2009
DOI: 10.1038/tpj.2009.60
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A multistep validation process of biomarkers for preclinical drug development

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Cited by 26 publications
(40 citation statements)
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“…We have previously demonstrated that all of these genes are differentially expressed in the retina after 3 months of uncontrolled diabetes in multiple independent cohorts of animals and that the dysregulation occurs after different periods of hyperglycemia and loss of insulin signaling. In timecourse experiments examining 2 weeks, 1 month, and 3 months of uncontrolled diabetes, we demonstrated that changes in expression occur as early as two weeks (C1inh, C1s, Carhsp1, Chi3L1, End2, Gbp2, Hspb1, Jak3, Kcne2, Lama5, Lgals3, Lgals3bp, Nppa, Pedf, Timp) or at some time after 1 month and before 3 months (Ccr5, Dcamkl1, Ednrb, Icam1, Mct1, Pcgf1, Slc6a11, Stat3, Tnfrsf12a) (Freeman et al, 2010). In agreement with previous findings, all biomarker transcripts were differentially expressed (ANOVA, BH-MTC) with the exceptions of Ednrb, Lama5, Pcgf1, and Pedf which did not reach significance and pass multiple testing correction (Supplemental Table 1, Figure 4a).…”
Section: Resultsmentioning
confidence: 79%
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“…We have previously demonstrated that all of these genes are differentially expressed in the retina after 3 months of uncontrolled diabetes in multiple independent cohorts of animals and that the dysregulation occurs after different periods of hyperglycemia and loss of insulin signaling. In timecourse experiments examining 2 weeks, 1 month, and 3 months of uncontrolled diabetes, we demonstrated that changes in expression occur as early as two weeks (C1inh, C1s, Carhsp1, Chi3L1, End2, Gbp2, Hspb1, Jak3, Kcne2, Lama5, Lgals3, Lgals3bp, Nppa, Pedf, Timp) or at some time after 1 month and before 3 months (Ccr5, Dcamkl1, Ednrb, Icam1, Mct1, Pcgf1, Slc6a11, Stat3, Tnfrsf12a) (Freeman et al, 2010). In agreement with previous findings, all biomarker transcripts were differentially expressed (ANOVA, BH-MTC) with the exceptions of Ednrb, Lama5, Pcgf1, and Pedf which did not reach significance and pass multiple testing correction (Supplemental Table 1, Figure 4a).…”
Section: Resultsmentioning
confidence: 79%
“…We have previously reported a set of diabetes-associated retinal gene expression biomarkers for use in monitoring interventions seeking to reverse the diabetic phenotype in rat models of diabetes (Freeman et al, 2010). This 24 gene set encompasses genes related to inflammation, vascular function, and neuronal signaling (Table 2).…”
Section: Resultsmentioning
confidence: 99%
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“…Coordinated phosphorylation and dephosphorylation of CARHSP1 contribute to the multiple phosphorylated isoforms of CARHSP1 in acinar cells (9). Recently, CARHSP1 was discovered as a biomarker for diabetic retinopathy (10) and as a regulator of TNF-␣ mRNA stability in macrophages (11). CARHSP1 may be involved in oxidative stress via traffic between stress granules and processing bodies (12).…”
mentioning
confidence: 99%