of the nanoemulsion. All particles were nanosized ranging from 102.3 to 249.5 nm. Zeta potential analysis for all emulsions showed negative values from − 33.2 to − 71.7 mV, which indicates high stability of the nanoemulsion. In order to evaluate the storage stability, a stability test was conducted at different temperature levels (4, 25, and 45 °C) for 10 weeks. At all temperature conditions, T1, T2, and T3 were stable with exception of T3 that precipitated and sedimented after 8 weeks. This study illustrated that T. tetrathele extract can be used as bioactive compound for nanocosmeceutical products, which has high homogeneity and stability.

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A multivariate modeling for analysis of factors controlling the particle size and viscosity in palm kernel oil esters-based nanoemulsions

Cited by 16 publications

References 35 publications

Opportunities and Challenges for the Nasal Administration of Nanoemulsions

Opportunities and Challenges for the Nasal Administration of Nanoemulsions

Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB

Use of microalgae: Tetraselmis tetrathele extract in formulation of nanoemulsions for cosmeceutical application

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