A multisociety Delphi consensus statement on new fatty liver disease nomenclature

Rinella, Mary E.; Lazarus, Jeffrey V.; Ratziu, Vlad; Francque, Sven; Sanyal, Arun J.; Kanwal, Fasiha; Romero, Diana Fernández; Abdelmalek, Manal F.; Anstee, Quentin M.; Arab, Juan Pablo; Arrese, Marco; Bataller, Ramón; Beuers, Ulrich; Boursier, Jérôme; Bugianesi, Elisabetta; Byrne, Christopher D.; Narro, Graciela Elia Castro; Chowdhury, Abhijit; Cortez‐Pinto, Helena; Cryer, Donna; Cusi, Kenneth; Kassas, Mohamed El; Klein, Samuel; Eskridge, Wayne; Fan, Jian‐Gao; Gawrieh, Samer; Guy, Cynthia D.; Harrison, Stephen A.; Kim, Seung Up; Koot, Bart; Korenjak, Marko; Kowdley, Kris V.; Lacaille, Florence; Loomba, Rohit; Mitchell-Thain, Robert; Morgan, Timothy R.; Powell, Elisabeth; Roden, Michael; Romero–Gómez, Manuel; Silva, Marcelo; Singh, Shivaram Prasad; Sookoian, Silvia; Spearman, C Wendy; Tiniakos, Dina; Valenti, L.; Vos, Miriam B.; Wong, Vincent Wai‐Sun; Xanthakos, Stavra A.; Yılmaz, Yusuf; Younossi, Zobair M.; Hobbs, A; Villota-Rivas, Marcela; Newsome, Philip; Ajmeral, Veeral; Alazawi, William; Alkhatry, Maryam; Loomba, Rohit; Allen, Alina M.; Allison, Michael; Alswat, Khalid; Álvares‐da‐Silva, Mário Reis; Auger, Michèle; Armstrong, Matthew J.; Arufe, Diego; Aschner, Pablo; Baffy, György; Bansal, Meena B.; Bédossa, Pierre; Belfort, Renata; Berg, Thomas; Anstee, Quentin M.; Betel, Michael; Bianco, Cristiana; Brass, Clifford A.; Brosgart, Carol; Brunt, Elizabeth M.; Buti, Marı́a; Caldwell, Steve; Carr, Rotonya M.; Casanovas, Teresa; Castéra, Laurent; Caussy, Cyrielle; Cerda, Eira; Chalasani, Naga; Chan, Wah Kheong; Charatcharoenwitthaya, Phunchai; Charlton, Michael; Cheung, Amanda; Chiodi, Daniela; Chung, Raymond T.; Cohen, David E.; Corey, Kathleen E.; Cotrim, Helma Pinchemel; Crespo, Javier; Dassanayake, Anuradha S; Davidson, Nicholas O.; Knegt, Robert J. de; Lédinghen, Victor de; Demir, Münevver; Díaz, Sebastián; Diehl, Anna Mae; Dimmig, Bruce; Dirchwolf, Melisa; Duseja, Ajay; Dvořák, Karel; Ekstedt, Mattias; Wakil, Reda El; Ferraz, Maria Lúcia Gomes; Friedman, Scott L.; Fuchs, Michael; Gastaldelli, Amalia; Geerts, Anja; Geier, Andreas; Girala, Marcos; Goh, George Boon‐Bee; Goossens, Nicolas; Graupera, Isabel; Hagström, Hannes; Henry, Zachary; Hunyady, Béla; Hutchison, Alan L.; Isaacs, Scott; Jornayvaz, François R.; Kemp, Christopher G.; Kile, Denise; Kim, Won; Kleiner, David E.; Kohli, Rohit; Kugelmas, Marcelo; Lavine, Joel E.; Lazo, Mariana; Leite, Nathalie C.; Lozano, Adelina; Luukkonen, Panu K.; Macedo, M. Paula; Mansour, Dina; Mantzoros, Christos S.; Marchesini, Giulio; Marciano, Sebastián; Martínez, Kim; Mateva, Л.; Mato, José M.; McCary, Alexis; Miele, Luca; Mikolašević, Ivana; Miller, Veronica; Moreno, R.; Moylan, Cynthia A.; Nakajima, Akira; Nault, Jean–Charles; Norris, Suzanne; Noureddin, Mazen; Oliveira, Cláudia Pinto Marques Souza de; Ong, A. S. H.; Padilla, Martín; Pais, Raluca; Panduro, Arturo; Panigrahi, Manas; Papatheodoridis, George; Pelusi, Serena; Pérez, Marlene; Escobar, John Willmer; Perseghin, Gianluca; Pessôa, Mário; Petta, Salvatore; Pinzani, Massimo; Lupşor, M.; Rabiee, Atoosa; Romeo, Stefano; Rotman, Yaron; Rowe, Ian A; Salupere, Riina; Satapathy, Sanjaya K.; Schattenberg, Jörn M.; Schaufert, Wendy; Schnabl, Bernd; Seim, Lynn; Serfaty, Lawrence; Shapiro, D. A.; Singal, Ashwani K.; Skladaný, Ľubomír; Stefan, Norbert; Stine, Jonathan G.; Sundaram, Shikha S.; Svegliati‐Baroni, Gianluca; Szabó, Gyöngyi; Tacke, Frank; Tanwandee, Tawesak; Targher, Giovanni; Terrault, Norah A.; Neuschwander‐Tetri, Brent A.; Thiele, Maja; Tisthammer, B.; Delgadillo, Aldo Torre; Trauner, Michael; Tsochatzis, Emmanuel; Kleef, Laurens A. van; Mil, Saskia Van; VanWagner, Lisa B.; Velasco, José Antonio Velarde Ruiz; Vesterhus, Mette; Vilar-Gómez, Eduardo; Watt, Kymberly D.; Wattacheril, Julia; Wilkins, Fonda; Willemse, J.; Zekry, Amany; Zelber‐Sagi, Shira

doi:10.1016/j.jhep.2023.06.003

Cited by 434 publications

(182 citation statements)

References 32 publications

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“…Because the data are deidentified and publicly accessible, no additional review board approval was required (eMethods in Supplement 1). SLD was defined as ultrasonography-confirmed hepatic steatosis . An intermediate or high risk for advanced fibrosis was defined by a Fibrosis-4 index (FIB-4) score of 1.3 or higher.…”

Section: Methodssupporting

confidence: 88%

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Alcohol Intake Thresholds Among Individuals With Steatotic Liver Disease

Yeo,

Zhu,

Arab

et al. 2023

JAMA Netw Open

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Section: Methodssupporting

confidence: 88%

“…Alcohol exacerbates liver disease progression, leading to advanced fibrosis and cirrhosis. A recent update in nomenclature, steatotic liver disease (SLD), encompasses all fatty liver diseases confirmed by histological or radiological evidence, irrespective of etiology …”

Section: Introductionmentioning

confidence: 99%

Alcohol Intake Thresholds Among Individuals With Steatotic Liver Disease

Yeo,

Zhu,

Arab

et al. 2023

JAMA Netw Open

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“…Several large international liver disease societies recommended changing the nosology of fatty liver disease to steatotic liver disease (SLD), with subcategories of metabolic dysfunction–associated steatotic liver disease (MASLD), alcohol liver disease (ALD), and the combination of MASLD and ALD as “MetALD.” The impact of this shift will need to be evaluated in subsequent studies and reflected in updated guidelines. Upcoming data from larger RCTs of GLP1RAs, GIPRAs/GLP1RAs, and sodium-glucose cotransporter 2 inhibitors should help clarify their direct effects on NASH.…”

Section: Areas In Need Of Future Study or Ongoing Researchmentioning

confidence: 99%

Diagnosis and Management of Nonalcoholic Fatty Liver Disease

Leung,

Davis,

Kumar

2023

JAMA

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“…The renaming comes after a two year process led by the American Association for Study of Liver Disease and EASL in collaboration with the Asociación Latinoamericana para el Estudio del Hígado. Details of the renaming will be published in the Journal of Hepatology 1…”

mentioning

confidence: 99%

“…British experts and authors for the Journal of Hepatology report come from Oxford, Southampton, Newcastle, and Birmingham 1…”

mentioning

confidence: 99%